A5037511763- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Myasthenia Gravis and Thymoma
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- RNA Research and Splicing
- Viral-associated cancers and disorders
- Alzheimer's disease research and treatments
- Cancer Cells and Metastasis
- Neurogenesis and neuroplasticity mechanisms
- Metal complexes synthesis and properties
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Antifungal resistance and susceptibility
- RNA Interference and Gene Delivery
- Cellular transport and secretion
- Ubiquitin and proteasome pathways
- Crystallization and Solubility Studies
- Signaling Pathways in Disease
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Diet and metabolism studies
Hubei University of Medicine
2013-2025
Central South University
2015-2024
Xiangya Hospital Central South University
2015-2024
Zhejiang Sci-Tech University
2024
Guilin Medical University
2017-2021
Northeast Agricultural University
2020
Northeast Forestry University
2020
China Minmetals (China)
2020
Guangxi Academy of Special Crops
2017
Dawu County People's Hospital
2014
MicroRNAs have been considered as a kind of potential novel biomarker for cancer detection due to their remarkable stability in the blood and characteristics expression profile many diseases.We performed microarray-based serum miRNA profiling on twenty nasopharyngeal carcinoma patients at diagnosis along with 20 non-cancerous individuals controls. This was followed by real-time quantitative Polymerase Chain Reaction (RT-qPCR) separate cohort thirty age- matched volunteers. A model...
Dysregulation of microRNA (miRNA) biogenesis is implicated in cancer development and progression. Dicer Drosha are established regulators miRNA biogenesis. In this study, we used a array to evaluate the expression profiles nasopharyngeal carcinoma (NPC) samples. The significance analysis microarrays showed global downregulation NPC samples compared with normal epithelial tissues. Notably, miR-18a, member oncogenic miR-17–92 cluster, was upregulated ell lines. Clinical parameter studies that...
MicroRNAs (miRNAs) are small non-coding RNAs that participate in the spatiotemporal regulation of messenger RNA (mRNA) and protein synthesis. Recent studies have shown some miRNAs involved progression nasopharyngeal carcinoma (NPC). However, aberrant implicated different clinical stages NPC remain unknown their functions not been systematically studied.In this study, miRNA microarray assay was performed on biopsies from NPC. TargetScan used to predict target genes miRNAs. The gene list...
The Epstein-Barr virus (EBV) is highly associated with nasopharyngeal carcinoma (NPC), and it regulates some microRNAs (miRNAs) that are involved in the development of cancer. role EBV deregulation cellular miRNAs how this affects progression NPC remain to be investigated. An analysis miRNA profile an EBV-infected cell line revealed 203 (miR-203) was downregulated. miR-203 expressed specifically epithelial cells. This downregulation further verified functionally analyzed. downregulated...
miRNA-27a-3p is an important regulator of carcinogenesis and other pathological processes. However, its role in laryngeal carcinoma still unknown. In our previous research, we found that miR-27a-3p expression was upregulated nasopharyngeal (NPC) using a microarray chip. the present study, identified as endogenous promoter metastatic invasion. The levels were correlated with human progression outcomes Kaplan-Meier survival. silico database analyses revealed Mapk10 potential target miR-27a-3p,...
Abstract Mesial temporal lobe epilepsy (MTLE) is a common epileptic disorder; little known whether it associated with peripheral epigenetic changes. Here we compared blood whole genomic DNA methylation pattern in MTLE patients (n = 30) relative to controls the Human Methylation 450 K BeadChip assay, and explored genes pathways that were differentially methylated using bioinformatics profiling. The control groups showed significantly different (P < 1.03e-07) at 216 sites, 164 sites...
Abstract Myasthenia gravis (MG) is a rare autoimmune disease. Although the impact of immune cell disorder in MG has been extensively studied, little known about transcriptomes individual cells. Here, we assessed transcriptional profiles 39,243 cells by single-cell sequencing and identified 13 major clusters, along with 39 subgroups derived from patients new-onset myasthenia healthy controls. We found that B cells, CD4 + T monocytes exhibited more heterogeneity patients. were expanded...
The pectoral nerve (PecS) II block is a recently introduced technique utilized for surgical anesthesia and postoperative analgesia during breast surgery. This study aims to investigate the impact of ultrasound-guided PecS on incidence chronic postmastectomy pain in patients following radical mastectomy. Ninety-eight undergoing selective mastectomy were included this study. Based whether was performed, randomly divided into group (group P) control C). primary outcomes at 12 weeks after...
The Neurospora crassa arg-2 transcript contains an upstream open reading frame (uORF) specifying a 24-residue leader peptide and is subject to novel form of negative translational regulation in response arginine. role the uORF arginine-specific was investigated by using fusions wild-type mutant sequences Escherichia coli lacZ reporter gene beta-galactosidase. conferred Arg-specific on N. crassa, but mutated or truncated uORFs did not, as determined measurements beta-galactosidase activity...
Abnormal CD4+ T cell activation is known to play roles in the pathogenesis of myasthenia gravis (MG). However, little about mechanisms underlying lncRNAs regulating cell. In this study, we discovered that lncRNA IFNG-AS1 abnormally expressed MG patients associated with quantitative (QMG) and positive anti-AchR Ab levels patients. influenced Th1/Treg proliferation regulated expression their transcription factors an experimental autoimmune (EAMG)model. could reduce HLA-DRB HLA-DOB they had a...
// Yafei Dai 1, 2 , Lujuan Wang Jingqun Tang 3 Pengfei Cao Zhaohui Luo 2, 5 Jun Sun Abraha Kiflu Buqing Sai Meili Zhang Fan Guiyuan Li 4 Juanjuan Xiang 1 Hunan Cancer Hospital and The Affiliated of Xiangya School Medicine, Central South University, Changsha, Hunan, PR China Research Institute, Key Laboratory Carcinogenesis Invasion Ministry Education, Health, Department Thoracic Surgery, Second Hospital, Nonresolving Inflammation Cancer, Neurology, Correspondence to: Xiang, e-mail:...
A novel class of transcripts, long non-coding RNAs (lncRNAs), has recently emerged as a key player in several biological processes, and important roles for these molecules have been reported number complex human diseases, such autoimmune neurological disorders, various cancers. However, the aberrant lncRNAs implicated myasthenia gravis (MG) remain unknown. The aim present study was to explore abnormal expression peripheral blood mononuclear cells (PBMCs) examine mRNA regulatory relationship...