A5050265888- Alzheimer's disease research and treatments
- Neuropeptides and Animal Physiology
- Sleep and Wakefulness Research
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- Neuroendocrine regulation and behavior
- T-cell and B-cell Immunology
- Biochemical effects in animals
- Signaling Pathways in Disease
- Cholesterol and Lipid Metabolism
- Circular RNAs in diseases
- Mycobacterium research and diagnosis
- Smart Parking Systems Research
- Transportation Planning and Optimization
- Phosphodiesterase function and regulation
- Blood donation and transfusion practices
- Cancer Research and Treatments
- ATP Synthase and ATPases Research
Sichuan University
2023-2024
Xi'an Medical University
2016-2023
Lanzhou University
2010-2016
MicroRNAs (miRNAs or miRs) play crucial roles in human breast cancer. Although miR-1254 has been shown to have oncogenic activity several cancer types, its biological function and mechanisms of action remain unclear. In this study, we investigated the role sought elucidate relevant underlying mechanisms. We found that expression was markedly increased tissues cell lines. Additionally, overexpression accelerated proliferation, cycle G1-S phase transition inhibited apoptosis. Nevertheless,...
Paired immunoglobulin-like receptor B (PirB), a functional for myelin-associated inhibitory proteins, plays an important role in axon regeneration injured brains. However, its normal brain function with age has not been previously investigated. Therefore this study, we examined the expression level of PirB cerebral cortex, hippocampus and cerebellum mice at 1 month, 3 months 18 age. The results showed that increased We further demonstrated overexpression inhibited neurite outgrowth PC12...
Immunotherapy with transplanted T‑regulatory (Treg) cells is currently in use. However, patients have complex internal environments confounding factors, including the presence of inflammatory cytokines. The present study aimed to detect Treg cell function under simulated conditions provide a foundation for cell‑based immunotherapy. CD4+CD25high were sorted from peripheral blood mononuclear and cultured 14 days recombinant human interleukin‑2 (rhIL‑2) anti‑CD3/CD28 beads, or without 25 ng/ml...
BACKGROUND: Immunosuppressive receptor LILRB1 regulates tumors progression by transducing immune inhibitory signals via intracellular immunoreceptor tyrosine-based motifs. However, its role in Hepatocellular Carcinoma (HCC) remains vague. OBJECTIVE: This study is aimed to disclose the as sociation between and HCC. METHODS: Immunoblotting qRT-PCR were employed evaluate level of hepatocarcinoma cells. LILRB1-positive cells tissue array measured using immunohistochemistry staining. The relation...
Mitochondrial fission depends on dynamin-related protein 1 (Drp1) guanosine triphosphatase activity. Although there is some association between Drp1 and gastric cancer, the detailed mechanism remains largely unknown. In this study, elevation of was observed in human carcinoma specimens including mixed adenocarcinoma tissues, intestinal-type cancer cells compared to normal control, but not diffuse tissues. Gastric patients with high harbored advanced pathological stages poor progression-free...