A5100339195- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Single-cell and spatial transcriptomics
- Mycobacterium research and diagnosis
- Cytokine Signaling Pathways and Interactions
- Glycosylation and Glycoproteins Research
- Inflammatory mediators and NSAID effects
- Sirtuins and Resveratrol in Medicine
- CAR-T cell therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Salivary Gland Disorders and Functions
- Bioinformatics and Genomic Networks
- Angiogenesis and VEGF in Cancer
- Atherosclerosis and Cardiovascular Diseases
- Genomics and Phylogenetic Studies
- Virus-based gene therapy research
- Chemokine receptors and signaling
- Genetic and phenotypic traits in livestock
- Genetic Associations and Epidemiology
University of South China
2023-2024
The University of Texas MD Anderson Cancer Center
2024
First Affiliated Hospital of University of South China
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2023
Xi'an Jiaotong University
2023
Stomatology Hospital
2018-2023
Tongji University
2023
Central Hospital of Zibo
2022
First Affiliated Hospital of Soochow University
2022
Soochow University
2022
Abstract Identifying cell populations associated with risk variants is essential for uncovering cell-specific mechanisms that drive disease development and progression. Integrating genome-wide association studies (GWAS) single-cell RNA sequencing (scRNA-seq) has become an effective strategy detecting trait–cell relationships. The accumulation of trait-related single data led to urgent need its comprehensively processing. To address this, we developed sc2GWAS...
Prostate cancer has become the most commonly diagnosed and second leading cause of cancer-related deaths in males. The long noncoding RNA chromosome locus associated with prostate-1 (SChLAP1) been found to be overexpressed a subset prostate cancer. However, significance mechanism SChLAP1 are not well known. In this study, we explored role tissues, cell lines, mouse models. effect on miR-198 MAPK1 was specifically examined. We that expression significantly increased cells tissues. Knockdown...
Abstract Long non-coding RNAs (lncRNAs) possess a wide range of biological functions, and research has demonstrated their significance in regulating major processes such as development, differentiation, immune response. The accelerating accumulation lncRNA greatly expanded our understanding functions. Here, we introduce LncSEA 2.0 (http://bio.liclab.net/LncSEA/index.php), aiming to provide more comprehensive set functional lncRNAs enhanced enrichment analysis capabilities. Compared with 1.0,...
Gastric cancer (GC) is one of the most lethal malignant tumors worldwide with poor outcomes. Vascular mimicry (VM) an alternative blood supply to that independent endothelial cells or angiogenesis. Previous studies have shown VM was associated prognosis in patients GC, but underlying mechanisms and relationship between immune infiltration GC not been well studied.In this study, expression profiles from VM-related genes were retrieved The Cancer Genome Atlas (TCGA) Gene Expression Omnibus...
A novel class of transcripts, long non-coding RNAs (lncRNAs), has recently emerged as a key player in several biological processes, and important roles for these molecules have been reported number complex human diseases, such autoimmune neurological disorders, various cancers. However, the aberrant lncRNAs implicated myasthenia gravis (MG) remain unknown. The aim present study was to explore abnormal expression peripheral blood mononuclear cells (PBMCs) examine mRNA regulatory relationship...
Over the past decades, prevalence of type 2 diabetes mellitus (T2D) has been steadily increasing around world. Despite large efforts devoted to better understand genetic basis disease, identified susceptibility loci can only account for a small portion T2D heritability. Some existing approaches proposed high dimensional data from case–control study are limited by analyzing few number SNPs at time pool SNPs, ignoring correlations among and adopting inefficient selection techniques. We propose...
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies in world, marked by dysphagia and weight loss, bringing great suffering to patients. HNF1A‑AS1 (HAS1), a long non-coding RNA (lncRNA), has been identified prevalently involved various human cancers. However, exact effects molecular mechanisms HAS1 ESCC progression are still elusive. In this study, upregulated expression was detected tissues four lines (KYSE70, KYSE450, EC109 EC970) compared with normal lines....
Breast cancer is an aggressive disease with high morbidity and mortality rates among women globally. Tumor protein D52 (TPD52) oncogene in breast cancer; however, its physiological function remains elusive. This study set out to obtain a deeper understanding of the functions TPD52 pathophysiology by exploring effects on cell proliferation migration.Bioinformatics analysis was performed predict bonding nuclear paraspeckle assembly transcript 1 (NEAT1) miR-218-5p. The NEAT1 miR-218-5p were...
Abstract Background It has been found that microRNAs (miRNAs) play important roles in the regulation of tooth development, and most likely increase complexity genetic network, thus lead to greater teeth. But there no research about key associated with morphogenesis based on miRNAs expression profiles. Compared mice, pig model plentiful types teeth, which is similar human dental pattern. Therefore, we used miniature pigs as large-animal models investigate differentially expressed during early...
Atherosclerosis can lead to multiple cardiovascular diseases, especially myocardial infarction. Long noncoding RNAs (lncRNAs) are involved in including atherosclerosis. LncRNA HOXA-AS3 was found be notably upregulated However, the biological function of during occurrence and development atherosclerosis remains unclear.Human vascular endothelial cells (HUVECs) were treated with oxidized low-density lipoprotein (oxLDL) mimic vitro. Gene protein expressions HUVECs detected by RT-qPCR Western...
Abstract Intestinal mucosal injury is one of the most significant complications burns. In our previous study, it was found that autophagy could alleviate burn‐induced intestinal injury, but underlying mechanisms are still unclear. Irregular expression long noncoding RNAs (lncRNAs) present in many diseases, including However, relationship between lncRNAs and requires further elucidation. this we established a burn mice model detected level autophagy‐related proteins. Then, H19 content after...
Accumulating evidence indicates that lncRNAs are potential biomarkers and key regulators of tumor development progression. The present study aimed to screen abnormal expression investigate the mechanisms underlying function in progression colorectal cancer (CRC). Potential CRC prognosis-associated dysregulated were screened identified using bioinformatics analysis. Loss/gain-of-function experiments performed detect biological roles FAM222A-AS1 cell phenotypes vitro vivo. microRNAs interact...
Abstract To investigate the regulation of epidermal growth factor (EGF) by autophagy‐mediated long non‐coding RNA (lncRNA) H19 in intestinal tracts severely burned mice. C57BL/6J mice received third‐degree burns to 30% total body surface area. Rapamycin and 3‐methyladenine (3‐MA) were used activate inhibit autophagy, changes LC3 Beclin1 levels assessed Western blotting. The effect autophagy on lncRNA was detected qRT‐PCR. Adenovirus‐mediated overexpression IEC‐6 cells assess effects EGF...
Purpose: To demonstrate the effect of resveratrol on Notch signaling in MG-63 and U2OS osteosarcoma cell lines.Methods: Cell Counting Kit 8 reagent was used to analyze proliferation while TRIzol® employed for extraction total RNA. High Capacity cDNA reverse transcription chain reaction kit transcribe 2 μg Western blot analysis performed examine Hes1 Hey1 expression.Results: The results revealed that treatment exhibited dual mechanisms action activation cells. lines, U2OS, when exposed 20 μM...
<h3>Background</h3> Natural killer (NK) cells are crucial for eliminating tumor and virally-infected by integrating signals from activating inhibitory receptors. While NK-cell therapy has shown success in treating leukemias lymphomas, its effectiveness against solid tumors remains limited due to tumor-mediated suppression. Oncolytic viruses, which selectively target kill while enhancing antitumor immunity, offer a promising approach overcoming this Our study aims elucidate the mechanisms...
Background: To explore the expression level of miR-664-3p in osteosarcoma and its effects on proliferation apoptosis cells. Methods: Specimens tissues were collected from 41 cases undergoing surgical treatment Orthopedics Department Wuhan Puai Hospital, Wuhan, China January 2015 to February 2018. Another 40 normal bone tissue collected. The detected using quantificational real-time polymerase chain reaction. mimics, inhibitor miR-664- 3p negative control (NC) used transfect U2-OS, which...
Emerging evidence has demonstrated that cancer stem cells (CSCs) are involved in tumorigenesis, tumor recurrence and therapy resistance hepatocellular carcinoma (HCC). However, the mechanisms underlying regulation of CSCs HCC remain largely unknown. Here, we report protein tyrosine kinase 2 (PTK2) expression correlates with liver CSC marker expression, overall survival recurrence-free patients. PTK2 an activating effect on Wnt/β-catenin signaling caused by promotion nuclear accumulation...