A5007210449- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- RNA and protein synthesis mechanisms
- Cardiac Imaging and Diagnostics
- ATP Synthase and ATPases Research
- Bacterial Genetics and Biotechnology
- Ion channel regulation and function
- Immune Response and Inflammation
- Mitochondrial Function and Pathology
- Thyroid Disorders and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging and Pathology Studies
- Cancer Treatment and Pharmacology
- Heart Rate Variability and Autonomic Control
- Advanced Radiotherapy Techniques
- Cardiovascular Disease and Adiposity
- Oral Health Pathology and Treatment
- Yersinia bacterium, plague, ectoparasites research
- Ion Transport and Channel Regulation
- Advanced MRI Techniques and Applications
- Bacillus and Francisella bacterial research
The Ohio State University
2020-2025
The Ohio State University Wexner Medical Center
2025
Lung Institute
2021-2022
University of California, Los Angeles
2013-2017
Salk Institute for Biological Studies
2014-2015
Neurobehavioral Systems
2014-2015
UCLA Health
2015
Neurological Surgery
2011
University of California, San Francisco
2011
Aminoacyl-tRNA synthetases use a variety of mechanisms to ensure fidelity the genetic code and ultimately select correct amino acids be used in protein synthesis. The physiological necessity these quality control different environments remains unclear, as cost vs benefit accurate synthesis is difficult predict. We show that Escherichia coli, non-coded acid produced through oxidative damage significant threat accuracy must cleared by phenylalanine-tRNA synthetase order prevent cellular...
The relationship between hypothyroidism and the occurrence progression of heart failure (HF) has had increased interest over past years. low T3 syndrome, a reduced in presence normal thyroid stimulating hormone (TSH), free T4 concentration, is strong predictor all-cause mortality HF patients. Still, impact on contractile properties failing human myocardium unknown. Our study aimed to investigate that using ex-vivo assessment force kinetics contraction/relaxation left ventricular intact...
Seizures are important neurological complications after traumatic brain injury (TBI) and reported for up to 50% of patients with TBI. Despite several studies, no drug strategy has been able alter the biological events leading epileptogenesis. The glial water channel, aquaporin-4 (AQP4), was shown facilitate cytotoxic cell swelling in ischemia scar formation stab wound injury. In this study, we examined post-traumatic seizure susceptibility AQP4-deficient mice (AQP4–/–) injection...
Glutathionylation, the formation of reversible mixed disulfides between glutathione and protein cysteine residues, is a posttranslational modification previously observed for intracellular proteins bacteria. Here we show that Yersinia pestis LcrV, secreted capping type III secretion machine, glutathionylated at Cys273 this promotes association with host ribosomal S3 (RPS3), moderates Y. effector transport killing macrophages, enhances bubonic plague pathogenesis in mice rats. Secreted LcrV...
Abstract Sinusitis is a cause of significant morbidity, substantial healthcare costs, and negative effects on quality life. The primary objective this study to characterize the previously unknown lipid profile sinonasal mucosa from patients with chronic rhinosinusitis (CRS) controls. Sinus samples were analyzed 9 CRS concomitant nasal polyps, 11 without 12 Ten lone polyp also analyzed. Samples subjected modified Bligh/Dyer extraction, then high performance thin layer chromatography (HPTLC),...
The two main phases of the mammalian cardiac cycle are contraction and relaxation; however, whether there is a connection between them in humans not well understood. Routine exercise has been shown to improve function, morphology, molecular signatures. Likewise, acute chronic changes that occur heart response injury, disease, stress characterized, albeit fully In this study, we investigated how myocardial injury affect contraction-relaxation coupling. We retrospectively analyzed correlation...
<b>Introduction</b> Chronic otomastoiditis causes pain, otorrhea, and hearing loss resulting from the growth of tissue within normally hollow mastoid cavity. <b>Objectives</b> In this report, we used a lipidomics approach to profile major bone lipids patients with without otomastoiditis. <b>Methods</b> The dust created during mastoidectomy, as well tissue, was analyzed seven patients. Bone also collected in an additional four otologic cases (parotidectomy requiring mastoidectomy). Samples...
Introduction: Anthracyclines are used effectively to treat many cancers. However, cumulative and irreversible cardiotoxicity can limit anthracyclines’ clinical benefit. Mechanisms of have been assessed in murine models, but no studies directly assess human heart contractility. Our objective was left ventricular contractile force, kinetics contraction relaxation, frequency-dependent activation anthracycline-induced failing myocardium. Methods: From 2009-2019, we live tissue-level forces...
Introduction: It remains unclear if body mass index (BMI) is correlated to the amount of cardiac adipose tissue in humans. Echocardiography typically utilized measure epicardial fat live patients, but has yielded inconclusive results, as it difficult levels from a single location on 1-dimensional image, not always distributed equally across heart. Methods: Through Ohio State Cardiac Research Tissue program, we have collected over 200 human hearts various conditions. Multi-angle photographs...
The two main phases of the mammalian cardiac cycle are contraction and relaxation; however, whether these linked in human myocardium is not well understood. Prior investigations have shown that structural biochemical myocardial remodeling secondary to exercise training and/or infarction does disrupt contraction-relaxation (CR) coupling canine model system. In addition, a wide variety murine transgenic models targeting EC coupling, between relaxation was unaltered. Given vast differences...