A5017515144- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Health and Medical Research Impacts
- Doctoral Education Challenges and Solutions
- Innovations in Medical Education
- Acute Lymphoblastic Leukemia research
- Light effects on plants
- CRISPR and Genetic Engineering
- Lung Cancer Research Studies
- Advances in Oncology and Radiotherapy
- Childhood Cancer Survivors' Quality of Life
- Cancer therapeutics and mechanisms
- Biomedical and Engineering Education
- Mitochondrial Function and Pathology
- Neurobiology and Insect Physiology Research
- Meta-analysis and systematic reviews
- Neuroscience and Neural Engineering
- ATP Synthase and ATPases Research
- Gut microbiota and health
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neuroblastoma Research and Treatments
University of California, San Francisco
2018-2020
University of California, Los Angeles
2011-2014
University of California System
2012
University of California, San Diego
2008
Neurotransmitter signaling in the mature nervous system is well understood, but functions of transmitters immature are less clear. Although released during embryogenesis regulate neuronal proliferation and migration, little known about their role regulating early differentiation. Here, we show that GABA glutamate drive calcium-dependent embryonic electrical activity regulates transmitter specification. The number neurons expressing different changes when or blocked chronically, either using...
Abstract Background Studies with the nematode model Caenorhabditis elegans have identified conserved biochemical pathways that act to modulate life span. Life span can also be influenced by composition of intestinal microbiome, and C . dramatically its diet Escherichia coli Although is typically fed standard OP50 strain E , nematodes strains rendered respiratory deficient, either due a lack coenzyme Q or absence ATP synthase, show significant extension. Here we explore mechanisms accounting...
Animal development requires temporal coordination between recurrent processes and sequential events, but the underlying timing mechanisms are not yet understood. The molting cycle of C. elegans provides an ideal system to study this basic problem. We recently characterized LIN-42, which is related circadian clock protein PERIOD, as a key component developmental timer rhythmic cycles. In context, LIN-42 coordinates epithelial stem cell dynamics with progression cycle. Repeated actions may...
Abstract Controlling protein activity and localization is a key tool in modern biology. Mammalian steroid receptor ligand-binding domain (LBD) fusions have been used range of organisms cell types to inactivate proteins interest until the cognate ligand applied. Here, we demonstrate that glucocorticoid LBD confers ligand-gated control heterologous gene expression system (Q system) DAF-16 transcription factor Caenorhabditis elegans. These experiments provide powerful for temporal activity,...
<ns4:p><ns4:bold>Background:</ns4:bold> There has been a groundswell of national support for transparent tracking and dissemination PhD career outcomes. In 2017, individuals from multiple institutions professional organizations met to create the Unified Career Outcomes Taxonomy (UCOT 2017), three-tiered taxonomy help uniformly classify outcomes graduates. Early adopters UCOT noted ambiguity in some categories taxonomy, raising questions about its consistent application within across...
<ns4:p><ns4:bold>Background:</ns4:bold> There has been a groundswell of national support for transparent tracking and dissemination PhD career outcomes. In 2017, individuals from multiple institutions professional organizations met to create the Unified Career Outcomes Taxonomy (UCOT 2017), three-tiered taxonomy help uniformly classify outcomes graduates. Early adopters UCOT noted ambiguity in some categories taxonomy, raising questions about its consistent application within across...
ABSTRACT In the past year, there has been an exciting groundswell of national efforts to integrate multiple taxonomies for transparent dissemination and analysis PhD career outcomes. this study, we leveraged unique resources Broadening Experiences in Scientific Training Consortium examine reliability three-tiered Unified Career Outcomes Taxonomy (UCOT v.2017) that was collaboratively developed at a meeting convened by Rescuing Biomedical Research August 2017. Using amended version UCOT...
Abstract Controlling protein activity and localization is a key tool in modern biology. Mammalian steroid receptor ligand-binding domains (LBDs) fusions have been used range of organisms cell-types to inactivate proteins interest until the cognate ligand applied. Here, we demonstrate that glucocorticoid LBD confers ligand-gated control heterologous gene expression system (Q system) DAF-16 transcription factor C. elegans . These experiments provide powerful for temporal activity, will bolster...