A5048469154- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Cardiac Ischemia and Reperfusion
- Neurological Disease Mechanisms and Treatments
- Advanced Glycation End Products research
- Ferroptosis and cancer prognosis
- Heme Oxygenase-1 and Carbon Monoxide
- Circadian rhythm and melatonin
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- Cell death mechanisms and regulation
- Anesthesia and Neurotoxicity Research
- Vagus Nerve Stimulation Research
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Traumatic Brain Injury and Neurovascular Disturbances
- Eicosanoids and Hypertension Pharmacology
- Melanoma and MAPK Pathways
- Sirtuins and Resveratrol in Medicine
- Traditional Chinese Medicine Analysis
- Organ Transplantation Techniques and Outcomes
- Cancer Mechanisms and Therapy
- Intracranial Aneurysms: Treatment and Complications
- NF-κB Signaling Pathways
- Immune cells in cancer
Wuhan University
2016-2025
Renmin Hospital of Wuhan University
2016-2025
Hebei Medical University
2019-2025
Second Hospital of Hebei Medical University
2019-2025
Shandong University
2018-2025
Shandong Provincial Hospital
2025
Shandong First Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Shandong Maternal and Child Health Hospital
2025
Beaumont Hospital, Royal Oak
2024
Glioblastoma multiforme (GBM) is the most common and fatal primary malignant central nervous system tumor in adults. Although there are multiple treatments, median survival of GBM patients unsatisfactory, which has prompted us to continuously investigate new therapeutic strategies, including drugs drug delivery approaches. Ferroptosis, a kind regulated cell death (RCD), been shown be dysregulated various tumors, GBM. Fatostatin, specific inhibitor sterol regulatory element binding proteins...
Background Severe renal ischemia and reperfusion injury (IRI) progresses to interstitial fibrosis (RIF) with limited therapeutic strategies. Although ferrptosis macrophage polarization both play important roles in this model, their specific pathogenesis interactions have not been elucidated. Therefore, we aimed explore the mechanisms by which ferrotosis occurs tubular epithelial cells (RTECs) ferroptotic cell-derived exosomes induce IRI-related RIF model. Methods In vivo , C57BL/6J mice were...
Abstract Background Inhibition of p38 MAPK signalling leads to glioblastoma multiform (GBM) tumourigenesis. Nevertheless, the molecular mechanism that induces pathway silencing during GBM genesis has yet be determined. Identifying new factors can regulate is important for tumour treatment. Methods Flow cytometry, TUNEL assays, immunofluorescence, JC-1 and western blot analyses were used detect apoptosis cells. The specific methods autophagy levels in cells analysis, LC3B protein puncta...
Glioblastoma (GBM) is the most common and fatal primary tumor in central nervous system (CNS). Due to existence of blood-brain barrier (BBB), therapeutics cannot efficiently reach tumors brain, as a result, they are unable be used for effective GBM treatment. Accumulating evidence shows that delivery form nanoparticles (NPs) may allow crossing BBB
Timely and accurate prediction of delayed cerebral ischemia is critical for improving the prognosis patients with aneurysmal subarachnoid hemorrhage. Machine learning (ML) algorithms are increasingly regarded as having a higher power than conventional logistic regression (LR). This study aims to construct LR ML models compare their on (DCI) after hemorrhage (aSAH).This was multicenter, retrospective, observational cohort that enrolled from five hospitals in China. A total 404 aSAH were...
Decreased sex hormone-binding globulin (SHBG) expression is an independent risk factor for gestational diabetes mellitus(GDM).However, the mechanisms that link low SHBG and insulin resistance in GDM unclear. In this study, we investigated placenta PI3K/AKT pathway to reveal mechanism links decreased resistance. A cells model was established by method of stimulation. Two groups were set up, HTR8/Svneo insulin-resistance HTR8/SVneo. The associated factors detected using real-time PCR western...
Emerging evidence indicates that gamma-aminobutyric acid (GABA) has many beneficial effects such as ameliorating immune and inflammatory response. But, here we reported activation of GABAA Rs aggravated dextran sodium sulfate (DSS)-induced colitis although the expression pro-inflammatory cytokines was inhibited. In contrast, blocking markedly alleviated DSS-induced colitis. Notably, GAD 65/67 were significantly increased in colon mucosa UC patients mouse model Further studies showed GABA...
Kidney in diabetic state is more sensitive to ischemic acute kidney injury (AKI). However, the underlying mechanisms remain unclear. Herein, we examined impact of diabetes mellitus on thioredoxin‐interacting protein (TXNIP) expression and whether mediated NLRP3 activation was associated with renal ischemia/reperfusion‐ (I/R‐) induced AKI. In an vivo model, streptozotocin‐induced rats showed higher susceptibility I/R increased TXNIP expression, which significantly attenuated by resveratrol...
Objective. Intestinal ischemia reperfusion (II/R) injury plays a critical role in remote organ dysfunction, such as lung injury, which is associated with nuclear factor erythroid 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. In the present study, we tested whether ginsenoside Rb1 attenuated II/R induced by Nrf2/HO-1 Methods. was male C57BL/6J mice 45 min of superior mesenteric artery (SMA) occlusion followed hours reperfusion. Ginsenoside administrated prior to or without...
Aims . Ischemic postconditioning (IPO) has a strong protective effect against intestinal ischemia-reperfusion (IIR) injury that is partly related to autophagy. However, the precise mechanisms involved are unknown. Methods C57BL/6J mice were subjected unilateral IIR with or without IPO. After 45 min ischemia and 120 reperfusion, tissues blood collected for examination. HE staining Chiu’s score used evaluate pathologic injury. We test markers of barrier function oxidative stress. Finally, we...
Chronic manganese (Mn) exposure can disturb mitochondrial homeostasis leading to dysfunction, which is involved in Mn-induced neurodegenerative diseases. Resveratrol (RSV), as a promoter of biogenesis, plays significant role against dysfunction. However, whether RSV relieve neuronal injury and dysfunction remains unknown. Sirtuin 3 (SIRT3), main sirtuin, an important regulator mitochondria maintain homeostasis. Therefore, this study investigated SIRT3 was required for alleviating primary...
Ginsenoside Rb1 (RB1), the most clinically effective constituent of ginseng, possesses a variety biological activities. The objectives this study were to investigate protective effects RB1 and its underlying mechanism on renal injury induced by intestinal ischemia-reperfusion (IIR) in mice. was administered prior inducing IIR achieved occluding superior mesenteric artery for 45 min followed 120 reperfusion. All-trans-retinoic acid (ATRA) used as an inhibitor NF-E2-related factor-2 (Nrf2)...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is responsible for over 20,000 deaths every year in United States. Most of the are due, large part, to its propensity metastasize. We have examined effect bioactive component grape seed proanthocyanidins (GSPs) on human cutaneous HNSCC invasion molecular mechanisms underlying these effects using SCC13 line as an vitro model. Methods The therapeutic GSPs cancer were studied Boyden chamber wound healing assays. levels various...
The nuclear erythroid 2‑related factor 2 (NRF2)/antioxidant response element (ARE) pathway has been shown to provide strong protection against oxidative stress injury induced by renal ischemia‑reperfusion (IR). However, the endogenous regulatory mechanism of NRF2/ARE in IR is incompletely understood. A rat model was established occlusion bilateral pedicle for 45 min, followed reperfusion 24 h. Renal assessed light microscopy and levels serum creatinine, blood urea nitrogen neutrophil...
Ferroptosis is an iron dependent cell death closely associated with p53 signaling pathway and aberrantly regulated in glioblastoma (GBM), yet the underlying mechanism needs more exploration. Identifying new factors which regulate ferroptosis GBM essential for treatment.Glioma growth was evaluated by viability assays colony formation assays. Lipid reactive oxygen species (ROS) assays, lipid peroxidation glutathione transmission electron microscopy were used to assess degree of cellular GBM....
Abstract Background Mitochondria represent a major source of reactive oxygen species (ROS) in cells, and the direct increase ROS content is primary cause oxidative stress, which plays an important role tumor proliferation, invasion, angiogenesis, treatment. However, relationship between mitochondrial stress-related genes glioblastoma (GBM) remains unclear. This study aimed to investigate value mitochondria prognosis therapeutic targets GBM. Methods We retrieved from several public databases....
Ferroptosis is involved in ischemia and reperfusion injury (IRI) of transplanted kidney. Understanding the molecular mechanisms ferroptosis essential to elucidate pathogenesis IRI. 1307 differentially expressed genes (DEGs) were obtained by GSE90861 retrieved from GEO database. 29 ferroptosis-related DEGs intersection with FerrDb database, which subjected enrichment analysis cytoHubba plugin for selecting top three (IL6, ATF3 JUN) as hub genes. Next, ROC showed good diagnostic prospects both...
Glioblastoma multiforme (GBM) is the most prevalent and lethal primary intracranial neoplasm in adult population, with treatments of limited efficacy. Recently, bufotalin has been shown to have anti-cancer activity a variety cancers. This investigation aims investigate effect on GBM elucidate its potential underlying mechanism. Our results show that not only inhibits proliferation epithelial-mesenchymal transition (EMT) but also triggers apoptosis cells. The result RNA-seq indicated could...
Gastric pain has limited treatment options and the mechanisms within central circuitry remain largely unclear. This study investigates in gastric induced by noxious distension (GD) mice. Here, we identified that nucleus tractus solitarius (NTS) serves as first-level center of pain, primarily via vagus nerve. The prelimbic cortex (PL) is engaged perception pain. lateral parabrachial (LPB) paraventricular thalamic (PVT) are crucial regions for synaptic transmission from NTS to PL....
Genetic diagnosis of ADPKD has been challenging due to the variant heterogeneity, presence duplicated segments, and high GC content exon 1 in PKD1. In our reproductive center, 40 patients were still genetically undiagnosed or diagnosed without single-nucleotide resolution after testing with a short-read sequencing panel 312 phenotype. A combination long-range PCR long-read approach for PKD1 was performed on these patients. LRS additionally identified 10 pathogenic likely variants, including...
Diabetic cardiomyopathy (DC) is a serious complication in patients with type 1 diabetes mellitus and has become growing public health problem worldwide. There evidence that endoplasmic reticulum stress (ERS) involved the pathogenesis of DC, related diagnostic markers have not been well-studied. Therefore, this study aimed to screen ERS-related genes (ERGs) potential value DC. Gene expression data on DC were downloaded from GEO database, ERGs obtained The Ontology knowledgebase. Limma package...