A5020178508- Neuroinflammation and Neurodegeneration Mechanisms
- Signaling Pathways in Disease
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Retinal Diseases and Treatments
- Ubiquitin and proteasome pathways
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Telomeres, Telomerase, and Senescence
- Phosphodiesterase function and regulation
- Mitochondrial Function and Pathology
- Ferroptosis and cancer prognosis
- Fatty Acid Research and Health
- Hydrogen's biological and therapeutic effects
- Neurological Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Genetic Syndromes and Imprinting
- Neuroblastoma Research and Treatments
- 14-3-3 protein interactions
- Neuropeptides and Animal Physiology
- Chromatin Remodeling and Cancer
Xi'an Medical University
2014-2025
Air Force Medical University
2015-2020
Shanghai Jiao Tong University
2010-2014
Temozolomide (TMZ) is the first-line chemotherapy drug that has been used to treat glioma for over a decade, but benefits are limited by half of treated patients who acquired resistance. Studies have shown TMZ resistance complex process with multiple factors, which not fully elucidated. Ferroptosis, new type cell death discovered in recent years, reported play an important role tumor The present study reviews relationship between ferroptosis and resistance, highlights Finally, investigators...
Ferroptosis is a newly discovered type of cell death decided by iron-dependent lipid peroxidation, but its role in glioblastoma remains unclear. Ibuprofen, nonsteroidal anti-inflammatory drug (NSAID), has been associated with antitumorigenic effects many cancers. In this study, we first found that ibuprofen inhibited the viabilities cells vitro and vivo, accompanied abnormal increase intracellular peroxidation. Further study showed growth inhibition caused could be rescued ferroptosis...
The ten‐eleven translocation (TET) family of methylcytosine dioxygenases catalyze oxidation 5‐methylcytosine (5mC) to 5‐hydroxymethylcytosine (5hmC) and promote DNA demethylation. Despite the abundance 5hmC TET proteins in brain, little is known about their role oligodendrocytes (OLs). Here, we analyzed expression during OL development vivo vitro , found that three members possess unique subcellular temporal patterns. Furthermore, level exhibits dynamic changes maturation, which implies...
DNA dioxygenases Ten-Eleven Translocation (TET) proteins can catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), and thereby alter epigenetic state DNA. The TET family includes TET1, TET2 TET3 members in mammals. Recently, accumulative research uncovered that TET1–3 occur abundantly central nervous system (CNS), their biological functions have just begun be investigated. In present study, we demonstrated mRNA protein were highly expressed cerebral cortex...
Glioblastoma multiforme (GBM; WHO grade IV) is one of the most common primary tumors central nervous system. This disease remains incurable human malignancies because molecular mechanism driving GBM development and recurrence still largely unknown. Here, we show that knockdown lymphocyte enhancer factor-1 (LEF1), a major transcription factor Wnt pathway, inhibits U251 cell migration, invasion, proliferation. Furthermore, downregulation LEF1 expression self-renewal capacity stem-like cells...
The inverse F-BAR (IF-BAR) domain proteins srGAP1, srGAP2 and srGAP3 are implicated in neuronal development may be linked to mental retardation, schizophrenia seizure. A partially overlapping expression pattern highly similar protein structures indicate a functional redundancy of srGAPs development. Our previous study suggests that negatively regulates differentiation Rac1-dependent manner mouse Neuro2a cells. Here we show exogenously expressed srGAP1 sufficient inhibit valporic acid...
Glioblastoma(GBM) is one of the most common and aggressive malignant primary tumors central nervous system mitochondria have been proposed to participate in GBM tumorigenesis. Previous studies identified a potential role Disrupted Schizophrenia 1 (DISC1), multi-compartmentalized protein, mitochondria. But whether DISC1 could regulate tumorigenesis via still unknown. We determined expression level by both bioinformatics analysis tissue analysis, found that was highly expressed GBM. Knocking...
Paired immunoglobulin-like receptor B (PirB), a functional for myelin-associated inhibitory proteins, plays an important role in axon regeneration injured brains. However, its normal brain function with age has not been previously investigated. Therefore this study, we examined the expression level of PirB cerebral cortex, hippocampus and cerebellum mice at 1 month, 3 months 18 age. The results showed that increased We further demonstrated overexpression inhibited neurite outgrowth PC12...
Summary Aims In acute stroke, neurological damage is due to oxidative stress and neuronal apoptotic death. This study investigated whether Nogo‐A 290‐562 residues region (M9), fused the transduction domain of HIV trans‐activator ( TAT ) protein, neuroprotective against cerebral ischemia mechanisms. Methods Transient focal was induced by middle artery occlusion in male C57 BL /6J mice. ‐M9, its mutation or vehicle applied via intraperitoneal injection at onset reperfusion. The neurobehavioral...