A5101751200- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Ginseng Biological Effects and Applications
- Cardiac Arrhythmias and Treatments
- Electrochemical Analysis and Applications
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Cardiovascular Syncope and Autonomic Disorders
- Lipid metabolism and disorders
- Caveolin-1 and cellular processes
- Receptor Mechanisms and Signaling
- Coronary Artery Anomalies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Redox biology and oxidative stress
- Gout, Hyperuricemia, Uric Acid
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neural Engineering
- ECG Monitoring and Analysis
- Organ and Tissue Transplantation Research
- Kawasaki Disease and Coronary Complications
- Apelin-related biomedical research
Peking University First Hospital
2015-2025
Peking University
2015-2025
First Hospital of Shijiazhuang
2024-2025
Third Affiliated Hospital of Sun Yat-sen University
2014-2024
Sun Yat-sen University
2014-2024
Southwest Medical University
2020-2024
Kunming Medical University
2024
Shandong University
2024
Ministry of Education of the People's Republic of China
2019
Hubei University of Medicine
2019
The new anti-anginal drug ranolazine causes a slight (<10 milliseconds) prolongation of the QT interval, raising concern that its use may be associated with an increased incidence torsades de pointes ventricular tachyarrhythmias. goal this study was to show inhibits late component INa and attenuates action potential duration when is increased, both in absence presence IK-blocking drugs. Currents potentials guinea pig isolated myocytes were measured by whole-cell patch clamp. Sea anemone...
Prolongation of the QT interval ECG is associated with increased risk torsades de pointes ventricular tachycardia. Ranolazine, a novel antianginal agent, reported to decrease delayed rectifier potassium current, I<sub>Kr</sub>, and increase action potential duration (APD) interval. However, ranolazine also reduce late sodium current (late I<sub>Na)</sub>, depolarizing that contributes prolongation plateau potential. We hypothesized would APD occurrence arrhythmias when I<sub>Na</sub>...
Assessment of the proarrhythmic risk associated with drugs that prolong QT interval is difficult. We hypothesized activities very low to moderate causing torsades de pointes would be well differentiated when late sodium current (I<sub>NaL</sub>) was greater than normal. The effects selected QT-prolonging on electrical activity female rabbit isolated hearts were determined in absence and presence sea anemone toxin (ATX-II; an enhancer I<sub>NaL</sub>). I<sub>NaL</sub> recorded from...
AimClinical use of amiodarone is associated with occasional development torsade de pointes (TdP). However, preclinical models have failed to demonstrate the proarrhythmic potential amiodarone. The objective this study was reveal and explain pro- anti-arrhythmic effects acute exposure in an animal model.
Purpose: The major cardiac voltage-gated sodium channel Na V 1.5 (I ) is essential for action potential initiation and subsequent propagation. Compound Chinese medicine Wenxin Keli (WXKL) has been shown to suppress arrhythmias heart failure. However, its active components have not fully elucidated. This study focused on identifying the inhibitor of I in WXKL exploring their mode electrophysiological conduction. Methods: A chemical fraction library was constructed from an aqueous extract...
The aim of this study is to investigate the effect hyperuricemia on prognosis drug-eluting stent implantation for coronary bifurcated lesions and value uric acid levels in predicting prognosis. Patients with bifurcation treated were retrospectively enrolled. clinical, interventional follow-up data analyzed. Totally, 308 patients enrolled divided into three groups according levels: group Q1 (N.=105), Q2 (N.=101), Q3 (N.=102). Before PCI, stenosis rate was 0.85 (0.80, 0.90) main artery 0.50...
Advancing age is one of the independent risk factors for cardiovascular disorders. The
Objective: Alpinetin is a novel flavonoid that has demonstrated potent antitumor activity in previous studies. However, the efficacy and mechanism of alpinetin treating lung cancer have not been determined. Methods: We evaluated impact different doses durations treatment on cell proliferation, apoptosis cells, as well drug-resistant cells. Results: This study showed inhibited enhanced apoptosis, PI3K/Akt signaling Moreover, significantly increased sensitivity cells to chemotherapeutic effect...
Dysregulation of intracellular Ca2+ homeostasis is associated with various pathological conditions and arrhythmogenesis the heart. The objective this study was to investigate effects an acute increase in concentration ([Ca2+]i) on electrophysiology ventricular myocytes by mimicking overload. [Ca2+]i clamped either a controlled (65–100 nmol L−1) or increased (1 μmol level. transmembrane action potentials ionic currents were recorded using whole-cell patch clamp techniques. We found that...
Age-related myocardial dysfunction is a very large healthcare burden. Here, we aimed to investigate whether ginsenoside Rb1 (Rb1) improves age-related and identify the relevant molecular mechanism. Young mice aged were injected with or vehicle for 3 months. Then, their cardiac function was inspected by transthoracic echocardiography. Serum myocardium tissue collected from all histological expression analyses, including aging-related proteins, markers fibrosis inflammation, indicating...
Inhibition of human ether‐a‐go‐go‐related gene (hERG) potassium channel is responsible for acquired long QT syndromes, which leads to life‐threatening cardiac arrhythmia. A multikinase inhibitor, vandetanib, prolongs the progression‐free survival time in advanced medullary thyroid cancer. However, vandetanib has been reported induce significant interval prolongation, limits its clinical application. Some studies have showed that ginsenoside Rg3 decelerated hERG K(+) tail current...
Hydroxychloroquine (HCQ), clinically established in antimalarial and autoimmune therapy, recently raised cardiac arrhythmogenic concerns when used alone or with azithromycin (HCQ+AZM) Covid-19. We report complementary, experimental, studies of its electrophysiological effects. In patch clamped HEK293 cells expressing human ion channels, HCQ inhibited IKr IK1 at a therapeutic concentrations (IC50s: 10 ± 0.6 34 5.0 μM). INa ICaL showed higher IC50s; Ito IKs were unaffected. AZM slightly INa,...
Context Ginsenoside Rb1 (Rb1) exerts many beneficial effects and protects against cardiovascular disease.Objective To investigate whether could attenuate age-related vascular impairment identify the mechanism.Materials methods Female C57BL/6J mice aged 2 18 months, randomly assigned to Young, Young + 20 mg/kg Rb1, Old vehicle, 10 groups, were daily intraperitoneal injected with vehicle or for 3 months. The thoracic aorta segments used inspect endothelium-dependent vasorelaxation. Left...
Percutaneous coronary intervention (PCI) is effective in treating patients with acute syndrome (ACS) but associated some serious complications. Nicorandil an anti-anginal agent acting to improve microvascular circulation and increase blood flow. The objective of this article evaluate the effects intracoronary injection followed continuous intravenous nicorandil on ECG parameters unstable angina pectoris (UA) undergoing PCI.A single-center, self-controlled clinical trial was conducted at...
Abstract To investigate the instent restenosis rate of sirolimus-coated stents in percutaneous coronary intervention (PCI) and risk factors for in-stent restenosis, patients with unstable angina (UA) caused by artery stenosis were enrolled, all clinical imaging data analyzed. Among 143 enrolled UA aged 35–83 (mean 60.9 ± 10.0) years there 114 (79.7%) male 29 (20.3%) female patients. Arterial was present one 6 (4.2%) patients, two arteries 20 (14.0%) three 116 (81.1%), four 1 (0.7%) patient....