A5091075355- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Hemoglobinopathies and Related Disorders
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- Erythrocyte Function and Pathophysiology
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Chemokine receptors and signaling
- Cytokine Signaling Pathways and Interactions
- PARP inhibition in cancer therapy
- Melanoma and MAPK Pathways
- vaccines and immunoinformatics approaches
- Inflammasome and immune disorders
- Gene expression and cancer classification
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
Liuzhou Maternal and Child Health Hospital
2020-2025
Fujian Provincial Cancer Hospital
2019-2025
Fujian Medical University
2019-2025
Tongji University
2023-2025
Xiamen University
2025
Guangzhou Women and Children Medical Center
2025
Guangxi Medical University
2024
Shanghai Tenth People's Hospital
2024
First Affiliated Hospital of GuangXi Medical University
2024
China Medical University
2019
Neoantigens are ideal targets for dendritic cell (DC) vaccines. So far, only a few neoantigen-based DC vaccines have been investigated in clinical trials. Here, we reported case of patient with metastatic gastric cancer who received personalized neoantigen-loaded monocyte-derived (Neo-MoDC) followed by combination therapy the Neo-MoDC and immune checkpoint inhibitor (ICI). The developed T responses against neoantigens after receiving vaccine alone. following triggered stronger response...
<h3>Importance</h3> Immune checkpoint inhibitors (ICIs) can elicit durable antitumor responses in patients with non–small cell lung cancer (NSCLC), but only 20% to 25% of respond treatment. As important genes the DNA damage response pathway, comutation tumor protein p53 (<i>TP53</i>) and ataxia-telangiectasia mutated (<i>ATM</i>) may be associated genomic instability hypermutation. However, prevalence of<i>TP53</i>and<i>ATM</i>comutation its association ICIs are not fully understood....
Abstract The immunomodulatory effect of the interferon gene‐stimulating factor (STING) pathway makes it an important target for tumor immunotherapy, which, however, suffers from easy degradation and deteriorated stimulatory capacity current STING agonists in solid microenvironment. Herein, a nanocomposite medicine， MLAP， is constructed by intercalating agonist ADU‐S100 into Mn‐doped layered double hydroxide, which capable modulating immune microenvironment tumors to enhance activation....
Adenylate kinase (AK), also referred to as adenosine triphosphate-adenosine monophosphate phosphotransferase, serves an essential function in regulating cellular energy metabolism. A deficiency red blood cell adenylate 1 (AK-1) is linked congenital non-spherocytic hemolytic anemia well delays both mental and psychomotor development. This extremely rare autosomal recessive genetic disorder, with 13 highly pathogenic variants of the AK-1 gene documented globally through testing. Thalassemia, a...
Combining radiotherapy (RT) with immunotherapy for head and neck squamous cell carcinoma (HNSCC) has limited effectiveness due to the DNA damage repair (DDR) pathway activated by ionizing radiation. DNA-PK, encoded PRKDC gene, plays a key role in this repair. The potential improvement of radioimmunotherapy inhibiting DDR is still unclear. different treatments on tumor growth survival was tested using C3H/HeN mouse model. Flow cytometry analyzed treatment-induced immunophenotypic changes. In...
This study investigated hemoglobin (Hb) variant prevalence and molecular characteristics in Laibin City, Central Guangxi, China. Using capillary electrophoresis (CE), 33,958 individuals from six regions within area were screened, with hematological parameters analyzed via automated cell counters. Gap-PCR/RDB-PCR identified common α/β-thalassemia mutations, while Sanger sequencing characterized Hb variants. Single-molecule real-time (SMRT) was performed to identify breakpoints a sample large...
Abstract Background SETD2 protects against genomic instability via maintenance of homologous recombination repair (HRR) and mismatch (MMR) in neoplastic cells. However, it remains unclear whether dysfunction is a complementary or independent factor to microsatellite instability-high (MSI-H) tumor mutational burden-high (TMB-H) for immunocheckpoint inhibitor (ICI) treatment, little known regarding this type acts differently various types cancer. Methods This cohort study used multidimensional...
To investigate the clinicopathological and prognostic factors related to early gastric cancer recurrence after curative resection.Between October 2006 August 2018, a total of 149 patients with cancer/adenocarcinoma esophagogastric junction resection were enrolled from our treatment group. A retrospective clinical analysis was performed on these resection.Among patients, 99 (66.4%) had only one pattern, 50 (33.6%) multiple patterns. The median recurrence-free survival (RFS) 18.2 months (95%...
Immunogenic cell death (ICD) is a type of regulated that can activate adaptive immune response, and its ability to reshape the tumor microenvironment via multiple mechanisms may contribute immunotherapy. The treatment options for patients with skin cutaneous melanoma (SKCM) vary based on BRAF V600E statuses. However, all standard treatments include Therefore, it critical identify ICD‐associated signatures help classify according benefits from ICD In this study, data samples mutation (BRAF...
Artificial intelligence in colonoscopy is an emerging field, and its application may help colonoscopists improve inspection quality reduce the rate of missed polyps adenomas. Several deep learning-based computer-assisted detection (CADe) techniques were established from small single-center datasets, unrepresentative learning materials might confine their generalization wide practice. Although CADes have been reported to identify colonoscopic images videos real time, diagnostic performance...
We analyzed hemoglobin (Hb) levels and degree of anemia in relation to genotype patients with H (Hb H) disease, thereby providing a scientific basis for the prevention treatment Hb disease Guangxi region China. analysis was conducted 615 using high performance liquid chromatography. Seven α-thalassemia 17 β-thalassemia genotypes commonly found Chinese population were detected by Gap-polymerase chain reaction reverse dot hybridization. Multiple ligation-dependent probe amplification...
Long noncoding RNAs (lncRNAs) regulate cancer cell senescence in many cancers. However, their specific involvement head and neck squamous carcinoma (HNSCC) remains unclear. We are looking for an ingenious prognostic signature that utilizes senescence-related lncRNAs (SRlncRNAs) to predict prognosis provide insights into the immune landscape HNSCC.
Our previous study found that plate factor-4 variant (CXCL4L1) was downregulated in the serum of patients with prostate cancer (PCa). The aim present to investigate prognostic value CXCL4L1 PCa. In total, 213 PCa treated radical prostatectomy were enrolled and peripheral blood samples all collected. Expression different tumor stages grades measured by enzyme-linked immunosorbent assay (ELISA). Kaplan–Meier method applied estimate progression castration-resistant (CRPC), metastasis,...
Chromobox protein homolog 8 (CBX8), a transcriptional repressor, participates in many biological processes various carcinomas. Cell differentiation, aging, and cell cycle progression are examples of such processes. It is critical to investigate CBX8 expression its relationship with clinicopathological characteristics liver hepatocellular carcinoma (LIHC), kidney renal clear (KIRC), ovarian cancer (OV) CBX8's potential diagnostic prognostic values. TCGA CPTAC databases were used compare the...
To perform molecular diagnosis and pedigree analysis for one case with α-thalassemia who does not conform to the genetic laws, explore effects of a newly discovered rare mutation (
With the qualitative analysis method, paper uses three types of generative AI such as ChatGPT, Claude2, and ERNIE Bot to translate chemical text, aiming conclude common errors committed by during E-C translation text provide some countermeasures. The findings show that include five aspects: terminological aspect, lexical syntactic discourse format aspect. Based on these errors, proposes following countermeasures: (1) Translators can obtain accurate terminology utilizing “Method Suspicion,...
Abstract Advances in adaptive immunity have greatly contributed to the development of cancer immunotherapy. However, its over‐low efficacy and insufficient invasion immune cells tumor tissue, safety problems caused by cytokine storm, seriously impeded further clinical application for solid Notably, microenvironment lungs is naturally enriched with alveolar macrophages (AMs). Herein, we introduce a novel nebulized magnetothermal immunotherapy strategy treat orthotopic lung using nanomaterial...
Advances in adaptive immunity have greatly contributed to the development of cancer immunotherapy. However, its over-low efficacy and insufficient invasion immune cells tumor tissue, safety problems caused by cytokine storm, seriously impeded further clinical application for solid Notably, microenvironment lungs is naturally enriched with alveolar macrophages (AMs). Herein, we introduce a novel nebulized magnetothermal immunotherapy strategy treat orthotopic lung using nanomaterial (Zn-CoFe
The precise mechanism of atrial fibrillation (AF) remains uncertain but suggested to be correlated with pathogenic infection. This study sought determine the role viral pathogens, herpes simplex virus (HSV)-1, HSV-2, and cytomegalovirus (CMV), in AF recurrence after radiofrequency catheter ablation a strictly selected patient population. A total 4148 patients undergoing were screened for structural heart diseases known risk factors AF, resultant 103 (74 paroxysmal 29 persistent) recruited....
The innate immune system plays a critical role in the host response against pathogenic microbial infection. However, aberrant activation of pathways is characteristic feature various diseases. Thus, targeted drugs must be developed based on understanding signaling pathways. This study demonstrated that an allene small molecule (DWL-4-140) can efficiently and selectively exert regulatory effects stimulator interferon genes (STING), resulting downregulation DNA-induced responses....
e16578 Background: Previous data has shown that a positive response to immunotherapy usually relies on active interactions between tumor cells and immunomodulators inside the microenvironment (TME). The aim of this study was classify gastric cancer (GC) subsets based TME immune status according expression PD-L1 infiltration CD8+ T cells. Methods: One hundred eighty-six tissue from patients with curative D2 gastrectomy were examined for evaluating using histopathologic analysis. molecular...
OBJECTIVE To perform dried blood spots thalassemia gene detection in patients with positive phenotypes by microarray technology, and evaluate its value clinical detection. METHODS DNA samples were extracted from of 410 patients. Microarray technology was used to detect 3 deletion non-deletion types α-thalassemia 19 β-thalassemia point mutations which common mutions China. RESULTS There 357 cases all the tested rate 87.07%, among 299 (72.93%) carried or α-thalassemia, 29 (7.07%) complex...