A5101470573- Neuropeptides and Animal Physiology
- Sleep and Wakefulness Research
- Hypothalamic control of reproductive hormones
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Pain Mechanisms and Treatments
- X-ray Diffraction in Crystallography
- Immune Response and Inflammation
- Heat Transfer and Optimization
- Biomimetic flight and propulsion mechanisms
- Computational Fluid Dynamics and Aerodynamics
- Fluid Dynamics and Turbulent Flows
- Engineering Applied Research
- Neuroendocrine regulation and behavior
- Automotive and Human Injury Biomechanics
- Polydiacetylene-based materials and applications
- Refrigeration and Air Conditioning Technologies
- Immune responses and vaccinations
- Biochemical effects in animals
- Tryptophan and brain disorders
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- Respiratory Support and Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Risk and Safety Analysis
Lanzhou University
2005-2024
Northwestern Polytechnical University
2021-2023
Lanzhou City University
2021
Extra-motor symptoms are increasingly recognised in amyotrophic lateral sclerosis (ALS), encompassing cognitive, social, and behavioural deficits that can substantially impact quality of life. TAR DNA binding protein 43 (TDP-43) pathology is the central disease marker almost all cases ALS approximately half frontotemporal dementia (FTD). However, mechanisms linking TDP-43 with extra-motor TDP-43-associated neurodegenerative diseases remain unresolved. In this study, we used rNLS8 mouse...
The aerodynamic forces and flowfield on a delta-wing Unmanned Aerial Vehicle (UAV) with specific airfoil are studied here. leading-edge protuberances inspired from the flippers of humpback whale is introduced in present work to watch its effect stall delaying drag reduction. Two installing factors, which amplitude wavelength protuberances, considered study interaction variation de-tached vortex. Three changes both investigated herein. Generally, modified models have larger angle attack than...
The purpose of this study was to investigate the effects [Nphe1]nociceptin(1-13)-NH2 on nociceptin-induced decreases in mean arterial pressure (MAP), heart rate (HR), and hindquarters vascular bed resistance (HVBR) anesthetized rat. results showed that i.c.v. or i.v. (1.5-12 nmol/kg 5-120 nmol/kg, respectively) could antagonize depressor nociceptin (3 30 MAP HR. Furthermore, (5-120 nmol/kg) reverse (30 nmol/kg)-induced decrease HVBR. However, had no significant similar induced by morphine....
We successfully incorporated fatty acids into neuropeptide S to produce a novel self-assembling biomaterial that demonstrates enhanced nose-to-brain penetration and exerts prolonged anxiolytic-like effect.
Multidrug resistance against conventional antibiotics has dramatically increased the difficulty of treatment and accelerated need for novel antibacterial agents. The peptide Tat (47–57) is derived from transactivating transcriptional activator human immunodeficiency virus 1, which well-known as a cell-penetrating in mammalian cells. However, it also reported that antifungal activity. In this study, series membrane-active hydrocarbon-stapled α-helical amphiphilic peptides were synthesized...
Aberrant canonical NF-κB signaling has been implicated in diseases, such as autoimmune disorders and cancer. Direct disruption of the interaction NEMO IKKα/β developed a novel way to inhibit overactivation NF-κB. Peptides are potential solution for disrupting protein-protein interactions (PPIs); however, they typically suffer from poor stability