A5008864337- Neuroinflammation and Neurodegeneration Mechanisms
- Neurobiology and Insect Physiology Research
- Olfactory and Sensory Function Studies
- Wikis in Education and Collaboration
- Gut microbiota and health
- Diversity and Career in Medicine
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Social Media in Health Education
- Alzheimer's disease research and treatments
- Biochemical Analysis and Sensing Techniques
- Immune Response and Inflammation
- Neural dynamics and brain function
- Health and Medical Research Impacts
- CRISPR and Genetic Engineering
- Transcranial Magnetic Stimulation Studies
- Childhood Cancer Survivors' Quality of Life
- Pluripotent Stem Cells Research
- Genetic Syndromes and Imprinting
- Misinformation and Its Impacts
- RNA Research and Splicing
- Gastrointestinal motility and disorders
- Nicotinic Acetylcholine Receptors Study
- Hate Speech and Cyberbullying Detection
- Web and Library Services
Salk Institute for Biological Studies
2020-2025
Institute for Biological Sciences
2025
Washington University in St. Louis
2020-2024
Massachusetts Institute of Technology
2022
Occupational Cancer Research Centre
2019-2020
University of Toronto
2019-2020
Tau-mediated neurodegeneration is a hallmark of Alzheimer's disease. Primary tauopathies are characterized by pathological tau accumulation and neuronal synaptic loss. Apolipoprotein E (ApoE)-mediated neuroinflammation involved in the progression tau-mediated neurodegeneration, emerging evidence suggests that gut microbiota regulates an APOE genotype-dependent manner. However, causal link between lacking. In this study, we genetically engineered mouse model tauopathy expressing human ApoE...
Affiliative social connections facilitate well-being and survival in numerous species. Engaging interactions requires positive or negative motivational drive, elicited through coordinated activity across neural circuits. However, the identity, interconnectivity, functional encoding of information within these circuits remains poorly understood. Here, we focus on downstream projections dorsal raphe nucleus (DRN) dopamine neurons (DRN DAT ), which previously implicated motivation alongside an...
Animals exhibit innate behaviors that are stereotyped responses to specific evolutionarily relevant stimuli in the absence of prior learning or experience. These can be reduced an axis valence, whereby odors evoke approach avoidance responses. The posterolateral cortical amygdala (plCoA) mediates attraction and aversion odor. However, little is known about how this brain area gives rise opposing motivational valence. Here, we sought define circuit features plCoA give We characterized...
Animals exhibit innate behaviors that are stereotyped responses to specific evolutionarily relevant stimuli in the absence of prior learning or experience. These can be reduced an axis valence, whereby odors evoke approach avoidance responses. The posterolateral cortical amygdala (plCoA) mediates attraction and aversion odor. However, little is known about how this brain area gives rise opposing motivational valence. Here, we sought define circuit features plCoA give We characterized...
Abstract Protein interactions of Tau are interest in efforts to decipher pathogenesis Alzheimer’s disease, a subset frontotemporal dementias, and other tauopathies. We CRISPR-Cas9 edited two human cell lines generate broadly adaptable models for neurodegeneration research. applied the system inducibly express balanced levels 3-repeat 4-repeat wild-type or P301L mutant Tau. Following 12-h induction, quantitative mass spectrometry revealed Parkinson’s disease-causing protein DJ-1 non-muscle...
While research has explored the extent of gender bias and barriers to women's inclusion on English-language Wikipedia, very little focused problem racial within encyclopedia. Despite advocacy groups' efforts incrementally improve representation much is unknown regarding how biographies are assessed after creation. Applying a combination web-scraping, deep learning, natural language processing, qualitative analysis pages academics nominated for deletion we demonstrate Wikipedia's notability...
There exists a dearth of supplementary programs to educate physician-scientist trainees on anti-racism and topics surrounding social justice in medicine science. Education these is critical prevent the perpetuation systemic racism within institutions academia medicine. Students Washington University School Medicine Medical Scientist Training Program Tri-Institutional MD-PhD developed journal clubs with curricula focused for summer 2020. In this article, we describe impact club education...
SUMMARY In order to respond appropriately threats in the environment, brain must rapidly determine whether a stimulus is important and it positive or negative, then use that information direct behavioral responses. Neurons amygdala have long been implicated valence encoding fear responses threatening stimuli, but show transient firing response these stimuli do not match timescales of associated For decades, there has logical gap how could be mediated without an ensemble representation...
Recent guidance from the US Immigration and Customs Enforcement drastically altered lives of international students in America, especially those who are matriculating. This commentary describes how still face uncertainty concerning their visa statuses place American society.
Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare, non-neoplastic, slow-growing tumors that can present anywhere throughout central nervous system. While etiology these lesions remains unknown, mainstay treatment is surgical excision. We describe a case CAPNON at our institution in 66 year-old female patient who presented with 5 months pain and burning sensation her thigh. On MRI, an intradural extramedullary lesion was identified level T11-T12. The mass surgically excised...
Environmental enteric dysfunction (EED), a small intestinal disorder found at high prevalence in stunted children, is associated with gut mucosal barrier disruption and decreased absorptive capacity due to reduced intact villi. To test the hypothesis that intergenerational transmission of perturbed microbiota contributes undernutrition by inducing EED, we characterized two consortia bacterial strains cultured from duodenal aspirates Bangladeshi children one which induced local systemic...
Abstract Animals exhibit innate behaviors that are stereotyped responses to specific evolutionarily relevant stimuli in the absence of prior learning or experience. These can be reduced an axis valence, whereby odors evoke approach avoidance responses. The posterolateral cortical amygdala (plCoA) mediates attraction and aversion odor. However, little is known about how this brain area gives rise opposing motivational valence. Here, we sought define circuit features plCoA give We...
<sec> <title>BACKGROUND</title> After the Supreme Court overturned Roe v Wade, confusion followed regarding legality of abortion in different states across country. Recent studies found increased Google searches for abortion-related terms restricted after Dobbs decision was leaked. Since patients and providers use Wikipedia as a predominant medical information source, we hypothesized that changes reproductive health information-seeking behavior could be better understood by examining article...
After the US Supreme Court overturned Roe v. Wade, confusion followed regarding legality of abortion in different states across country. Recent studies found increased Google searches for abortion-related terms restricted after Dobbsv. Jackson Women's Health Organization decision was leaked. As patients and providers use Wikipedia (Wikimedia Foundation) as a predominant medical information source, we hypothesized that changes reproductive health information-seeking behavior could be better...
Complete hydatidiform mole with coexisting fetus (CHMCF) is rare, and diagnosis challenging due to limited data. Here, we present the case of a patient noninvasive prenatal test (NIPT) resulting in "likely molar pregnancy" second trimester. Subsequent ultrasound confirmed cystic appearing portion placenta. At 22 weeks, delivered demised two placentas. Pathology was consistent CHMCF. This first show primary detection CHMCF single-nucleotide polymorphism (SNP)-based NIPT prior identification....
<title>Abstract</title> Affiliative social connections facilitate well-being and survival in numerous species. Engaging interactions requires positive negative motivational drive, elicited through coordinated activity across neural circuits. However, the identity, interconnectivity, functional encoding of information within these circuits remains poorly understood. Here, we focused on downstream projections dorsal raphe nucleus (DRN) dopamine neurons (DRN<sup>DAT</sup>), which previously...
Here, we present the amygdalostriatal transition zone (ASt) as a missing piece of highly conserved process paramount importance for survival, which represents an internal state (e.g. fear) that can be expressed in multiple motor outputs freezing or escape). From vivo cellular resolution recordings include both electrophysiology and calcium imaging, find ASt neurons are sparse coding, extremely high signal-to-noise, maintain sustained response negative valence stimuli duration defensive...
CRISPR-Cas9 technology has transformed the ability to edit genomic sequences and control gene expression with unprecedented ease scale. However, precise insertions of coding using this remain time-consuming inefficient because they require introducing adjacent single-strand cuts through Cas9 nickase action invoking host-encoded homology-directed repair program concomitant introduction large templates. Here, we present a system for rapid study any protein-of-interest in two neuronal cell...
Abstract Background Although mounting evidence supports that an unbalanced gut microbiota (GM) is linked to amyloid‐β deposition, the contribution of GM tau‐mediated neurodegeneration (TN) poorly characterized. Our preliminary data have shown manipulations, using either treatment with a combination antibiotics (ABX) or raising animals in germ‐free (GF) conditions, regulate TN (Seo, et al., AAIC 2021). However, further investigation needed sort out underlying mechanisms are involved...