A5031115987- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Cerebrospinal fluid and hydrocephalus
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Spinal Cord Injury Research
- Spinal Dysraphism and Malformations
- Traumatic Brain Injury and Neurovascular Disturbances
- Psoriasis: Treatment and Pathogenesis
- Stress Responses and Cortisol
- Mosquito-borne diseases and control
- Asthma and respiratory diseases
- Dementia and Cognitive Impairment Research
- interferon and immune responses
- Italy: Economic History and Contemporary Issues
- Migration and Labor Dynamics
- Migration, Ethnicity, and Economy
- Bacterial Infections and Vaccines
- Neurological disorders and treatments
- Vascular Malformations Diagnosis and Treatment
- Poverty, Education, and Child Welfare
Washington University in St. Louis
2021-2024
University of Virginia
2018-2023
Abstract The adaptive immune system relies on formation of the memory past microbial challenges to accelerate protective responses in event reinfection. This is accomplished part by retention antigen-specific B and T cells within barrier tissues. As healthy central nervous parenchyma virtually devoid cells, meningeal spaces carry out vital function coping with environmental threats during aging. We conducted an extensive molecular functional analysis test hypothesis that meninges brain sense...
Summary Mechanisms governing how immune cells and their derived molecules impact homeostatic brain function are still poorly understood. Here, we elucidate neuronal mechanisms underlying effects of T on synaptic episodic memory. Depletion CD4 led to memory deficits impaired long term potentiation. Severe combined immune-deficient (SCID) mice exhibited amnesia, which was reversible by repopulation with from wild-type but not IL-4-knockout mice. This rescue mediated via IL-4 receptors (IL-4R)...