A5081201856- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Signaling Pathways in Disease
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Neurogenesis and neuroplasticity mechanisms
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Cancer Research and Treatments
- Circular RNAs in diseases
- Bioactive Compounds and Antitumor Agents
- Carbon and Quantum Dots Applications
- Cancer, Lipids, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytokine Signaling Pathways and Interactions
- Cancer, Stress, Anesthesia, and Immune Response
- Drug Transport and Resistance Mechanisms
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Single-cell and spatial transcriptomics
Yale University
2020-2025
Xi'an Medical University
2014-2025
Xuzhou Medical College
2024
Shanghai Jiao Tong University
2014-2020
Air Force Medical University
2012-2020
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2014
Nantong University
2012
Institute of Botany
2010
Chinese Academy of Sciences
2010
Shanghai Institutes for Biological Sciences
2010
Malignant gliomas are the most common central nervous system tumors and molecular mechanism driving their development recurrence is still largely unknown, limiting treatment of this disease. Here, we show that restoring expression miR-218, a microRNA commonly downregulated in glioma, dramatically reduces migration, invasion, proliferation glioma cells. Quantitative reverse transcription PCR Western blotting analysis revealed stem cell-promoting oncogene Bmi1 was decreased after...
Abstract Grass plants develop distinct inflorescences and spikelets that determine grain yields. However, the mechanisms underlying specification of in grasses remain largely unknown. Here, we report biological role one SEPALLATA (SEP)-like gene, OsMADS34, controlling development rice (Oryza sativa). OsMADS34 encodes a MADS box protein containing short carboxyl terminus without transcriptional activation activity yeast cells. We demonstrate ubiquitous expression roots, leaves, primordia...
Temozolomide (TMZ) is the first-line chemotherapy drug that has been used to treat glioma for over a decade, but benefits are limited by half of treated patients who acquired resistance. Studies have shown TMZ resistance complex process with multiple factors, which not fully elucidated. Ferroptosis, new type cell death discovered in recent years, reported play an important role tumor The present study reviews relationship between ferroptosis and resistance, highlights Finally, investigators...
Abstract Glioblastoma (GBM) is the most aggressive tumor of central nervous system and remains universally lethal due to lack effective treatment options their inefficient delivery brain. Here development multifunctional polymeric nanoparticles (NPs) for GBM reported. The NPs are synthesized using a novel glutathione (GSH)‐reactive poly (2,2″‐thiodiethylene 3,3″‐dithiodipropionate) (PTD) polymer engineered brain penetration through neutrophil elastase‐triggered shrinkability, iRGD‐mediated...
Ferroptosis is a newly discovered type of cell death decided by iron-dependent lipid peroxidation, but its role in glioblastoma remains unclear. Ibuprofen, nonsteroidal anti-inflammatory drug (NSAID), has been associated with antitumorigenic effects many cancers. In this study, we first found that ibuprofen inhibited the viabilities cells vitro and vivo, accompanied abnormal increase intracellular peroxidation. Further study showed growth inhibition caused could be rescued ferroptosis...
DNA dioxygenases Ten-Eleven Translocation (TET) proteins can catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), and thereby alter epigenetic state DNA. The TET family includes TET1, TET2 TET3 members in mammals. Recently, accumulative research uncovered that TET1–3 occur abundantly central nervous system (CNS), their biological functions have just begun be investigated. In present study, we demonstrated mRNA protein were highly expressed cerebral cortex...
Abstract Ten-eleven translocation (TET) proteins, the dioxygenase for DNA hydroxymethylation, are important players in nervous system development and diseases. However, their role myelination remyelination after injury remains elusive. Here, we identify a genome-wide locus-specific hydroxymethylation landscape shift during differentiation of oligodendrocyte-progenitor cells (OPC). Ablation Tet1 results stage-dependent defects oligodendrocyte (OL) mouse brain. The mice lacking lineage develop...
Abstract Ischemic stroke is a leading cause of death and disability remains without effective treatment options. Improved requires efficient delivery multimodal therapy to ischemic brain tissue with high specificity. Here, this article reports the development multifunctional polymeric nanoparticles (NPs) for both drug delivery. The NPs are synthesized using an reactive oxygen species (ROS)‐reactive poly (2,2′‐thiodiethylene 3,3′‐thiodipropionate) (PTT) polymer engineered penetration through...
Abstract Glioblastoma (GBM) is a deadly disease without effective treatment. Because glioblastoma stem cells (GSCs) contribute to tumor resistance and recurrence, improved treatment of GBM can be achieved by eliminating GSCs through inducing their differentiation. Prior efforts have been focused on studying GSC differentiation towards the astroglial lineage. However, regulation neuronal oligodendroglial lineages largely unknown. To identify genes that control all three lineages, we performed...
Nucleic acid–mediated signaling triggers an immune response that is believed to be central the pathophysiology of autoimmunity in systemic lupus erythematosus (SLE). Here, we found a cell-penetrating, SLE-associated antiguanosine autoantibody may present therapeutic opportunities for cancer treatment. The entered cells through nucleoside salvage-linked pathway membrane transit avoids endosomes and lysosomes bound endogenous RNA live cells. In orthotopic models glioblastoma, antibody...
Glioblastoma multiforme (GBM; WHO grade IV) is one of the most common primary tumors central nervous system. This disease remains incurable human malignancies because molecular mechanism driving GBM development and recurrence still largely unknown. Here, we show that knockdown lymphocyte enhancer factor-1 (LEF1), a major transcription factor Wnt pathway, inhibits U251 cell migration, invasion, proliferation. Furthermore, downregulation LEF1 expression self-renewal capacity stem-like cells...
Involvements of microRNA-22 (miR-22) in cancer development have attracted much attention, but its role tumorigenesis gastric is still largely unknown. Therefore, the aim this study was to investigate expression patterns and clinical implications miR-22 cancer.Quantitative RT-PCR performed evaluate levels 98 pairs normal adjacent mucosa.Compared with mucosa, significantly downregulated tissues (P < 0.001). Of patients cancer, 58 (59.2%) were placed low group 40 (40.8%) high group. In...
Ubiquitin‐specific protease 22 ( USP 22) is a member of the “death‐from‐cancer” signature, which plays key role in cancer progression. Previous evidence has shown that overexpressed and correlates with poor prognosis glioma. The effect mechanism glioma malignancy, especially stemness, remain elusive. Herein, we find more enriched stem‐like tumorspheres than differentiated cells. knockdown inhibits stemness cell lines. With cell‐penetrating TAT ‐tag protein, B cell‐specific Moloney murine...
Increasing evidence indicates that the inflammatory tumor microenvironment can lead to cancer cell metastasis. Shikonin, which is extracted from Chinese herb Zicao (the dried root of Lithospermum erythrorhizon), possesses various pharmacological effects, but its effect on metastasis in remains unknown. In present study, we aimed investigate potential shikonin an as well underlying molecular mechanisms. It was found that, simulated by THP‑1 conditioned medium (THP‑1‑CM) vitro, significantly...
Glioblastoma(GBM) is one of the most common and aggressive malignant primary tumors central nervous system mitochondria have been proposed to participate in GBM tumorigenesis. Previous studies identified a potential role Disrupted Schizophrenia 1 (DISC1), multi-compartmentalized protein, mitochondria. But whether DISC1 could regulate tumorigenesis via still unknown. We determined expression level by both bioinformatics analysis tissue analysis, found that was highly expressed GBM. Knocking...
Rapamycin is clinically used as an immunosuppressant. Increasing evidence suggests that rapamycin has important inhibitory role in the development and progression of different types cancer it a promising candidate for chemotherapy. Berberine isoquinoline alkaloid isolated from medicinal plant species, which been traditional Chinese medicine with no significant side effects. Recent research demonstrated berberine anticancer activity against various cancer, mediated through suppression...