A5100421435- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Adrenal Hormones and Disorders
- Dermatology and Skin Diseases
- Systemic Lupus Erythematosus Research
- Aquaculture disease management and microbiota
- Diabetes and associated disorders
- Psoriasis: Treatment and Pathogenesis
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Retinal Imaging and Analysis
- Ubiquitin and proteasome pathways
- Galectins and Cancer Biology
- Inflammation biomarkers and pathways
- Immune cells in cancer
- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
- Protein purification and stability
- Fish Biology and Ecology Studies
- Vibrio bacteria research studies
- Macrophage Migration Inhibitory Factor
- Invertebrate Immune Response Mechanisms
- Peptidase Inhibition and Analysis
- Biosimilars and Bioanalytical Methods
Xi'an Jiaotong University
2024
Xi'an Honghui Hospital
2024
Inner Mongolia Agricultural University
2023-2024
South China Agricultural University
2023
Agriculture Fisheries and Conservation Department
2023
Key Laboratory of Guangdong Province
2023
Jilin University
2015-2021
Tianjin Medical University General Hospital
2019
Xiangya Hospital Central South University
2017
Central South University
2017
Abstract Physical contact between thymocytes and the thymic stroma is essential for T cell maturation shapes repertoire in periphery. Stromal elements that control these processes still remain elusive. We used a mouse strain with mutant NF-κB-inducing kinase (NIK) to examine mechanisms underlying breakdown of self-tolerance. This NIK-mutant manifests autoimmunity disorganized structure abnormal expression Rel proteins stroma. Production immunoregulatory cells autoreactive was impaired mice....
Regulatory T cells (Tregs), as an important subset of cells, play role in maintaining body homeostasis by regulating immune responses and preventing autoimmune diseases. In-depth research finds that Tregs have strong instability plasticity, according to their developmental origin, can be classified into thymic-derived (tTregs), endogenous-induced (pTregs), which are produced antigen-stimulated the periphery vivo, induced (iTregs), differentiate from naïve vitro. In recent years, studies...
Naturally selected T-cell receptors (TCRs) are characterised by low binding affinities, typically in the range 1–100 µM. Crystal structures of syngeneic TCRs bound to peptide major histocompatibility complex (pMHC) antigens exhibit a conserved mode distinct diagonal geometry, with poor shape complementarity (SC) between receptor and ligand. Here, we report three vitro affinity enhanced that recognise pMHC tumour epitope NY-ESO157–165 (SLLMWITQC). These crystal reveal docking for high is...
Abnormal CD4+ T cell activation is known to play roles in the pathogenesis of myasthenia gravis (MG). However, little about mechanisms underlying lncRNAs regulating cell. In this study, we discovered that lncRNA IFNG-AS1 abnormally expressed MG patients associated with quantitative (QMG) and positive anti-AchR Ab levels patients. influenced Th1/Treg proliferation regulated expression their transcription factors an experimental autoimmune (EAMG)model. could reduce HLA-DRB HLA-DOB they had a...
Abstract Purpose To evaluate the disease burden of age‐related macular degeneration (AMD) and to risk factors disability‐adjusted life years (DALY) caused by AMD. Methods Country‐specific DALY number, rate age‐standardized AMD were acquired from Global Burden Disease Study 2017 database. The Socio‐demographic Index (SDI), Human Development (HDI), Inequality‐adjusted (IA‐HDI) other related data obtained published or shared databases. Regression analysis was conducted correlations between...
Although ectopic lymphoid tissue formation is associated with many autoimmune diseases, it unclear whether serves a functional role in responses. 2,6,10,14-Tetramethylpentadecane causes chronic peritoneal inflammation and lupus-like disease autoantibody production (lipogranuloma) formation. A novel transplantation model was used to show that transplanted lipogranulomas retain their structure over prolonged period the absence of inflammation. Recipients produced anti-U1A autoantibodies...
The expression of peripheral antigens in the thymus, known as promiscuous gene expression, has been implicated T cell tolerance and autoimmunity. Here we identified thymic epithelial cells (TECs) main type that expresses a diverse range tissue-restricted (TRAs). TECs common autoimmune (non-obese diabetic [NOD]) mouse model express much lower levels an regulator (Aire) TRAs than normal (Balb/c) TECs. Transfection Aire plasmid led to increased TRA cultured from Balb/c NOD mice; increase was...
Tail rot disease is the cause of significant economic damage in freshwater farmed Murray cod Maccullochella peelii. Only scarce information available on Aeromonas hydrophila as a possible causal agent for this disease. In study, virulent strain, temporarily named XY3, was isolated from diseased codfish suffering tail disease, and identified A. through phylogenetic analysis phenotypic characteristics. possesses multiple virulence genes including aerA, ahpA, alt, ast hlyA genes. addition, it...
The autoimmune regulator (Aire) protein is a transcriptional activator that essential in central immune tolerance, as it regulates the ectopic expression of many tissue‑restricted antigens medullary thymic epithelial cells. Aire has also been described hematopoietic cells, such monocytes/macrophages and dendritic cells (DCs), peripheral system. However, role system including DCs, remains to be elucidated. In present study, effects secreted cytokines from Aire‑overexpressing DCs on cluster...
Autoimmune regulator (Aire) mutations result in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), which manifests as multi-organ autoimmunity and chronic mucocutaneous (CMC). Indendritic cells (DCs), pattern recognition receptors (PRR), such Toll-like (TLRs), are closely involved the of various pathogens, activating intercellular signaling pathway, followed by activation transcription factors expression downstream genes, take part mediating immune response maintaining...
Camelids produce both conventional tetrameric antibodies (Abs) and dimeric heavy-chain (HCAbs). Although B cells that generate these two types of Abs exhibit distinct cell receptors (BCRs), whether populations differ in their phenotypes developmental processes remains unclear. Here, we performed single-cell 5' RNA profiling peripheral blood mononuclear samples from Bactrian camels before after immunization. We characterized the functional subtypes differentiation trajectories circulating...
In the past decade, a group of cases with persisting haemocytopenia were separated from those idiopathic cytopenia undetermined significance due to optimal response these patients immunosuppression therapy and detection autoantibodies in bone marrow haemopoietic cells. This condition was termed immune‑related (IRH). However, quantity T lymphocytes remained unknown. present study, percentage CD4+ T‑cell subsets related cytokines measured using flow cytometry an enzyme‑linked immunosorbent...
Empiric probiotics are commonly consumed by healthy individuals as a means of disease prevention, pathogen control, etc. However, controversy has existed for long time regarding the safety and benefits probiotics. Here, two candidate probiotics, Lactiplantibacillus plantarum Pediococcus acidilactici, which antagonistic to Vibrio Aeromonas species in vitro, were tested on Artemia under vivo conditions. In bacterial community nauplii, L. reduced abundance genera P. acidilactici significantly...
Abstract Camelids are capable of producing both conventional tetrameric antibodies (Abs) and dimeric heavy-chain (HCAbs). While B cells generating these two types Abs exhibit distinct B-cell receptors (BCRs), it remains unclear whether cell populations differ in their phenotypes developmental processes. Here, we collected eight PBMC samples before after immunization from four Bactrian camels conducted single-cell 5’ RNA sequencing. We characterized the functional subtypes differentiation...