A5004802781- Gestational Diabetes Research and Management
- Pancreatic and Hepatic Oncology Research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gastric Cancer Management and Outcomes
- Pharmacological Effects of Natural Compounds
- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis B Virus Studies
- Preterm Birth and Chorioamnionitis
- Liver Disease Diagnosis and Treatment
- Plant and Fungal Species Descriptions
- Hepatitis C virus research
- Ovarian cancer diagnosis and treatment
- Pregnancy-related medical research
- Forest, Soil, and Plant Ecology in China
- Pancreatitis Pathology and Treatment
- Maternal and Perinatal Health Interventions
- Nosocomial Infections in ICU
- Vitamin K Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Ecology and Conservation Studies
Xinxiang Medical University
2025
Jinan University
2020-2021
China Medical University
2005-2020
First Affiliated Hospital of Wenzhou Medical University
2012-2019
Wenzhou University
2019
Wenzhou Medical University
2012-2019
Southeast University
2017
Changhai Hospital
1996-2014
Second Military Medical University
1996-2014
Wuhan University
2010
Decreased sex hormone-binding globulin (SHBG) expression is an independent risk factor for gestational diabetes mellitus(GDM).However, the mechanisms that link low SHBG and insulin resistance in GDM unclear. In this study, we investigated placenta PI3K/AKT pathway to reveal mechanism links decreased resistance. A cells model was established by method of stimulation. Two groups were set up, HTR8/Svneo insulin-resistance HTR8/SVneo. The associated factors detected using real-time PCR western...
BACKGROUND TaohongSiwu decoction (THSWT), a traditional herbal formula, has been used to treat cardiovascular and cerebrovascular diseases such as essential hypertension (EH) in China. However, the pharmacological mechanism is not clear. To investigate mechanisms of THSWT treatment EH, we performed compounds, targets prediction network analysis using pharmacology method. MATERIAL AND METHODS We selected chemical constituents according TCMSP UniProtKB databases collected therapeutic on EH...
<b>Background</b>: There is a lack of consensus on how endoscopic ultrasound (EUS) guided pseudocyst drainage should be performed. This survey was carried out amongst members the Asian Endoscopic Ultrasonography Group (AEG) to describe their practices in performing this procedure. <b>Methods</b>: an Asia wide multi-institutional EUS group conducted between November and December 2013. The responses 19-question with regard practice were obtained. <b>Results</b>: In total, 19 endoscopists...
Hepatic injury after cardiac surgery is considered to be a consequence of cardiopulmonary bypass (CPB). The aim this study was test the hypothesis that penehyclidine hydrochloride (PHC) could attenuate hepatic using rat CPB model.Male Sprague-Dawley rats were randomly divided into six groups (eight per group), including sham-operated control, sham low-dose PHC control (0.6 mg kg), high-dose (2.0 vehicle kg) and kg)-treated groups. Blood samples collected from femoral artery at cessation...
Objective. To investigate the influence of gestational diabetes mellitus (GDM) on change SHBG in fetus.
We reviewed the outcome for 211 women undergoing a planned en caul (within intact membranes) cesarean section and 836 control with conventional lower segment section, in period 2001-2010 at university-affiliated hospital China, where former technique has been practiced. Of intended sections there were 141 successful deliveries (66.8%), 70 that failed converted to section. Maternal blood loss was similar both operation types, but rate of asphyxia significantly among preterm infants delivered...
Vitamin K 2 (VK2), found to act treat hypertension, has been widely used in the food and pharmaceutical industries nowadays. However, potential targets molecular mechanisms of VK2 for salt-sensitive hypertension have not fully investigated. Therefore, study aimed investigate using network pharmacology 16S rRNA sequencing strategy. The pharmacology-based findings from KEGG enrichment analysis revealed that VK2-treated was mechanically associated with complement coagulation cascades, calcium...
To compare the expression of sex hormone binding globulin (SHBG) in normal placental tissues with from patients gestational diabetes mellitus (GDM) and to deduce mechanism affecting SHBG GDM.We detected localization measured mRNA protein using immunohistochemistry, reverse-transcription polymerase chain reaction, Western blotting, respectively, GDM tissues. The distribution cells was examined immune electron microscopy.Compared controls, group displayed disordered cell surface microvilli...
Abstract Aim This study was conducted to investigate the effects of sex hormone‐binding globulin (SHBG) on glucose metabolism and insulin resistance in human placental trophoblasts involvement cAMP/PKA/CREB1 signaling pathway these effects. Methods An cell model established. SHBG‐overexpression plasmid transfected into cells, expression transporter 1 (GLUT1), CREB p‐CREB detected analyzed normal cells all groups by real‐time PCR western blotting; cAMP, PKA, consumption pyruvic acid levels...
Sex hormone-binding globulin (SHBG) has a key role in the occurrence and development of gestational diab-etes mellitus (GDM). Single nucleotide polymorphism (SNP) rs6259 is functional site SHBG gene, which suspected to regulate level. The present study explored placental SNP distribution Chinese pregnant women influence on concentrations, assess relationship GDM. We screened allele 210 healthy 180 GDM gravidas by PCR-RFLP restriction enzyme measured concentrations each genotypic group with...
Wenjinghuoluo (WJHL) prescription, the typical rheumatoid arthritis (RA) treatment compound in traditional Chinese medicine, shows favorable efficacy. The precise mechanism of WJHL on RA therapy is yet to be elucidated. This study aimed determine metabolic biomarkers early onset and evaluate regulation effect metabolite levels. Multivariate statistical analysis identified 93 by MS/MS. These played an important role key pathways associated with collagen-induced (CIA). A total 68 were related...