A5103136035- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Gastroesophageal reflux and treatments
- Cancer-related gene regulation
- Intestinal Malrotation and Obstruction Disorders
- Ovarian function and disorders
- Sexual function and dysfunction studies
- Pathogenesis and Treatment of Hiccups
- Macrophage Migration Inhibitory Factor
- Reproductive Biology and Fertility
- Spaceflight effects on biology
- DNA Repair Mechanisms
- Genetic Associations and Epidemiology
- Biliary and Gastrointestinal Fistulas
First Affiliated Hospital of Dalian Medical University
2006-2025
Dalian Medical University
2007-2025
University of Washington
2020
First Hospital of Lanzhou University
2004
Lanzhou University
2004
ABSTRACT Background Altered glucose metabolism is a critical characteristic from the beginning stage of esophageal squamous cell carcinoma (ESCC), and phenomenon presented as pink‐color sign under endoscopy after iodine staining. Therefore, calculating metabolic score based on gene sets may bring some novel insights, enabling prediction prognosis identification treatment choices for ESCC. Methods A total 8, 99, 140 individuals The Gene Expression Omnibus database, Cancer Genome Atlas...
INTRODUCTION: Although the 9-minute mean withdrawal time (m-WT) is often reported to be associated with optimal adenoma detection rate (ADR), no randomized trials of screening colonoscopy have confirmed impact a m-WT on miss (AMR) and ADR. METHODS: A multicenter tandem trial was conducted in 11 centers. Seven hundred thirty-three asymptomatic participants were receive segmental withdrawal, followed by 6-minute (9-minute-first group, 9MF, n = 366) or vice versa (6-minute-first 6MF, 367). The...
Background The Charlson Comorbidity Index (CCI) and prognostic nutritional index (PNI) have proven to be valuable tools in predicting prognosis based on comorbidities status the context of surgical procedures endoscopic resections. age-Adjusted CCI (ACCI) has also shown utility settings, but its application early gastric cancer (EGC) remains unexplored. Consequently, we aimed at clarifying factors for EGC treated with submucosal dissection (ESD).
Esophageal squamous cell carcinoma (ESCC) represents a frequent cancer with poor prognosis. Altered glucose metabolism contributes factor to ESCC progression. In our previous study, signal sequence receptor subunit delta (SSR4) was included in an prognostic model; however, the mechanisms underlying SSR4 implication remain ambiguous. Accordingly, we aim determine interconnection between expression and clinical characteristics of ESCC. This differential significance performed using bulk...
In patients with early gastric cancer (EGC) who undergo endoscopic submucosal dissection (ESD) curability (eCura) C-2, the risk of non-gastric mortality should be evaluated before receiving further gastrectomy. Charlson comorbidity index (CCI) is often used to estimate prognosis based on patient's background treatment. We identified long-term from other causes associated comorbidities in CCI and applied it creation EGC specific (GCCI). A total 1810 3 centers were included January 2015...
Background: Despite its extensive utilization in Chinese hospitals for treating acute pancreatitis (AP) and related respiratory distress syndrome (ARDS), the active components mechanisms underlying action of Qingyi Granule (QYKL) remain elusive. Methods: This study consists four parts. First, we used Mendelian randomization (MR) to investigate causal relationship between AP, cytokine, ARDS. Next, 321 patients were collected evaluate efficacy QYKL combined with dexamethasone (DEX) AP. In...
Several hereditary syndromes characterized by defective DNA repair are associated with high risk of colorectal cancer (CRC). To explore whether common polymorphisms in genes affect and prognosis CRC, we evaluated the association between single nucleotide (SNPs) XPG, XPC, WRN gene susceptibility clinical outcomes a population-based case-control study. A total 890 CRC cases 910 controls recruited into study provided biologic sample. Individuals variant genotypes XPC Ala499Val appeared to be...
Approximately 10% to 40% of patients with gastroesophageal reflux disease (GERD) exhibit poor response proton pump inhibitors (PPIs), indicating refractory GERD (RGERD). Banxia Houpu Decoction is a traditional Chinese medicine formula used for treating GERD, particularly atypical symptoms. This study aimed investigate the improvement different symptoms in RGERD treated and identify relevant factors influencing its efficacy. From November 2021 2022, total 89 voluntarily participated this...
Few studies showed that mixed type early gastric cancer (EGC) relates to higher risk of lymph node metastasis. We aimed explore the clinicopathological feature GC according different proportions undifferentiated components (PUC) and develop a nomogram predict status metastasis (LNM) in EGC lesions.Clinicopathological data 4,375 patients who underwent surgically resection for our center were retrospectively evaluated finally 626 cases included. classified lesions into five groups (M1:0% < PUC...
Early-stage gastroesophageal junction (GEJ) adenocarcinoma can be challenging to diagnose and treat promptly using endoscopy. This study aims summarize the endoscopic characteristics of early GEJ investigate their correlation with pathological grade invasion depth.
Background Polycystic ovary syndrome (PCOS) is defined by oligo/anovulation, hyperandrogenism, and polycystic ovaries with uncertain pathogenesis. The proteome represents a substantial source of therapeutic targets, their coding genes may elucidate the mechanisms underlying PCOS. However, reports on profiles human plasma protein-coding PCOS are limited. Here, we aimed to investigate novel biomarkers or drug targets for integrating genetics proteome. Methods Our study acquired protein...
Multiple colorectal cancers are extremely rare, few cases can be searched in the literature. Our group only found 6 published. We report a case where 3 diseases coexisted summarize currently available A 75-year-old man presented with changes his bowel habits and hematochezia. After colonoscopy biopsies community hospital, he was diagnosed descending adenocarcinoma patient. To get further treatment, came to our hospital. Colonoscopy revealed ulcerative lesions colon, 2 polypoid sigmoid...