A5090972752- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cyclopropane Reaction Mechanisms
- Pain Mechanisms and Treatments
- Synthetic Organic Chemistry Methods
- Cancer-related Molecular Pathways
- Catalytic Alkyne Reactions
- Neuroendocrine regulation and behavior
- Retinoids in leukemia and cellular processes
- Fluorine in Organic Chemistry
- Vagus Nerve Stimulation Research
- Enzyme Production and Characterization
- Catalytic C–H Functionalization Methods
- Chromosomal and Genetic Variations
- Acute Myeloid Leukemia Research
- Advanced biosensing and bioanalysis techniques
- Phytase and its Applications
- Crystallography and molecular interactions
- Herpesvirus Infections and Treatments
- Tryptophan and brain disorders
- Advanced Optical Sensing Technologies
- Heart Rate Variability and Autonomic Control
- Cancer Genomics and Diagnostics
- Healthcare and Venom Research
- Chaos control and synchronization
AfaSci (United States)
2021-2024
Harbin Institute of Technology
2024
State Forestry and Grassland Administration
2024
Yuzhang Normal University
2024
Huaibei Normal University
2024
Ruijin Hospital
2020-2023
Shanghai Jiao Tong University
2014-2023
Shanghai Institute of Hematology
2020-2023
Center for Cancer Research
2023
Massachusetts General Hospital
2023
Tumor suppressor p53 is inactivated by thousands of heterogeneous mutations in cancer, but their individual druggability remains largely elusive. Here, we evaluated 800 common mutants for rescue potencies the representative generic compound arsenic trioxide (ATO) terms transactivation activity, cell growth inhibition, and mouse tumor–suppressive activities. The were mainly determined solvent accessibility mutated residue, a key factor determining whether mutation structural one, temperature...
This review describes the literature of nucleophilic additions organometallic and metal hydride reagents to cyclopropenes with a particular focus on regiochemical stereochemical aspects addition reactions.
Abstract PPM1D encodes a phosphatase that is recurrently activated across cancer, most notably in therapy-related myeloid neoplasms. However, the function of hematopoiesis and its contribution to tumor cell growth remain incompletely understood. Using conditional mouse models, we uncover central role for Ppm1d validate potential as therapeutic target. We find regulates competitive fitness self-renewal hematopoietic stem cells (HSCs) with without exogenous genotoxic stresses. also show...
A diastereoselective procedure has been developed for the Cu-catalyzed addition of diorganozinc reagents to cyclopropene derivatives. Ester and oxazolidinone functions direct a variety organozinc with excellent facial selectivity. The resulting cyclopropylzinc can be captured via stereospecific reactions electrophiles. Cycloprop-2-ene carboxylic esters, which are directly available from transition-metal-catalyzed alkynes α-diazo utilized in carbozincation protocols. Both diastereoselectivity...
The tumor suppressor p53 is inactivated by over hundreds of heterogenous mutations in cancer. Here, we purposefully selected phenotypically reversible temperature-sensitive (TS) for pharmacological rescue with thermostability as the compound-screening readout. This rational screening identified antiparasitic drug potassium antimony tartrate (PAT) an agent that can thermostabilize representative TS mutant p53-V272M via noncovalent binding. PAT met three basic criteria a targeted drug:...
P2X receptors on dorsal root ganglion (DRG) neurons have been strongly implicated in pathological nociception after peripheral nerve injuries or inflammation. However, nothing is known of a role for purinergic neuropathic pain produced by chronic compression DRG (CCD) - an injury that may accompany intraforaminal stenosis, laterally herniated disc other disorders the spine leading to radicular pain. In rat model compression, hyperexcitable retain functioning axonal connections with their...
Described is a Cu-catalyzed methodology for adding aryl Grignard reagents to 3-hydroxymethylcyclopropene derivatives with high regio- and diastereoselectivity. The cyclopropylmetals can be trapped variety of electrophiles generate highly substituted cyclopropanes.
Forest ecological benefit compensation protects the environment, increases enthusiasm among forest builders, legitimate economic interests of landowners, and maintains environmental security. In this study, a systematic analysis was conducted on 4062 publications in field international identified using Web Science core collection Citation Index Expanded (SCI-E) Social (SSCI) databases alongside CiteSpace optical measurement software. The research status influence countries were tracked,...
Background Dayu County, a major tungsten producer in China, experiences severe heavy metal pollution. This study evaluated the pollution status, accumulation characteristics paddy rice, and potential ecological risks of metals agricutural soils near mining areas County. Furthermore, impacts soil properties on were explored. Methods The geo-accumulation index (I geo ), contamination factor (CF), load (PLI) used to evaluate status (As, Cd, Cu, Cr, Pb, Mo, W, Zn) soils. risk (RI) was assess...
Pain contains both sensory and affective dimensions. Using a rodent visceral pain assay that combines the colorectal distension (CRD) model with conditioned place avoidance (CPA) paradigms, we measured learned behavior directly reflects component of pain, showed perigenual anterior cingulate cortex (pACC) activation is critical for memory processing involved in long-term state prediction aversive stimuli by contextual cue. Progress has been made suggested vagal afferents plays role...
The intranasal administration of oxytocin (OT) reduces migraine headaches through activation the receptor (OTR). Magnesium ion (Mg2+) concentration is critical to OTR, and a low serum Mg2+ predictive headache. We, therefore, examined functional impact on OT-OTR binding efficacy using two complimentary bioassays.Current clamp recordings rat trigeminal ganglia (TG) neurons measured an OT-induced reduction in excitability. In addition, we assessed craniofacial analgesia rats.While OT alone...
[reaction: see text] In this Letter, we describe a general method for preparing the dianions of cyclopropene carboxylic acids, and show that their subsequent reactions with electrophiles provide means selectively introducing diverse types functional groups. This provides synthesis chiral 1,2-disubstituted cyclopropenes, opens new avenues enantioselective preparation cyclopropenes.
Large-scale syntheses of 3-(cycloprop-2-en-1-oyl)oxazolidinones from acetylene and ethyl diazoacetate are described. Unlike other cyclopropenes that bear a single substitutent at C-3, these compounds stable to long-term storage. Although the cyclopropene derivatives unusually stable, they reactive toward cyclic acyclic dienes in stereoselective Diels−Alder reactions.
Arsenic trioxide (ATO) targets PML/RARα and leads to miraculous success in treating acute promyelocytic leukemia. Notably, ATO also p53, the most frequently mutated protein cancers, through a similar binding mechanism. However, p53-targeting trials are challenging due poor cellular uptake cancer selectivity of ATO. Here, we analyzed structure–activity relationship arsenicals rationally developed novel arsenical (designated AcGlcAs) by conjugating arsenic sulfur atoms...