A5029645768- Neuroscience and Neuropharmacology Research
- Asymmetric Hydrogenation and Catalysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- NF-κB Signaling Pathways
- Catalytic Cross-Coupling Reactions
- Carbon dioxide utilization in catalysis
- Neural dynamics and brain function
- Anesthesia and Neurotoxicity Research
- Chemical Synthesis and Analysis
- Crystallography and molecular interactions
- Ionic liquids properties and applications
- Advanced Synthetic Organic Chemistry
- Neuroendocrine regulation and behavior
- Genetics and Neurodevelopmental Disorders
- Bacteriophages and microbial interactions
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Bacterial Genetics and Biotechnology
- Histone Deacetylase Inhibitors Research
- Surface Chemistry and Catalysis
- Organophosphorus compounds synthesis
- Enhanced Recovery After Surgery
University of Buenos Aires
2007-2023
Fundación Ciencias Exactas y Naturales
2011-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2007-2023
Instituto de Neurología de Buenos Aires
2023
Massachusetts Institute of Technology
2022
Universitat Rovira i Virgili
2010-2014
Institut Pasteur
1997
Expression Génétique Microbienne
1995
Abstract This Review deals with the asymmetric hydrogenation and transfer of imines some nitrogen‐containing heteroaromatic compounds to afford amines. Hydrogenation are covered in separate sections. Particular attention is devoted substrates, since this reaction highly substrate dependent. In way general structural trends imine presented, highlighting more challenging substrates. Since acyclic cyclic (including heteroaromatic) have different features they also presented separately. The...
In fear conditioning, aversive stimuli are readily associated with contextual features. A brief reexposure to the training context causes memory reconsolidation, whereas a prolonged induces extinction. The regulation of hippocampal gene expression plays key role in consolidation and reconsolidation. However, mechanisms that determine whether will reconsolidate or extinguish not known. Here, we demonstrate opposing roles for two evolutionarily related transcription factors mouse hippocampus....
Initially, memory is labile and requires consolidation to become stable. However, several studies support that consolidated memories can undergo a new period of lability after retrieval. The mechanistic differences this process, termed reconsolidation, with the process are under debate, including participation hippocampus. Up point, few reports describe molecular changes and, in particular, transcription factor (TF) involvement restabilization. Increasing evidence supports TF nuclear...
Novel cis-1,2-bis(di-tert-butyl-phosphinomethyl) carbocyclic ligands 6-9 have been prepared and the corresponding palladium complexes [Pd(O(3)SCH(3))(L-L)][O(3)SCH(3)] (L-L=diphosphine) 32-35 synthesised characterised by NMR spectroscopy X-ray diffraction. These diphosphine give very active catalysts for palladium-catalysed methoxycarbonylation of ethene. The activity varies with size backbone, 7 9, containing four- six-membered ring backbones giving more systems. acid used as co-catalyst...
Memory consolidation requires gene expression regulation by transcription factors, which eventually may induce chromatin modifications as histone acetylation. This mechanism is regulated acetylases and deacetylases. It not yet clear whether memory always recruits acetylation or it only engaged in more persistent memories. To address this question, we used different strength of training for novel object recognition task mice. Only strong induced a long-lasting an increase hippocampal H3...
The ubiquitin–proteasome system (UPS) of protein degradation has been evaluated in different forms neural plasticity and memory. role UPS such processes is controversial. Several results support the idea that activation this memory consolidation necessary to overcome negative constrains for plasticity. In case, inhibition during impairs Similar were reported reconsolidation. However, other cases, had no effect on reconsolidation but impedes amnesic action synthesis after retrieval. last...
The first phosphine-free Pd-catalysed double carbonylation of aryl iodides is reported as a general and practical method, giving excellent conversions selectivities for wide range amine nucleophiles under atmospheric CO pressure.
Protein phosphatases are important regulators of neural plasticity and memory. Some studies support that the Ca(2+) /calmodulin-dependent phosphatase calcineurin (CaN) is, on one hand, a negative regulator memory formation and, other positive extinction reversal learning. However, signaling mechanisms by which CaN exerts its action in such processes not well understood. Previous findings negatively regulate nuclear factor kappaB (NF-κB) pathway during extinction. Here, we have studied role...
Abstract The mechanism of the experimentally reported phosphine‐free palladium‐catalysed carbonylation aryl iodides with amines in presence 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) as base was investigated at DFT level. Paths were identified for both di‐ and monocarbonylation, calculated selectivity three different substrates agreement experiment. In dicarbonylation yielding α‐ketoamides, formation second carbon–carbon bond occurs through reductive elimination Pd acyl amide intermediate...
Abstract An efficient methodology for the synthesis of amides via palladium‐catalysed aminocarbonylation aryl iodides is reported using bulky cis ‐1,2‐bis[(di‐ tert ‐butylphosphino)methyl]cyclohexane ligand under atmospheric pressure carbon monoxide. Excellent conversions (up to 99%) and chemoselectivities were obtained a range amine nucleophiles. The effect substituents on substrate nucleophiles catalytic performance was investigated. NMR study also carried out key intermediates cycle...
Abstract Phosphinoimidazoline (PHIM) ligands bearing a triazolylmethyl substituent at the sp 3 nitrogen atom in imidazoline ring lead to highly improved enantioselectivity (up 99% ee ) allylic substitution reactions with respect analogous substituents lacking triazole unit. NMR and theoretical studies support shift coordination mode of PHIM ligand palladium, triggered by very favourable interaction
An efficient catalytic system to perform allylic alkylation in ionic liquids based on a Pd/phosphine imidazoline has been designed. This affords very good results (ee's up 95%) when used with the appropriate liquid as well under microwave conditions. Recycling experiments were conducted showing promising results.
As part of the international project to sequence Bacillus subtilis genome, DNA region located between gerBC (311°) and licR (334°) was assigned Institut Pasteur. In this paper, cloning sequencing 176 kb analysis entire 271 (6·5% B. chromosome) is described; 273 putative coding sequences were identified. Although complete genome seven other organisms (five bacteria, one archaeon yeast Saccharomyces cerevisiae ) are available in public databases, 65 genes from chromosome encode proteins...
Abstract Memories are a product of the concerted activity many brain areas. Deregulation consolidation and reprocessing mnemonic traces that encode fearful experiences might result in fear-related psychopathologies. Here, we assessed how pre-established memories change with experience, particularly labilization/reconsolidation memory, using whole-brain analysis technique positron emission tomography male mice. We found differences glucose consumption lateral neocortex, hippocampus amygdala...
An experimental setup capable of stimulating, inhibiting, sensing, processing and analyzing a biological system is presented. The based on open-source, open hardware commercial devices. It can be applied to record control neuronal activity, for example establish causal links between neurons behavior in closed-loop fashion. Cells or group cells triggered by acoustical, electrical light impulses. This last case technique defined as optogenetics. latter used an that reads controls activity...
Abstract Dendritic spines are plastic structures exhibiting a high degree of morphological variability. Certain morphometric parameters, such as volume, positively correlate with the strength synapse in which they participate. Memories, too, subject to change over time and experiences. In particular, presence reminder learning event can trigger labilization memory trace, followed by re-stabilization process termed reconsolidation. The underlying mechanisms behind labilization/reconsolidation...