A5079491978- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- Adrenal Hormones and Disorders
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Ion Transport and Channel Regulation
- Neonatal Respiratory Health Research
- Diabetes Management and Research
- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
- Reproductive System and Pregnancy
- Neuroblastoma Research and Treatments
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Pancreatic function and diabetes
- Immune cells in cancer
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
Jilin University
2015-2024
Chinese PLA General Hospital
2023-2024
First Hospital of Jilin University
2024
Beijing Children’s Hospital
2023-2024
Capital Medical University
2023-2024
Traditional Chinese Medicine Hospital of Kunshan
2023
Shanghai University of Traditional Chinese Medicine
2023
Jilin Medical University
1998-2023
First People's Hospital of Yunnan Province
2023
Kunming University of Science and Technology
2023
Exosomes are membranous vesicles actively secreted by almost all cells and they deliver certain intracellular molecules, including nucleic acids, proteins, lipids, to target cells. They also considered be good carriers for drug delivery due their biocompatibility, high permeability, low immunogenicity, toxicity. from immune were reported have immunomodulatory activities. Herein we evaluated the application of exosomes derived expanded natural killer (eNK-EXO) treatment ovarian cancer (OC)....
Background: Macrophages play important roles in the immune response to, and successful implantation of, biomaterials. Titanium nanotubes are considered promising heart valve stent materials owing to their effects on modulation of macrophage behavior. However, nanotube-regulated macrophages endothelial cells, which essential for endothelialization, unknown. Therefore, this study we evaluated inflammatory responses cells titanium prepared at different voltages. Methods results: In used three...
Intraperitoneal injections in the rat of 12 IU ACTH on Days 1, 2 and 3 after mating resulted a marked inhibition both implantation fetal development to 57 29%, respectively, control values, but did not alter rate tubal transport or ova. Following similar treatment with 3, 6 5, 7, were reduced (to 80, 74 57% 75, 61 39%, respectively). About 52% blastocysts transferred from donors receiving 56% untreated developed into normal fetuses when left right uterine horns recipients. Daily 7 implants...
Polyoxometalates (POMs) have shown the potential anti-bacterial, anti-viral and anti-tumor activities. In order to improve their physiological stability antitumour activity for medical application, K2Na[AsIIIMo6O21(O2CCH2NH3)3]·6H2O doped silica nanospheres (POM@SiO2) with diameters of ~40 nm been synthesized by water-in-oil microemulsion method in this study. The obtained spheres were morphologically uniform nanosized nearly monodispersed solution. nanoparticles had high entrapment...
Regulatory T cells (Tregs), as an important subset of cells, play role in maintaining body homeostasis by regulating immune responses and preventing autoimmune diseases. In-depth research finds that Tregs have strong instability plasticity, according to their developmental origin, can be classified into thymic-derived (tTregs), endogenous-induced (pTregs), which are produced antigen-stimulated the periphery vivo, induced (iTregs), differentiate from naïve vitro. In recent years, studies...
Abstract Radiation triage and biological dosimetry are critical for the medical management of massive potentially exposed individuals following radiological accidents. Here, we performed a genome-wide screening radiation-responding mRNAs, whose N6-methyladenosine (m 6 A) levels showed significant alteration after acute irradiation. The m A three genes, Ncoa4 , Ate1 Fgf22 in peripheral blood mononuclear cells (PBMCs) mice excellent dose-response relationships could serve as biomarkers...
Chemodynamic therapy (CDT) is a novel tumor treatment method by using hydroxyl radicals (
Fibroblastic reticular cells (FRCs) in the T cell zone of lymph nodes (LNs) are pivotal for survival, mobility, and peripheral tolerance. Here, we demonstrate that during homeostasis, FRCs also suppress activation via producing high level prostaglandin E2 (PGE2) due to their thousands-fold higher cyclooxygenase-2 (COX-2) expression than immune cells. This hyperactive COX-2/PGE2-induced suppression is evident antigen-specific non-antigen-specific activations. It implicated as suppressed...
The oncogenic roles of lncRNA LINC01116 have been reported in several types cancer, while its involvement gastric cancer is unknown. This study aimed to investigate the cancer.Gene expression was detected by qPCR. Correlations were analyzed linear regression. Overexpression and siRNA silencing techniques used analyze gene functions. Cell invasion migration Transwell assays.LINC01116 CASC11 both upregulated tissues compared cancer-adjacent tissues. Expression levels increased with increase...
The Forkhead box P3 (FOXP3) transcription factor is the key driver of differentiation and immunosuppressive function regulatory T cells (Tregs). Additionally, FOXP3 has been reported to be expressed in many solid tumor cell lines tissues. However, its role tumorigenesis progression conflicting, both suppressive promoting functions have described. In this study, we demonstrated that was lung adenocarcinoma tissues line A549. inhibition decreased proliferation, migration, invasion as well...
Serine incorporator 2 (SERINC2) is a member of the SERINC family transmembrane proteins that incorporate serine into membrane lipids during synthesis. In present study, biological function SERINC2 in lung adenocarcinoma cells was investigated. The data from previous study and publicly available Oncomine database were analysed regarding expression levels mRNA adenocarcinoma. A lentiviral‑based short hairpin RNA (shRNA) used to suppress cancer cells. effect on proliferation determined using...
Objective: Alpinetin is a novel flavonoid that has demonstrated potent antitumor activity in previous studies. However, the efficacy and mechanism of alpinetin treating lung cancer have not been determined. Methods: We evaluated impact different doses durations treatment on cell proliferation, apoptosis cells, as well drug-resistant cells. Results: This study showed inhibited enhanced apoptosis, PI3K/Akt signaling Moreover, significantly increased sensitivity cells to chemotherapeutic effect...
Toll-like receptor 4 (TLR4) is a pattern recognition receptors, member of the family and it serves role in innate acquired immunity. It has previously been reported that TLR4 was overexpressed variety tumor tissues cells, including colorectal cancer, gastric cancer ovarian cancer. In microenvironment, signaling pathway may be activated order to upregulate forkhead box P3 (Foxp3) expression regulatory T cells (Tregs), thus enhance immunosuppressive function Tregs. Also, inflammatory cytokine...
Chemotherapy is the main strategy for treatment of lung cancer. However, sensitivity to chemotherapy, one factors affecting survival rate patients with cancer, extremely poor. Forkhead box P3 (Foxp3) key regulatory gene development and function CD4+CD25+ T cells (Tregs). Increased levels Tregs Foxp3 expression in peripheral blood tumour specimens cancer are associated progression poor prognosis. In addition, certain studies have suggested that may be resistant conventional chemotherapy thus,...
Abstract Hepatocellular carcinoma (HCC) is the fifth most frequent malignancy and second leading cause of cancer‐related death worldwide. Proteasome 26S subunit ATPase 3 interacting protein (PSMC3IP) an oncogene in breast cancer, while its role HCC remains unclear. Here, we found that PSMC3IP was critical for cell proliferation tumorigenic capacity cells. Upregulation observed specimens, high expression predicted poor overall survival patients. In vitro, knockdown blunted colony formation...