A5100421262- Thyroid Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer Immunotherapy and Biomarkers
- Diet, Metabolism, and Disease
- Thyroid Disorders and Treatments
- AI in cancer detection
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Metabolism, Diabetes, and Cancer
- Adrenal Hormones and Disorders
- Diabetes Management and Research
- Hormonal Regulation and Hypertension
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Connective Tissue Growth Factor Research
- Liver Disease Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Metastasis and carcinoma case studies
- Diabetes Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Bioinformatics and Genomic Networks
- Pituitary Gland Disorders and Treatments
Jinzhou Medical University
2024
Fudan University Shanghai Cancer Center
2024
Fujian Medical University
2019-2024
Fujian Provincial Cancer Hospital
2019-2024
North Sichuan Medical University
2024
Nanchong Central Hospital
2024
Beijing Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Chongqing University
2023-2024
Chongqing Cancer Hospital
2024
<h3>Importance</h3> Immune checkpoint inhibitors (ICIs) can elicit durable antitumor responses in patients with non–small cell lung cancer (NSCLC), but only 20% to 25% of respond treatment. As important genes the DNA damage response pathway, comutation tumor protein p53 (<i>TP53</i>) and ataxia-telangiectasia mutated (<i>ATM</i>) may be associated genomic instability hypermutation. However, prevalence of<i>TP53</i>and<i>ATM</i>comutation its association ICIs are not fully understood....
To date, there is no homogeneous evidence of whether earlier age at menopause associated with incident dementia. In addition, the underlying mechanism and driven mediators are largely unknown. We aimed to fill these knowledge gaps.This community-based cohort study included 154,549 postmenopausal women without dementia enrolment (between 2006 2010) from UK Biobank who were followed up until June 2021. Age was entered as a categorical variable (<40, 40-49, ≥50 years) years taken reference. The...
Abstract Background SETD2 protects against genomic instability via maintenance of homologous recombination repair (HRR) and mismatch (MMR) in neoplastic cells. However, it remains unclear whether dysfunction is a complementary or independent factor to microsatellite instability-high (MSI-H) tumor mutational burden-high (TMB-H) for immunocheckpoint inhibitor (ICI) treatment, little known regarding this type acts differently various types cancer. Methods This cohort study used multidimensional...
Abstract Identifying the mechanisms underlying cognitive development in early life is a critical objective. The expression of insulin‐like growth factor binding protein 2 (IGFBP2) hippocampus increases during neonatal and associated with learning memory, but causal connection has not been established. Here, it reported that neurons astrocytes expressing IGFBP2 are distributed throughout hippocampus. enhances excitatory inputs onto CA1 pyramidal neurons, facilitating intrinsic excitability...
Abstract Aero‐disk is a key component of aero‐engine. Due to its complex working conditions, aero‐disk prone structural failures. Therefore, it essential analyze the reliability and importance input variables aero‐disk. In this paper, framework analysis global sensitivity (GSA) was established. First, hazardous regions were determined by finite element analysis, limit state function defined life interference model. Then D‐Vine model utilized establish correlation for evaluate addition, two...
The scarcity, richness, and other important physiological functions of D-psicose make it crucial to increase the yield D-psicose. production can be accomplished by 3-epimerase (DPEase) from Clostridium bolteae (CbDPEase) catalyzing substrate D-fructose. Although catalytic efficiency CbDPEase has been raised via using site-directed mutagenesis (Y68I/G109P) technique, structure-activity relationship in wild-type Y68I/G109P mutant is currently poorly understood. In our study, a battery...
For patients with nasopharyngeal carcinoma (NPC), prognostic indicators to customize subsequent biologically conformal radiation therapy may be obtained via 2-(fluorine-18)-fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT). This retrospective study assessed the significance and feasibility of radiotherapy for NPC, based on F-FDG PET/CT. Eighty-two NPC underwent PET/CT prior intensity-modulated (IMRT). The maximum standardized uptake value (SUVmax)...
Follicular thyroid carcinoma (FTC) is prone to recurrence and hematogenous metastasis, preoperative accurate diagnosis still needed help clinicians select the best surgical methods improve prognosis of patients. The aim this study was find specific conventional ultrasound (US) contrast-enhanced (CEUS) characteristics FTC explore their diagnostic value in differential between follicular adenoma (FA).This retrospective included 258 neoplasms (172 FAs 86 FTCs) 244 consecutive patients who...
Abstract Purpose To evaluate the efficacy and safety of radiofrequency ablation (RFA) for treating calcified benign thyroid nodules (CBTNs). Methods Fifty-two patients with 52 CBTNs who underwent RFA in our hospital were included this retrospective study. According to size calcifications, divided into two groups: punctate echogenic foci (PEF) group macrocalcification group. Moreover, was further subdivided groups, strong weak group, based on their morphologic characteristics. After...
The association between cigarette smoking and thyroid cancer has been reported in prospective cohort studies, but the relationship remains controversial. To investigate this potential correlation further, we employed Mendelian randomization methodology to evaluate causative impact of on incidence.From genome-wide study Sequencing Consortium Alcohol Nicotine use, obtained genetic variants associated with initiation cigarettes per day (1.2 million individuals). We also extracted past tobacco...
Background: Major depressive disorder (MDD) is a common psychiatric with high prevalence of comorbidity subclinical hypothyroidism. The aim this study was to investigate the and factors influencing hypothyroidism in patients dyslipidemic MDD who were hospitalized for first time Chinese population. Methods: incorporated 708 first-time patients, all dyslipidemia. Data collection encompassed socio-demographic information, blood pressure, fasting glucose (FBG), lipid, thyroid hormone levels....
Objective This study aimed to develop and apply a prediction model estimate the probability of lateral lymph node metastasis (LLNM) in patients with cN0 unilateral papillary thyroid carcinoma (PTC) central (CLNM). Setting All data were collected from single tertiary hospital. Methods Univariable multivariable logistic regression analyses used explore independent predictors LLNM derivation internal validation cohorts, which construct validate nomogram. Another 96 included prospectively...
Triglyceride-glucose (TyG) index, as an effective surrogate marker of insulin resistance, has shown predictive value in the risk heart failure patients with coronary artery disease (CAD). This study aims to investigate correlation between TyG index and myocardial work measurements CAD, explore its role detecting early subclinical cardiac dysfunction.
Determining the status of breast cancer susceptibility genes (
This current study aimed to investigate the relationship between triglyceride-glucose (TyG) index and in-hospital all-cause mortality of coronary artery disease (CAD) in patients with different glucose metabolic statuses. Participants were divided into three groups according tertiles TyG index. Glucose status was classified as normal regulation, pre-diabetes mellitus, diabetes mellitus (DM). The primary outcome hospital mortality. We observed a significant deaths CAD this study. After...
To view and evaluate the prognosis factors in patients with nasopharyngeal carcinoma (NPC) treated intensity modulated radiation therapy using nomogram decision curve analysis (DCA).Based on a primary cohort comprising consecutive newly confirmed NPC (n = 1140) between January 2014 December 2015, we identified independent prognostic of overall survival (OS) to establish nomogram. The model was assessed by bootstrap internal validation external an 460 2013 2013. predictive accuracy...