A5089495047- Neurobiology and Insect Physiology Research
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Animal Behavior and Reproduction
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Circadian rhythm and melatonin
- Biochemical Analysis and Sensing Techniques
- bioluminescence and chemiluminescence research
- Functional Brain Connectivity Studies
- Fusion and Plasma Physics Studies
- Insect and Arachnid Ecology and Behavior
- Zebrafish Biomedical Research Applications
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Insect Utilization and Effects
- Neuroscience and Neural Engineering
- Advanced Fluorescence Microscopy Techniques
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Nuclear Receptors and Signaling
- Ion channel regulation and function
University of California, San Diego
2007-2024
Howard Hughes Medical Institute
2014
Columbia University
2014
Columbia University Irving Medical Center
2013
The internal state of an organism influences its perception attractive or aversive stimuli and thus promotes adaptive behaviors that increase likelihood survival. mechanisms underlying these perceptual shifts are critical to our understanding how neural circuits support animal cognition behavior. Starved flies exhibit enhanced sensitivity odors reduced odors. Here, we show a functional remodeling the olfactory map is mediated by two parallel neuromodulatory systems act in opposing directions...
The role of classical neurotransmitters in the transfer and processing olfactory information is well established many organisms. Neuropeptide action, however, largely unexplored any peripheral system. A subpopulation local interneurons (LNs) Drosophila antannal lobe peptidergic, expressing tachykinins (DTKs). We show here that receptor neurons (ORNs) express DTK (DTKR). Using two-photon microscopy, we found applied to antennal suppresses presynaptic calcium synaptic transmission ORNs....
Investigating how information propagates between layers in the olfactory system is an important step toward understanding code. Each glomerular output projection neuron (PN) receives two sources of input: receptor neurons (ORNs) same glomerulus and interneurons that innervate many glomeruli. We therefore asked these inputs interact to produce PN output. used gene mutations silence all ORNs innervating a specific recorded activity with two-photon calcium imaging electrophysiology. found...
Sensory systems must be able to extract features of environmental cues within the context different physiological states organism and often temper their activity in a state-dependent manner via process neuromodulation. We examined effects neuromodulator serotonin on well-characterized sensory circuit, antennal lobe Drosophila melanogaster, using two-photon microscopy genetically expressed calcium indicator, G-CaMP. Serotonin enhances sensitivity output projection neurons an odor-specific...
Neurotransmitter signaling in the mature nervous system is well understood, but functions of transmitters immature are less clear. Although released during embryogenesis regulate neuronal proliferation and migration, little known about their role regulating early differentiation. Here, we show that GABA glutamate drive calcium-dependent embryonic electrical activity regulates transmitter specification. The number neurons expressing different changes when or blocked chronically, either using...
Animals exhibit innate behaviors that are stereotyped responses to specific evolutionarily relevant stimuli in the absence of prior learning or experience. These can be reduced an axis valence, whereby odors evoke approach avoidance responses. The posterolateral cortical amygdala (plCoA) mediates attraction and aversion odor. However, little is known about how this brain area gives rise opposing motivational valence. Here, we sought define circuit features plCoA give We characterized...
Animals exhibit innate behaviors that are stereotyped responses to specific evolutionarily relevant stimuli in the absence of prior learning or experience. These can be reduced an axis valence, whereby odors evoke approach avoidance responses. The posterolateral cortical amygdala (plCoA) mediates attraction and aversion odor. However, little is known about how this brain area gives rise opposing motivational valence. Here, we sought define circuit features plCoA give We characterized...
The ways in which sensory stimuli acquire motivational valence through association with other is one of the simplest forms learning. Though we have identified many brain nuclei that play various roles reward processing, a significant gap remains understanding how value encoding transforms layers processing. To address this gap, carried out comparative investigation olfactory tubercle (OT), and ventral pallidum (VP) - 2 connected basal ganglia both been implicated First, using anterograde...
Abstract The intercalated cells of the amygdala (ITCs) are a fundamental processing structure in that remain relatively understudied. They phylogenetically conserved from insectivores through primates, inhibitory, and project to several main output stations basal forebrain. Through these connections, ITCs best known for their role conditioned fear, where they required fear extinction learning recall. Prior work on ITC connectivity is limited, thus holistic characterization afferent efferent...
The ways in which sensory stimuli acquire motivational valence through association with other is one of the simplest forms learning. Although we have identified many brain nuclei that play various roles reward processing, a significant gap remains understanding how encoding transforms layers processing. To address this gap, carried out comparative investigation mouse anteromedial olfactory tubercle (OT), and ventral pallidum (VP) - 2 connected basal ganglia both been implicated First, using...
SUMMARY In order to respond appropriately threats in the environment, brain must rapidly determine whether a stimulus is important and it positive or negative, then use that information direct behavioral responses. Neurons amygdala have long been implicated valence encoding fear responses threatening stimuli, but show transient firing response these stimuli do not match timescales of associated For decades, there has logical gap how could be mediated without an ensemble representation...
The ways in which sensory stimuli acquire motivational valence through association with other is one of the simplest forms learning. Although we have identified many brain nuclei that play various roles reward processing, a significant gap remains understanding how encoding transforms layers processing. To address this gap, carried out comparative investigation mouse anteromedial olfactory tubercle (OT), and ventral pallidum (VP) - 2 connected basal ganglia both been implicated First, using...
Many forms of electrical excitability expressed in the embryonic nervous system depend on Ca 2+ influx. This discovery has stimulated investigation functions spontaneous elevations intracellular and their roles neuronal development. We present a protocol for imaging different classes transients Xenopus (amphibian) spinal neurons grown dissociated cell culture intact neural tube (the developing cord), focusing early stages differentiation around time closure. The describes methods...
Experience-dependent gene expression reshapes neural circuits, permitting the learning of knowledge and skills. Most involves repetitive experiences during which neurons undergo multiple stages functional structural plasticity. Currently, diversity transcriptional responses underlying dynamic plasticity repetition-based is poorly understood. To close this gap, we analyzed single-nucleus transcriptomes L2/3 glutamatergic primary motor cortex after 3 d skill training or home cage control in...
The ways in which sensory stimuli acquire motivational valence through association with other is one of the simplest forms learning. Though we have identified many brain nuclei that play various roles reward processing, a significant gap remains understanding how encoding transforms layers processing. To address this gap, carried out comparative investigation olfactory tubercle (OT), and ventral pallidum (VP) - 2 connected basal ganglia both been implicated First, using anterograde...