A5101512675- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Global Trade and Competitiveness
- Circular RNAs in diseases
- Global trade and economics
- ATP Synthase and ATPases Research
- Gene expression and cancer classification
- Ovarian cancer diagnosis and treatment
- Cancer-related gene regulation
- Collaboration in agile enterprises
- HER2/EGFR in Cancer Research
- Caveolin-1 and cellular processes
- Ion Transport and Channel Regulation
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Inflammatory Biomarkers in Disease Prognosis
- DNA Repair Mechanisms
- Ship Hydrodynamics and Maneuverability
- Bioinformatics and Genomic Networks
Sichuan University
2003-2025
West China Second University Hospital of Sichuan University
2018-2025
Chinese Academy of Sciences
2025
Kunming Institute of Botany
2025
Fujian Provincial Cancer Hospital
2024
Fujian Medical University
2024
University of Hong Kong
2023
Air Force Medical University
2009-2023
Shanghai Jiao Tong University
2013-2023
University of Hong Kong - Shenzhen Hospital
2023
Malignant gliomas are the most common central nervous system tumors and molecular mechanism driving their development recurrence is still largely unknown, limiting treatment of this disease. Here, we show that restoring expression miR-218, a microRNA commonly downregulated in glioma, dramatically reduces migration, invasion, proliferation glioma cells. Quantitative reverse transcription PCR Western blotting analysis revealed stem cell-promoting oncogene Bmi1 was decreased after...
Glioblastoma multiforme (GBM) is the most common primary malignant tumors originating in brain parenchyma. At present, GBM patients have a poor prognosis despite continuous progress therapeutic technologies including surgery, radiotherapy, photodynamic therapy, and chemotherapy. Recent studies revealed that miR-101 was remarkably down-regulated kinds of human cancers associated with aggressive tumor cell proliferation stem self-renewal. Data also showed glioma samples lines, but underlying...
The presence of specific genetic mutations in patients with glioblastoma multiforme (GBM) is associated improved survival outcomes. Disruption the DNA damage response (DDR) pathway tumor cells enhances effectiveness radiotherapy drugs, while increased mutational burden following cell also facilitates efficacy immunotherapy. ATRX gene, located on chromosome X, plays a crucial role DDR. aim this research to elucidate correlation between and GBM. Dataset obtained from TCGA-GBM were conducted an...
In cancer, glycolysis driving enzymes and their regulating microRNAs are one of the key focus oncology research lately. The glycolytic enzyme hexokinase 2 (HK2) is crucial for Warburg effect in human glioma, most common malignant brain tumor. present study, we studied tumorigenic role HK2 clarified mechanism miR-218 induced regulation glioma development. expression patient derived non neoplastic tissue was quantified. silenced U87 U251 cell lines were assessed proliferation, migration...
In head and neck squamous cell carcinoma (HNSC), chemoresistance is a major reason for poor prognosis. Nevertheless, there lack of validated biomarkers to screen patients categorical chemotherapy. Fc gamma binding protein (FCGBP) mucus associated with mucosal epithelial cells has immunological functions that protect against tumors metastasis. However, the effect FCGBP on HNSC unclear. pan-cancer tissues, expression survival status were analyzed using information from The Cancer Genome Atlas...
FOXP4-AS1 expression participates in multiple signal pathways and has been previously reported colorectal cancer, cervical other cancer cells. However, its role on prognosis immune infiltrates ovarian serous cystadenocarcinoma (OVs) remains unclear. The purpose of our study was to investigate the OVs association with infiltrates, determined prognostic roles OVs.Using Cancer Genome Atlas (TCGA) database, we retrieved clinical information for 376 patients OVs. Wilcoxon rank sum test used...
<title>Abstract</title> <bold>Background: </bold>The outbreak of COVID-19 in Wuhan quickly spread to 34 provinces, municipalities and autonomous regions the country 184 countries around world. It has drawn great attention from International Health Organization was declared an international public health emergency on January 31, 2020. Because population is generally susceptible virus, there are no effective drugs vaccines, active participation entire self-protection self-isolation become key...
Glioma is the most frequent malignant neoplasm of central nervous system with high recurrence and extremely poor prognosis. Hexokinase 2 (HK2) key enzyme in Warburg effect that has been proved to promote tumorigenesis found highly expressed several tumors. However, HK2 function glioma was reported only a few studies. In this review, we will summarize changes energy metabolism critical process. Further, recent research progress perspective diagnosis treatment be discussed.
Women with advanced-stage high-grade serous ovarian cancer (HGSOC) are likely to have a bad prognosis. Relapses common in patients even no evidence of disease after primary treatment. We aimed identify the prognostic factors for recurrence these patients.A nested case-control study was conducted large medical center Southwest China. The outcome within 3 years clinical remission (CR). Cox regression used calculate time event analysis different groups.Ninety-seven were finally included....