A5110466733- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Gastric Cancer Management and Outcomes
- Pleural and Pulmonary Diseases
- Ferroptosis and cancer prognosis
- Tracheal and airway disorders
- Cancer therapeutics and mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune cells in cancer
- Sarcoma Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Multiple and Secondary Primary Cancers
- Cancer, Stress, Anesthesia, and Immune Response
- HER2/EGFR in Cancer Research
- Airway Management and Intubation Techniques
- Social Media in Health Education
- Cell death mechanisms and regulation
- Transplantation: Methods and Outcomes
Sichuan University
2021-2024
West China Hospital of Sichuan University
2022-2024
First Affiliated Hospital of Guangzhou Medical University
2015-2021
Guangzhou Medical University
2015-2021
State Key Laboratory of Respiratory Disease
2015-2021
National Clinical Research Center for Digestive Diseases
2017-2020
Washington University in St. Louis
2018
Immunotherapy has become a pillar of advanced solid tumors treatment. Patients are more likely to benefit from neoadjuvant immunotherapy compared with traditional therapy. However, the safety and efficacy for treatment locally advanced, surgically resectable Esophageal squamous cell carcinoma (ESCC) remain unknown.ESCC patients who received following minimally invasive esophagogastrostomy were enrolled June 2020 September 2021. The characteristics surgery investigated determine combination...
It has been confirmed that epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) presented better efficacy than brain radiotherapy (brain RT) in the treatment of metastasis (BM) EGFR mutated NSCLC patients. However, whether combination EGFR-TKIs and RT is alone remains unclear. We aim to compare outcomes adding screen for beneficial population by a meta-analysis currently available data.A systematic search relevant articles was conducted six databases. The were overall...
Epidermal growth factor receptor (EGFR) mutation represents a good response to EGFR-tyrosine kinase inhibitor and an advantageous prognostic in advanced-stage non-small cell lung cancer (NSCLC). However, the predictive value of EGFR for prognosis NSCLC patients after complete surgery, which more reflective natural process, remains controversial. We sought examine NSCLC. Several studies with small sample sizes have been reported but bring bias especially postoperative setting. Therefore, we...
Background To date, few studies have evaluated the impact of lobectomy versus sublobar resection for early small cell lung cancer (SCLC). We investigated survival rates patients with pathological stage T1‐2N0M0 SCLC who underwent or resection. Methods identified 548 in Surveillance, Epidemiology, and End Results database Propensity score matching (PSM) Cox regression analysis were used to adjust baseline characteristics. The three‐year overall (OS) treated ( n = 376, 60%) was significantly...
The correlation between the number of examined lymph nodes (ELNs) and lung cancer-specific survival (LCSS) stage IA non-small cell cancer (NSCLC) patients, who underwent sublobar resection in which node (LN) sampling was relatively restricted as compared with standard lobectomy remains unclear.Patients from Surveillance, Epidemiology, End Results database NSCLC were categorized based on ELN count (1-6 vs. ≥7; cut point 7 identified by Cox model).Collectively, 3,219 patients a median...
Background: The aims of this study were to analyze the association LMO4 with non-small-cell lung cancer (NSCLC) survival rate, and determine its functional role signaling pathway in cancer. Methods: Immunohistochemistry (IHC) was used detect expression NSCLC cell lines tumor tissues. Migration invasion ability detected respectively by wound healing test transwell test. Immunofluorescence western blot AKT/PI3K related genes MAPK, PI3K, AKT. Results: has high level tissues, correlated a lower...
X-ray radiation resistance associated 1 (XRRA1) has been found to regulate the response of human tumor and normal cells X-radiation (XR). Although XRRA1 overexpression is known be involved in cancer cell XR, there are no reports about whether expression tumors can adjust radioresistance. It widely that cycle arrest could cause We blocked lead G2/M by regulation cyclin A, E, p21 proteins colorectal (CRC) reduced increased proliferation CRC. However, influence radioresistance poorly...
Compared with male, female non-small cell lung cancer (NSCLC) patients have better response when treated epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), suggesting a potential association between hormones and EGFR mutation. However, the results provided by previous studies were inconclusive controversial. We sought to examine link expression of nuclear hormone receptors mutations in NSCLC.Electronic databases used search relevant articles. The involved included...
Abstract This study aimed to analyze the association between driver mutations and predictive markers for some anti–tumor agents in non–small cell lung cancer ( NSCLC ). A cohort of 785 Chinese patients with who underwent resection from March 2016 November 2017 First Affiliated Hospital Guangzhou Medical University was investigated. The specimens were subjected hybridization capture sequence 8 important ‐related genes. In addition, slides tested PD ‐L1, excision repair cross‐complementation...
Several randomized controlled trials have suggested that adjuvant epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) were associated with prolonged disease-free survival (DFS) in EGFR-mutated NSCLC patients after radical resection, comparing chemotherapy or placebo. We aimed to compare the effectiveness of different first-generation EGFR-TKIs as treatment real-world setting.Early-stage EGFR mutated who underwent resection and treated (gefitinib, erlotinib, icotinib)...
The most common form of therapy for nonsmall cell lung cancer (NSCLC) in early stage is surgery-based combination therapy, including radiotherapy and immunotherapy. However, postoperative (PORT) correlated with increasing risk second primary malignancy (SPM), especially young-onset cases. authors aimed to quantify the risks SPM associated PORT treatment young‑onset NSCLC stage.
Abstract Not all patients can benefit from chemotherapy due to the various of tumor type, stage, location, and different distribution immune cells in microenvironment (TIME). Immune are widely involved every step cancer progression, including escape, metastasis, drug response, prognosis. In this study, we explored transcriptome data 10 solid tumors treated with identify role cells. We downloaded mutation cancers TCGA databases, used ESTIMATE CIBERSORT algorithms assess proportion TIME....
The drug therapy for non-small cell lung cancer (NSCLC) have always been issues of poisonous side effect, acquired resistance and narrow applicable population. In this study, we built a novel network analysis method (difference- correlation- enrichment- causality- node), which was based on the difference analysis, Spearman correlation biological function Bayesian causality to discover new therapeutic target NSCLC in sequencing data BEAS-2B 7 lines. Our results showed that, as proteasome...
Currently, some studies have shown that early removal of a chest tube after video-assisted thoracoscopic surgery (VATS) lobectomy is safe and can shorten the length hospital stay. The purpose our study was to retrospectively analyze association between stay in patients who undergone lobectomy.This retrospective analysis included undergoing different types lung resections including wedge resection. Consecutive underwent VATS or resection (March 2018 April 2019) for tumor were analyzed....
We present an innovative method using uniportal video-assisted thoracoscopic surgery under spontaneous ventilation anaesthesia (SVA) to perform tracheal in a 46-year-old man with distal squamous cell carcinoma. SVA offered better exposure of the surgical field and facilitated anastomosis following single incision. Such simplification strategy incision accelerated postoperative recovery reduced side effects conventional anaesthesia.
Recent studies have demonstrated benefits from adjuvant tyrosine-kinase inhibitors (TKIs) compared with chemotherapy in non-small cell lung cancer. We launched a multi-center retrospective study to evaluate the efficacy and toxicity of TKIs or without epidermal growth factor receptor (EGFR)-mutant stage III-pN2 adenocarcinoma.Two hundred seventy-four consecutive cases adenocarcinoma complete resection been investigated. Clinic-pathologic characteristics, treatments, long-term survivals,...
Embryonal rhabdomyosarcoma (ERMS) is associated with a low prevalence, poor prognosis, and limited treatment efficacy. Here, we report case of 21-year-old male whose disease relapsed in the thoracic cavity following traditional chemotherapy. The patient received eight sequential cycles chemotherapy using combination cyclophosphamide + vincristine doxorubicin hydrochloride liposome (CAV) etoposide ifosfamide (IE) regimens. therapeutic effect regimen had been worked short times. After month,...
National Comprehensive Cancer Network (NCCN) guidelines recommend video-assisted thoracoscopic surgery (VATS) anatomical lobectomy as the first choice for treatment of resectable lung cancer. However, sublobar resection offers significantly better functional preservation compared with stage I At present, inferiority to is still uncertain. Herein, we prognoses these two types surgical adenocarcinoma.