A5082439649- Extracellular vesicles in disease
- NF-κB Signaling Pathways
- Helicobacter pylori-related gastroenterology studies
- GDF15 and Related Biomarkers
- Intensive Care Unit Cognitive Disorders
- Inflammatory Bowel Disease
- Respiratory Support and Mechanisms
- Neuropeptides and Animal Physiology
- Microscopic Colitis
- Biochemical Analysis and Sensing Techniques
- Anesthesia and Neurotoxicity Research
- Regulation of Appetite and Obesity
- Neuroinflammation and Neurodegeneration Mechanisms
- Circular RNAs in diseases
- Climate Change and Health Impacts
- Thermoregulation and physiological responses
- Barrier Structure and Function Studies
- Immune Response and Inflammation
- Graphene and Nanomaterials Applications
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- S100 Proteins and Annexins
Lanzhou University
2018-2024
Changhai Hospital
2023-2024
Second Military Medical University
2023-2024
Central Hospital of Wuhan
2023
General Hospital of Central Theater Command
2023
MOTS-c is a 16-amino acid mitochondrial derivative peptide reported to be involved in regulating insulin and metabolic homeostasis via the AMP activated protein kinase (AMPK). AMPK agonist AICAR has been improve cognition. Previous reports also pointed out that may effective as therapeutic option toward prevention of aging processes. Therefore, we investigated roles memory recognition process. The results showed central not only enhanced object location formation consolidation but...
Endothelial barrier disruption plays a key role in the pathophysiology of heat stroke (HS). Knockout DNAJA1 (DNAJA1‑KO) is thought to be protective against HS based on genome‑wide CRISPR‑Cas9 screen experiment. The present study aimed illustrate function DNAJA1‑KO human umbilical vein endothelial cells. cells were infected using lentivirus investigate HS‑induced disruption. It was shown that could ameliorate decreased cell viability and increased injury, according results Cell Counting Kit‑8...
Background Accumulating evidence suggests that inhibiting neuroinflammation as a potential target in therapeutic or preventive strategies for Alzheimer's disease (AD). MAPK-activated protein kinase II (MK2), downstream of p38 mitogen activated (MAPK) MAPK, was unveiled promising option the treatment AD. Increasing points at MK2 involved neuroinflammatory responses. MMI-0100, cell-penetrating peptide inhibitor MK2, exhibits anti-inflammatory effects, and is current clinical trials pulmonary...
Backgrounds: This study aimed to investigate the protective effects of MMI-0100, a cell-penetrating peptide inhibitor MAPK-activated protein kinase II (MK2), on acute colitis induced by dextran sodium sulfate (DSS). Mice were injected intraperitoneally with different doses MMI-0100 (0.5 and 1 mg/kg per day, six days). The physiological indexes, parameters for colonic pathological injury intensity inflammatory responses evaluated histological staining, quantitative PCR, western blotting,...
Cortistatin-14 (CST-14), a recently discovered cyclic neuropeptide, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor exert its biological activities co-exists with GABA within the cortex hippocampus. However, role of CST-14 in control depression processes is not still clarified. Here, we tested behavioral effects variety classical rodent models (forced swimming test, tail suspension test novelty-suppressed feeding test). In depression, produced...
Aberrant canonical NF-κB signaling has been implicated in diseases, such as autoimmune disorders and cancer. Direct disruption of the interaction NEMO IKKα/β developed a novel way to inhibit overactivation NF-κB. Peptides are potential solution for disrupting protein-protein interactions (PPIs); however, they typically suffer from poor stability
Abstract Background: MOTS-c is a 16-amino acid mitochondrial derivative peptide reported to be involved in regulating insulin resistance and obesity, osteoporosis inflammatory responses. Accumulating evidences suggest that inhibiting neuroinflammation potential target therapeutic or preventive strategies for Alzheimer’s disease (AD). Due the widespread distribution of MOTS CNS its role metabolism immune system, previous reports also pointed out may effective as option toward prevention aging...
Abstract Background & Aim: Exosomes are effective mediators of cell-to-cell interactions and carry many regulatory molecules, including miRNAs, that can play crucial roles in diverse fundamental biological processes. However, to date, no study has reported macrophage exosomal involvement the development inflammatory bowel disease (IBD). This investigated specific miRNAs macrophage-derived exosomes IBD potential molecular mechanism. Methods: Dextran sulfate sodium (DSS) was used generate...