A5100430874- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- Mesenchymal stem cell research
- Corneal surgery and disorders
- Pluripotent Stem Cells Research
- Maternal and fetal healthcare
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Chronic Myeloid Leukemia Treatments
- Ocular Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Tissue Engineering and Regenerative Medicine
- RNA modifications and cancer
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
- Vascular Malformations Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Lymphoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
Peking Union Medical College Hospital
2012-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2025
Capital Medical University
2025
Tianjin Medical University
2023-2025
Army Medical University
2011-2024
Xinqiao Hospital
2011-2024
Hunan Children's Hospital
2024
Xijing Hospital
2024
Sun Yat-sen University
2023
Sun Yat-sen University Cancer Center
2023
Inflammation is a common medical complication in colorectal cancer (CRC) patients, which plays significant roles tumor progression and immunosuppression. However, the influence of inflammatory conditions on response to immune checkpoint inhibitors (ICI) incompletely understood. Here we show that patient with high microsatellite instability (MSI-H) CRC local condition, primary progresses but its liver metastasis regresses upon Pembrolizumab treatment. In silico investigation prompted by this...
Abstract Background Mesenchymal stem/stromal cells (MSCs) are multipotent with a promising application potential in regenerative medicine and immunomodulation. However, MSCs cultured vitro exhibit functional heterogeneity. The underlying molecular mechanisms that define MSC heterogeneity remain unclear. Methods We investigated the gene expression profile via single-cell RNA sequencing (scRNA-seq) of human primary Wharton’s jelly-derived (WJMSCs) from three donors. also isolated CD142 + −...
Neoantigens are ideal targets for dendritic cell (DC) vaccines. So far, only a few neoantigen-based DC vaccines have been investigated in clinical trials. Here, we reported case of patient with metastatic gastric cancer who received personalized neoantigen-loaded monocyte-derived (Neo-MoDC) followed by combination therapy the Neo-MoDC and immune checkpoint inhibitor (ICI). The developed T responses against neoantigens after receiving vaccine alone. following triggered stronger response...
Low temperature can affect the growth and development of plants through changes in DNA demethylation patterns. Another known effect low is accumulation anthocyanin pigments. However, it not whether two phenomena are linked, specifically, participates response to low-temperature stress. The ROS1 gene involved plant influences methylation levels In this study, using RNA sequencing, we detected that transcription MdROS1 correlate with content, as well those biosynthesis-related genes apple...
Abstract Genome-wide association study (GWAS) has seen great strides in revealing initial insights into the genetic architecture of Parkinson’s disease (PD). Since GWAS signals often reside non-coding regions, relatively few associations have implicated specific biological mechanisms. Here, we aimed to integrate results with large-scale expression quantitative trait loci (eQTL) 13 brain tissues identify candidate causal genes for PD. We conducted a transcriptome-wide (TWAS) PD using summary...
Anthocyanins are secondary metabolites in land plants that contribute to the colors of leaves and flowers, nutritionally valuable components human diet. The DFR gene plays an important role anthocyanin biosynthetic pathway. In this study, we investigated regulation expression different Malus crabapple cultivars show distinct patterns leaf coloration, how it influences accumulation coloration. Specifically, studied ever-red leaved cultivar ‘Royalty’, ever-green ‘Flame’ spring-red ‘Radiant’....
Abstract The euchromatin histone methyltransferase 2 (also known as G9a) methylates H3K9 to repress gene expression, but it also acts a coactivator for some nuclear receptors. molecular mechanisms underlying this activation remain elusive. Here we show that G9a functions of the endogenous oestrogen receptor α (ERα) in breast cancer cells methylation-independent manner. dimethylates ERα at K235 both vitro and cells. Dimethylation ERαK235 is recognized by Tudor domain PHF20, which recruits MOF...
Hepatic stellate cells (HSCs) play a central role in the development of liver fibrosis, and their activation is controlled by complex interplay autocrine/paracrine signals within microenvironment. Here, we show that growth differentiation factor 10 (GDF10) specifically expressed HSCs both mouse human livers, its expression reduced activated HSCs. Loss GDF10 function promotes HSC exacerbates fibrosis mice, while gain alleviates this pathological condition. Mechanistically, autocrine binds to...
BACKGROUND: Analyses of genomic and proteomics data in prospective biobank studies diverse populations may discover novel or repurposing drug targets for stroke. METHODS: We extracted individual cis -protein quantitative trait locus 2923 proteins measured using Olink Explore panel from a genome-wide association study China Kadoorie Biobank UK Biobank, both established ≈20 years ago. These loci were used ancestry-specific 2-sample Mendelian randomization analyses ischemic stroke (IS) East...
Background The combination of cyclin-dependent kinases 4 and 6 inhibitors (CDK4/6i) with endocrine therapy (ET) has emerged as an effective alternative to neoadjuvant chemotherapy (NCT) for patients hormone receptor-positive (HR+) human epidermal growth factor receptor 2 (HER2) -negative breast cancer (BC). This single-center study retrospectively evaluated the efficacy safety dalpiciclib combined aromatase inhibitor (AI) compared NCT. Methods clinicopathological data treatment details HR+...
Background and Objective: Vitamin D‐binding protein (DBP) is a multifunctional highly expressed plasma protein. Among its diverse roles, including those in the immune inflammatory responses, it primary carrier of vitamin D, which has been implicated periodontitis. We hypothesized that there correlation between systemic DBP levels generalized aggressive periodontitis (GAgP). Material Methods: Forty‐four patients with GAgP 32 healthy controls were recruited. Clinical parameters examined, mean...
Acute lung injury (ALI) is a serious complication that may accompany severe pneumonia in children. Derived from human umbilical cord mesenchymal stem cell exosome (HucMSC-Exo) can contribute to the regeneration of damaged tissue. This study aims investigate impact HucMSC-Exo on ALI and its potential mechanisms.
Animal models are crucial for elucidating the pathological mechanisms underlying Parkinson's disease (PD). Unfortunately, most of transgenic mouse fail to manifest changes observed in PD patients, pending advancement research. However, mechanism this discrepancy remains elusive. Here, we provide compelling evidence that compensatory expression synaptotagmin-11 (Syt11) plays a key role concealing PD-associated phenotypes parkin knockout (KO) models. Unlike normal dopamine (DA) release and...
Objective: To analyze the types and characteristics of post-operative complications in colorectal cancer patients aged over 85 years undergoing laparoscopic surgery, to summarize peri-operative management strategies. Methods: This was an observational study. Inclusion criteria: pathologically confirmed adenocarcinoma; tumor located ileocecum, ascending colon, transverse descending sigmoid or rectum; radical resection for cancer; complete clinical data. Exclusion criteria included distant...
purpose. To evaluate the safety and efficacy of dispase plasmin when inducing posterior vitreous detachment (PVD) by intravitreous injection in rabbit eyes. methods. Forty-eight young pigmented rabbits were randomized into six groups. Groups 1 5 received 0.025 U test eyes; group 2, 0.1 dispase; groups 3 6, plasmin; 4, 4 plasmin. All PBS control 6 euthanatized 15 minutes after surgery for ocular histologic examination. The remaining (groups 1–4) indirect ophthalmoscope biomicroscopy 30...
Background To determine the prevalence and risk factors associated with idiopathic epiretinal membranes (iERM) in a Chinese population aged 60 years or older Beixinjing Blocks, Shanghai. Methods This population-based study consisted of 3727 participants (89.7% eligible). It was performed to describe iERM possible demographic, systemic, ocular iERM. Each participant underwent standardized interview comprehensive ophthalmic examination. identified graded from retinal photographs. Then,...
Background and Objective Calprotectin (S100A8/A9) is a heterodimer of S100A8 S100A9 associated with multiple inflammatory diseases, including Crohn's disease, rheumatoid arthritis periodontitis. Levels calprotectin are elevated in the gingival crevicular fluid patients periodontitis; however, effects on human fibroblasts ( HGF s) remain unknown. This study investigated proinflammatory activity s functional receptors signaling pathways engaged by calprotectin. Material methods were stimulated...
Human embryonic stem cells (hESCs) have the potential to form any cell type in body, making them attractive sources drug screening, regenerative medicine, disease and developmental processes modeling. However, not all hESC lines equal potency generate desired types vitro. Significant variations been observed for differentiation efficiency of various human ESC lines. The precise underpinning molecular mechanisms are still unclear. In this work, we compared transcriptome four H7, HUES1, HUES8...
Rare but critical bleeding events in primary immune thrombocytopenia (ITP) present life-threatening complications patients with ITP, which severely affect their prognosis, quality of life, and treatment decisions. Although several studies have investigated the risk factors related to large sample size data, consistent definitions, large-scale multicenter findings, prediction models for ITP are unavailable. For first time, this study, we applied newly proposed criteria by International...