A5018490385- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Extracellular vesicles in disease
- Pediatric Hepatobiliary Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Gut microbiota and health
- AI in cancer detection
- Diverticular Disease and Complications
- Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Mycobacterium research and diagnosis
- Gastroesophageal reflux and treatments
- COVID-19 Clinical Research Studies
- Cleft Lip and Palate Research
- Esophageal Cancer Research and Treatment
- Inflammatory Bowel Disease
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Gastrointestinal disorders and treatments
- Autophagy in Disease and Therapy
First Hospital of Lanzhou University
2023-2025
Second Military Medical University
2001-2024
Changhai Hospital
2016-2024
National Clinical Research Center for Digestive Diseases
2019-2024
State Council of the People's Republic of China
2020-2023
First Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
Ruijin Hospital
2023
Shanghai Jiao Tong University
2023
Lanzhou University
2023
Psychosocial stress is a critical inducing factor of inflammatory bowel diseases (IBD), while autophagy novel central issue IBD development. The present study investigated the potential role in stress-related patients and animal model. correlation between psychosocial intestinal was determined 23 with IBD. Corticotropin-releasing hormone (CRH), well-established inducer stress, administrated dextran sulfate sodium (DSS)-induced mice lipopolysaccharide (LPS)-stimulated bone marrow-derived...
Abstract Background and study aims Ideal bowel preparation for colonoscopy requires complete removal of fluid foam from the colon. Polyethylene glycol (PEG) is widely used preparation, with antifoaming agents such as simethicone commonly in combination PEG. Data on effect adenoma detection rate (ADR) were limited. This therefore aimed to investigate whether preprocedure could increase ADR. Patients methods was a prospective, multicenter, endoscopist-blinded randomized controlled trial...
Objective Adequate bowel preparation is essential for a successful colonoscopy; clinical studies suggest reinforced education can improve the process. However, there have been no trials to compare WeChat directions (the most widely used social media app in China) with those of short message service (SMS). This study was aimed assess effect and SMS on quality. Participants methods single-center, prospective, endoscopically blinded, randomized, controlled study. Patients groups received...
Abstract We report a rare case of severe acute pancreatitis with hypercalcaemia induced by primary hyperparathyroidism (PHPT) in 27-year-old female patient at 28 weeks gestation during pregnancy. The initially presented onset epigastric pain nausea and vomiting was diagnosed pancreatitis, hypercalcaemia, PHPT. After conservative management, the underwent caesarean section successfully delivered baby boy, who suffered from hypocalcaemic convulsions postnatal period. patient’s blood calcium...
INTRODUCTION: Although the 9-minute mean withdrawal time (m-WT) is often reported to be associated with optimal adenoma detection rate (ADR), no randomized trials of screening colonoscopy have confirmed impact a m-WT on miss (AMR) and ADR. METHODS: A multicenter tandem trial was conducted in 11 centers. Seven hundred thirty-three asymptomatic participants were receive segmental withdrawal, followed by 6-minute (9-minute-first group, 9MF, n = 366) or vice versa (6-minute-first 6MF, 367). The...
Objective: Current study aims to investigate whether serum exosomal microRNAs (miRNAs) could be potential biomarkers in predicting APs with POF at early phase. Background: Novel are sorely needed for prediction of persistent organ failure (POF) acute pancreatitis (AP) patients. Methods: In the discovery stage, miRNAs were profiled sera from or without (5 vs. 5) using microarrays. POF-associated miRNA signatures then assessed training cohort (n=227) and further validated three independent...
Abstract Background and Aim Endoscopic transmural drainage has been recognized as the first‐line treatment for pancreatic fluid collection (PFC). Currently, three different types of stents have extensively applied, including double pigtail plastic stent (PS), fully covered self‐expanding metal (FCSEMS), novel lumen‐apposing (LAMS). Nonetheless, limited data are available about comparison among them in terms their clinical outcomes safety endoscopic ultrasound‐guided PFC. Methods The current...
Abstract Psychosocial stress is a vital factor contributing to the pathogenesis and progression of inflammatory bowel disease (IBD). The contribution intestinal macrophage autophagy onset development IBD has been widely studied. Herein, we investigated underlying mechanism psychosocial in an mouse model pertaining autophagy. Corticotropin releasing hormone (CRH) was peripherally administrated induce stress. For vivo studies, dextran sulfate sodium (DSS) used for creation our model. vitro...
Colon cancer is one of the most frequent malignancies and causes high mortality worldwide. Exploring tumor-immune interactions in tumor microenvironment identifying new prognostic therapeutic biomarkers will assist decoding novel mechanism immunotherapy. BGN a typical extracellular matrix protein that was previously validated as signaling molecule regulating multiple processes tumorigenesis. However, its role immunity requires further investigation. The differentially expressed genes three...
Artificial intelligence in colonoscopy is an emerging field, and its application may help colonoscopists improve inspection quality reduce the rate of missed polyps adenomas. Several deep learning-based computer-assisted detection (CADe) techniques were established from small single-center datasets, unrepresentative learning materials might confine their generalization wide practice. Although CADes have been reported to identify colonoscopic images videos real time, diagnostic performance...
Abstract Background and Aim Endoscopic retrograde cholangiopancreatography (ERCP) is associated with risk of complications. Methods to facilitate ductal cannulation may reduce Intraduodenal acid infusion a physiological approach stimulate secretin release in human body cannulation. The objective this study was investigate the effect intraduodenal on pancreatic duct during ERCP. It single center, double‐blind, randomized controlled trial. Consecutive patients undergoing first ERCP for...