A5030856434- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Cardiac Arrhythmias and Treatments
- Microfluidic and Capillary Electrophoresis Applications
- Cardiac pacing and defibrillation studies
- Immune cells in cancer
- Cardiac electrophysiology and arrhythmias
- Pancreatic function and diabetes
- Virus-based gene therapy research
- Innovation and Knowledge Management
- T-cell and B-cell Immunology
- Cardiac Imaging and Diagnostics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Ion channel regulation and function
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Membrane Separation Technologies
- Phagocytosis and Immune Regulation
- Biosensors and Analytical Detection
- Knowledge Management and Sharing
- ECG Monitoring and Analysis
- Cancer Cells and Metastasis
- Platelet Disorders and Treatments
The University of Texas MD Anderson Cancer Center
2020-2024
Houston Methodist
2007-2019
Methodist Hospital
2007
Glioblastoma multiforme (GBM), the most aggressive brain cancer, recurs because glioblastoma stem cells (GSCs) are resistant to all standard therapies. We showed that GSCs, but not normal astrocytes, sensitive lysis by healthy allogeneic natural killer (NK) in vitro. Mass cytometry and single-cell RNA sequencing of primary tumor samples revealed GBM tumor-infiltrating NK acquired an altered phenotype associated with impaired lytic function relative matched peripheral blood from patients or...
An implantable nanofluidic device for remote controlled drug delivery.
Myelodysplastic syndrome and acute myeloid leukemia (AML) belong to a continuous disease spectrum of malignancies with poor prognosis in the relapsed/refractory setting necessitating novel therapies. Natural killer (NK) cells from patients display global dysfunction impaired killing capacity, altered metabolism, an exhausted phenotype at single-cell transcriptomic proteomic levels. In this study, we identified that was mediated through cross-talk between NK blasts cell-cell contact. cell...
Acute graft-vs.-host (GVHD) disease remains a common complication of allogeneic stem cell transplantation with very poor outcomes once the becomes steroid refractory. Mesenchymal cells (MSCs) represent promising therapeutic approach for treatment GVHD, but so far this strategy has had equivocal clinical efficacy. Therapies using MSCs require optimization taking advantage plasticity these in response to different microenvironments. In study, we aimed optimize cord blood tissue derived (CBti...
Multiple imaging modalities are employed independent of one another while managing complex cardiac arrhythmias. To combine electrical, anatomical, and functional in a single catheter system, we developed balloon that carried 64 electrodes on its surface an intracardiac echocardiography (ICE) through central lumen. The system was inserted, the inflated inside left ventricle (LV) eight dogs with 6-wk-old infarction, created by occlusion anterior descending coronary artery. Anatomy constructed...
ABSTRACT Glioblastoma, the most aggressive brain cancer, often recurs because glioblastoma stem cells (GSCs) are resistant to all standard therapies. Here, we show that patient-derived GSCs, but not normal astrocytes, highly sensitive lysis by healthy allogeneic natural killer (NK) in vitro . In contrast, single cell analysis of autologous, tissue infiltrating NK isolated from surgical samples high-grade patient tumors using mass cytometry and RNA sequencing revealed an abnormal phenotype...
<h3>Background</h3> Natural killer (NK) cells are crucial for eliminating tumor and virally-infected by integrating signals from activating inhibitory receptors. While NK-cell therapy has shown success in treating leukemias lymphomas, its effectiveness against solid tumors remains limited due to tumor-mediated suppression. Oncolytic viruses, which selectively target kill while enhancing antitumor immunity, offer a promising approach overcoming this Our study aims elucidate the mechanisms...
The current global platelet supply is often insufficient to meet all the transfusion needs of patients, in particular for those with alloimmune thrombocytopenia. To address this issue, we have developed a strategy employing combination approaches achieve more efficient production functional megakaryocytes (MKs) and platelets collected from cord blood (CB)-derived CD34+ hematopoietic cells. This based on ex-vivo expansion differentiation MKs presence bone marrow niche-mimicking mesenchymal...
You have accessJournal of UrologyModerated Poster 25, Monday, May 21, 2007, 1:00 - 3:00 pm1 Apr 2007885: Combination Treatment Fiber-Modified Adenovirus Based HSV-1 Thymidine Kinase/Ganciclovir Gene Therapy with Docetaxel for Bladder Cancer Hideyuki Yamashita, Weigo Jian, April Gilbert, and Seth P. Lerner YamashitaHideyuki Yamashita More articles by this author , JianWeigo Jian GilbertApril Gilbert LernerSeth View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31113-3AboutPDF...
Introduction: Inter and Intra-ventricular dyssynchrony can develop during congestive heart failure (CHF). We investigated transmural electrical conduction properties within the LV wall CHF subsequent recovery. Methods: Biventricular pacemakers were implanted in 8 normal mongrel dogs (mean weight: 38 kg), continuous RV pacing (230 –250 bpm) was initiated to induce CHF. Echocardiography, catheterization, myocardial biopsy performed biweekly while temporarily stopped. At each an intracardiac...
Background : LV twist may reflect contractility under different conditions. This study investigated dynamics and its determinants in a canine model of congestive heart failure (CHF). Methods Pacemakers percutaneous leads were implanted 8 adult hound dogs (mean weight, 38 kg), continuous chronic RV pacing was applied at 230–250 bpm until CHF induction. Subsequently, turned off to allow the recover. Echocardiography catheterization performed simultaneously baseline, during while temporarily...
Abstract Conventional systemic immunotherapy administration often results in insufficient anti-tumor immune response and adverse side effects. Delivering immunotherapeutics intratumorally could maximize tumor exposure, elicit robust response, minimize toxicity. To fulfill the unmet clinical need for sustained local drug delivery to avoid repeated intratumoral injections, we developed a nanofluidic-based device called nanofluidic drug-eluting seed (NDES). The NDES is inserted using minimally...