A5101474968- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- PI3K/AKT/mTOR signaling in cancer
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Renal and related cancers
- Advanced biosensing and bioanalysis techniques
- Bioactive Compounds and Antitumor Agents
- Neurogenesis and neuroplasticity mechanisms
- Phytochemistry and biological activity of medicinal plants
- Extracellular vesicles in disease
- Hedgehog Signaling Pathway Studies
- Mitochondrial Function and Pathology
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Axon Guidance and Neuronal Signaling
- Barrier Structure and Function Studies
Hangzhou First People's Hospital
2015-2024
Huazhong University of Science and Technology
2017-2024
Wuhan University
2015-2024
University of Nottingham Ningbo China
2024
Tongji Hospital
2017-2024
Zhejiang University
2020-2023
Guangdong Provincial People's Hospital
2021-2023
Guangdong Academy of Medical Sciences
2021-2023
Southern Medical University
2023
Yale University
2017-2022
Due to its simplicity, versatility, and high efficiency, the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 technology has emerged as one of most promising approaches for treatment a variety genetic diseases, including human cancers. However, further translation CRISPR/Cas9 cancer gene therapy requires development safe efficient, highly specific delivery both Cas9 single guide RNA tumors. Here, novel core-shell nanostructure, liposome-templated hydrogel nanoparticles...
Abstract Cell membrane coating has recently emerged as a promising biomimetic approach to engineering nanoparticles (NPs) for targeted drug delivery. However, simple cell may not meet the need efficient delivery brain. Here, novel molecular strategy modify surface of NPs with enhanced brain penetration is reported. By using poly(lactic‐ co ‐glycolic) acid model, it shown that ischemic through neural stem cells (NSCs), and efficiency can be further increased isolated from NSCs engineered...
Current treatments for ischemic stroke are insufficient. The lack of effective pharmacological approaches can be mainly attributed to the difficulty in overcoming blood–brain barrier. Here, we report a simple strategy synthesize protease-responsive, brain-targeting nanoparticles improved treatment stroke. resulting respond proteases enriched microenvironment, including thrombin or matrix metalloproteinase-9, by shrinking expanding their size. Targeted delivery was achieved using surface...
Abstract Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor. The unregulated expression of Claudin-4 (CLDN4) plays an important role in tumor progression. However, biological CLDN4 GBM still unknown. This study aimed to determine whether mediates glioma progression, if so, it would further explore molecular mechanisms carcinogenesis. Our results revealed that was significantly upregulated specimens cells. inhibition CLND4 could inhibit mesenchymal...
Stroke is the leading cause of death and disability. Currently, there no effective pharmacological treatment for this disease, which can be partially attributed to inability efficiently deliver therapeutics brain. Here we report development natural compound-derived nanoparticles (NPs), function both as a potent therapeutic agent stroke an efficient carrier drug delivery ischemic First, screened collection nanomaterials identified betulinic acid (BA) one most antioxidants treatment. Next,...
Stem cells offer new therapeutic avenues for the repair and replacement of damaged tissues organs owing to their self-renewal multipotent differentiation capabilities. In this paper, we conduct a systematic review characteristics various types stem insights into potential applications in both cellular cell-free therapies. addition, provide comprehensive summary technical routes cell therapy discuss detail current challenges, including safety issues control. Although some remain, demonstrates...
Stroke is a deadly disease without effective pharmacotherapies, which due to two major reasons.First, most therapeutics cannot efficiently penetrate the brain.Second, single agent pharmacotherapy may be insufficient and treatment of stroke requires targeting multiple complementary targets.Here, we set develop component, multifunctional nanoparticles (NPs) for targeted delivery glyburide brain treatment. Methods:To characterize penetrability, radiolabeled glyburide, intravenously administered...
Glioblastoma (GBM) is the most common and fatal primary tumor in central nervous system (CNS). Due to existence of blood-brain barrier (BBB), therapeutics cannot efficiently reach tumors brain, as a result, they are unable be used for effective GBM treatment. Accumulating evidence shows that delivery form nanoparticles (NPs) may allow crossing BBB
Androgen-deprivation therapy (ADT) via targeting androgens/androgen receptor (AR) signals may suppress cell proliferation in both prostate cancer (PCa) and bladder (BCa), yet its impact on the invasion of these two urological cancers remains unclear. Here we found androgens/AR with either recently developed antiandrogen Enzalutamide (Enz) or AR-shRNAs led to increase PCa invasion, decrease BCa invasion. Mechanistic dissection revealed that suppressing could result differential alterations...
Abstract Breast cancer brain metastases (BCBMs) represent a major cause of morbidity and mortality among patients with breast cancer. Chemotherapy, which is widely used to treat tumors outside the brain, often ineffective on BCBMs due its inability efficiently cross blood‐brain barrier (BBB). Although BBB partially disrupted in tumor lesions, it remains intact enough prevent most therapeutics from entering brain. Here, nanotechnology approach reported that can overcome through synthesis...
Despite being promising, the clinical application of magnetic hyperthermia for brain cancer treatment is limited by requirement highly invasive intracranial injections. To overcome this limitation, here we report development gallic acid-coated nanoclovers (GA-MNCs), which allow not only noninvasive delivery but also targeted systemic chemotherapy to tumors. GA-MNCs are composed clover-shaped MNCs in core, can induce heat high efficiency, and polymerized GA on shell, enables tumor...
Abstract Next-generation hormone agents (NHAs) such as abiraterone and enzalutamide have become standard treatments for castration-resistant prostate cancer (CRPC), significantly prolonging patient survival. However, resistance to NHAs inevitably develops, presenting a critical unmet clinical challenge. Inhibition of CYP11A1 disrupts the entire biosynthesis pathway androgens other steroids by blocking formation pregnenolone. This mechanism halts activation androgen receptor (AR) axis,...
Abstract Gastrointestinal stromal tumor (GIST) is the critically mesenchymal malignancy inhabiting GI tract, which crucially induced by receptor tyrosine kinase (KIT) gene mutation. Although inhibitors (TKIs), such as imatinib has prolonged survival significantly, intrinsic and acquired resistance still disturbed more than 20% patients. Therefore, significant unmet medical remains needed. phosphodiesterase 3A (PDE3A)- Schlafen family member 12 (SLFN12) molecular glue a novel anti-tumor...
The aim of the present study was to examine anticarcinogenic effects emodin on Notch signaling pathway and vascular endothelial growth factor (VEGF) in PC3 androgen-independent prostate cancer cell line vitro. viability assessed using an 3‑(4,5)‑dimethylthiahiazo(‑z‑y1)‑3,5‑di‑phenytetrazolium bromide assay. Cell apoptosis cycle were detected flow cytometry. Morphological alterations observed transmission electron microscopy. mRNA protein expression levels Notch1, Jagged1, VEGF bFGF reverse...
Despite being effective for many other solid tumors, traditional anti-angiogenic therapy has been shown to be insufficient the treatment of malignant glioma. Here, we report development polyphenol nanoparticles (NPs), which not only inhibit formation new vessels but also enable targeted disruption existing tumor vasculature. The NPs are synthesized through a combinatory iron-coordination and polymer-stabilization approach, allows high drug loading intrinsic vessel targeting. We study lead NP...