A5078938441- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Airway Management and Intubation Techniques
- Pleural and Pulmonary Diseases
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Salivary Gland Tumors Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Advanced biosensing and bioanalysis techniques
- Head and Neck Cancer Studies
- Colorectal and Anal Carcinomas
- Surgical Simulation and Training
- Esophageal and GI Pathology
- Cancer-related gene regulation
Xi'an Jiaotong University
2025
Union Hospital
2025
Fujian Medical University
2025
University of Maryland, Baltimore
2020-2024
First Affiliated Hospital of Guangzhou Medical University
2012-2023
Guangzhou Medical University
2012-2023
State Key Laboratory of Respiratory Disease
2011-2023
National Clinical Research Center for Digestive Diseases
2016-2022
National Clinical Research
2019-2021
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2020-2021
Purpose We investigated the correlation between number of examined lymph nodes (ELNs) and correct staging long-term survival in non–small-cell lung cancer (NSCLC) by using large databases determined minimal threshold for ELN count. Methods Data from a Chinese multi-institutional registry US SEER database on stage I to IIIA resected NSCLC (2001 2008) were analyzed relationship count migration overall (OS) multivariable models. The series mean positive LNs, odds ratios (ORs), hazard (HRs)...
According to the lung cancer staging project, T1a (≤ 2 cm) non-small-cell (NSCLC) should be additionally classified into ≤ 1 cm and > groups. This study aimed investigate surgical procedure for NSCLC cm.We identified 15,760 patients with T1aN0M0 after surgery from Surveillance, Epidemiology, End Results database. Overall survival (OS) cancer-specific (LCSS) were compared among lobectomy, segmentectomy, or wedge resection. The proportional hazards model was applied evaluate multiple...
Importance Indocyanine green (ICG)–guided lymphadenectomy has been increasingly used to treat gastric cancer. However, its oncologic impact remains unclear. Objective To investigate the effect of ICG tracing on long-term outcomes in patients diagnosed with locally advanced cancer undergoing neoadjuvant chemotherapy (NAC) followed by laparoscopic radical gastrectomy. Design, Settings, and Participants This retrospective cohort study included cT2-4N0/+M0 adenocarcinoma who underwent NAC...
The discovery of Warburg effect opens a new era in anti-cancer therapy. Aerobic glycolysis is regarded as hallmark cancer cells and increasing literatures indicates that metabolic changes are critical for the maintenance progression cells. Besides aerobic glycolysis, increased fatty acid synthesis also required rapid growth cells, considered one most typical symbols either. Thus, targeting metabolism may provide potential avenue diagnosis therapeutic treatment cancer. In this study, we have...
Cancer cells are characterized by aberrant activation of lipid biosynthesis, producing saturated fatty acids and monounsaturated via stearoyl-CoA desaturases (SCD) for regulating metabolic signaling platforms. SCD1 overexpression functions as an oncogene in lung cancer predicts a poor clinical outcome. This study aimed to investigate the role inhibition EGFR inhibitor (Gefitinib)-based anti-tumor therapy both vitro vivo. CCK-8 assay was performed determine cell viability. The mRNA level...
Esophageal cancer is one of the leading causes death worldwide. A deeper understanding trends in annual incidence, mortality, and disability-adjusted life-years (DALYs) esophageal critical for management prevention. In this study, we report on disease burden 204 countries territories between 1990 2019 by age, sex, sociodemographic index (SDI).Data DALYs were extracted from Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2019. The estimated numbers age-standardized rates are...
Pulmonary lymphoepithelioma-like carcinoma (LELC) is one of the rare histological non-small cell lung cancers. Only a few case reports have been published. The knowledge its characteristics and prognosis in western population limited. Based on data Surveillance, Epidemiology, End Results database (SEER), an analysis was performed to fill gap our knowledge.Characteristics, treatment outcomes all pulmonary LELC patients extracted both from SEER 1973 2011 using SEER*Stat 8.2.1 statistical SPSS...
Small cell lung cancer (SCLC) is a subtype of with poor prognosis. In this study, we aimed to build nomogram predict the survival individual SCLC by incorporating significant clinical parameters.The patients were enrolled from First Affiliated Hospital Guangzhou Medical University (GMUFAH) between 2009 and 2013. We identified incorporated independent prognostic factors patients. The predictive accuracy discriminative ability evaluated concordance index (C-index) calibration curve. also...
Chronic pain alters the configuration of brain functional networks. Primary dysmenorrhea (PDM) is a form chronic visceral pain, which has been identified spatial alterations in networks using static connectivity analysis methods. However, dynamics during pain-free periovulation phase remain unclear. Using co-activation pattern (CAP) method, we investigated dynamic network characteristics and their relationship with pain-related emotions sample 59 women PDM 57 demographically matched healthy...
Thoracic pleural empyema is a collection of pus within thoracic cavity. In stage 2 (fibrinopurulent) and 3 (organizational), decortication the only choice. But there no consensus on whether to choose video-assisted thoracoscopic (VATD) or open thoracotomy (OTD). We sought answer this question by performing meta-analysis.Six electronic databases were searched. Primary outcomes operative time, postoperative hospital stay, prolonged air leak, chest tube duration, relapse rate, morbidity...
To explore the effectiveness of video-assisted thoracoscopic surgery (VATS) bronchial sleeve resection and reconstruction.The clinical data patients who had received VATS lobectomy in our center from January 2008 to February 2015 were retrospectively analyzed.Totally 118 (105 men 13 women) lobectomy. The procedures included right upper lobe (n=59), middle (n=7), lower (n=8), left (n=34), (n=10). lesions confirmed be squamous cell carcinoma (n=68), adenocarcinoma (n=16), mucoepidermoid...
The histone demethylase KDM4B functions as a key co-activator for the androgen receptor (AR) and plays vital in multiple cancers through controlling gene expression by epigenetic regulation of H3K9 methylation marks. Constitutively active confers anti-androgen resistance advanced prostate cancer. However, role to next-generation anti-androgens mechanisms are poorly defined. Here we found that is overexpressed enzalutamide-resistant cancer cells. Overexpression promoted recruitment AR c-Myc...
Currently, blockade of the programmed cell death 1 (PD-1)/PD-1 ligand (PD-L1) signaling pathway has been proved one most promising immunotherapeutic strategies against cancer. Several antibodies have developed to either block PD-1 or its PD-L1 are under development. So far, a series phase I trials on PD-1/PD-L1 for non-small lung cancer (NSCLC) completed, without reports results from II studies. Thus, we sought perform meta-analysis incorporating all available evidences evaluate efficacy and...
Background To date, few studies have evaluated the impact of lobectomy versus sublobar resection for early small cell lung cancer (SCLC). We investigated survival rates patients with pathological stage T1‐2N0M0 SCLC who underwent or resection. Methods identified 548 in Surveillance, Epidemiology, and End Results database Propensity score matching (PSM) Cox regression analysis were used to adjust baseline characteristics. The three‐year overall (OS) treated ( n = 376, 60%) was significantly...