A5087739307- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Cervical Cancer and HPV Research
- T-cell and B-cell Immunology
- Gut microbiota and health
- vaccines and immunoinformatics approaches
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Neuroblastoma Research and Treatments
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Immune Response and Inflammation
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Reproductive tract infections research
- Reproductive System and Pregnancy
- RNA Interference and Gene Delivery
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Immune cells in cancer
- Herpesvirus Infections and Treatments
- Hepatitis B Virus Studies
- Parasites and Host Interactions
The University of Texas MD Anderson Cancer Center
2016-2025
The University of Texas Health Science Center at Houston
2015-2024
Anderson University - South Carolina
2018
Baylor College of Medicine
2017
University of Houston
2016-2017
The University of Texas at Austin
1998-2015
Institute of Neuroimmunology of the Slovak Academy of Sciences
2008-2009
The University of Texas Medical Branch at Galveston
1984-1987
Czech Academy of Sciences
1981-1982
Tumor microbiota can produce active metabolites that affect cancer and immune cell signaling, metabolism, proliferation. Here, we explore tumor gut microbiome features chemoradiation response in patients with cervical using a combined approach of deep sequencing, targeted bacterial culture, vitro assays. We identify an obligate L-lactate-producing lactic acid bacterium found tumors, Lactobacillus iners, is associated decreased survival patients, induces chemotherapy radiation resistance...
Recent evidence indicates that human cancer cells reactivate the expression of latent endogenous retroviral (HERV) proteins. However, extent to which patients mount de novo immune responses against expressed HERV elements is unclear. In this study, we determined HERV-K env in breast (BC) and whether both humoral cell-mediated immunity can be found BC patients. We protein 88% (n = 119) but not normal 76) tissues. ELISA screening assays detected significant titers anti-HERV-K IgG a large...
HIV-1 is a chronic disease managed by strictly adhering to daily antiretroviral therapy (ART). However, not all people living with have access ART, and those may adhere treatment regimens increasing viral load progression. Here, subcutaneous nanofluidic implant was used as long-acting (LA) drug delivery platform address these issues. The device loaded tenofovir alafenamide (TAF) implanted in treatment-naïve simian HIV (SHIV)-positive nonhuman primates (NHP) for month. We monitored...
Abstract Diversity of the gut microbiome is associated with higher response rates for cancer patients receiving immunotherapy but has not been investigated in radiation therapy. Additionally, current studies investigating and outcomes may have adjusted established risk factors. Here, we sought to determine if diversity composition was independently survival cervical chemoradiation. Our study demonstrates that microbiota a favorable compositional variation among correlated short term...
<h3>Background</h3> The US is experiencing an epidemic of HPV<sup>+</sup> oropharyngeal cancers (OPC), the rates and burden which now exceed that for cervical cancer. Immunotherapy targeting programmed death 1 (PD-1) on tumor-infiltrating lymphocytes and/or its ligand PD-L1 tumor cells, was effective in several has however, showed efficacy only less than 15% patients. <h3>Methods</h3> We used a preclinical oral model, mEER, consisting mouse tonsil derived epithelial cells expressing HPV-16...
Significance Nearly all cervical, anal, vulvar, and penile cancer up to half of oropharyngeal cancers are driven by the E6 E7 oncoproteins human papilloma virus (HPV). Therapeutic vaccination against these HPV proteins can slow disease progression in animal models patients, but is rarely curative. We demonstrate that coadministration agonist antibodies targeting T-cell costimulatory receptor 4-1BB an intranasal E6/E7 peptide vaccine promoted durable regression 100% animals bearing + TC-1...
The tat protein from human immunodeficiency virus type 1 (HIV-1) activates viral gene expression and is essential for HIV replication in vitro. It has also been shown that the product specifically inhibits antigen-induced proliferation of peripheral blood lymphocytes. In order to understand growth immunomodulatory roles HIV-1 tat, we have examined effect on tumor necrosis factors a B-lymphoblastoid cell line (Raji). We report here introduced into Raji cells by retroviral-mediated...
Current iterations of the hygiene hypothesis suggest an adaptive role for helminth parasites in shaping proper maturation immune system. However, aspects this are based on assumptions that may not fully account realities about human infections. Such include evidence causal associations between infections and asthma or inflammatory bowel disease as well fact remain widespread United States, especially among populations at greatest risk autoimmune diseases.
Pre-exposure prophylaxis (PrEP) using antiretroviral oral drugs is effective at preventing HIV transmission when individuals adhere to the dosing regimen. Tenofovir alafenamide (TAF) a potent drug, with numerous long-acting (LA) delivery systems under development improve PrEP adherence. However, none has undergone preventive efficacy assessment. Here we show that LA TAF novel subcutaneous nanofluidic implant (nTAF) confers partial protection from transmission. We demonstrate sustained...
With continued expansion of the coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), both antiviral drugs as well effective vaccines are desperately needed to treat patients at high risk life-threatening disease. Here, we present in vitro evidence for significant inhibition SARS-CoV-2 oleandrin and a defined extract N. oleander (designated PBI-06150). Using Vero cells, found that prophylactic (pre-infection) (as either pure compound or active...
Human papillomavirus (HPV)-driven cancers include head and neck squamous cell carcinoma cervical cancer represent approximately 5% of all cases worldwide. Standard-of-care chemotherapy, radiotherapy, immune checkpoint inhibitors (ICIs) are associated with adverse effects limited responses in patients HPV-driven cancers. The integration targeted therapies ICIs may improve outcomes. In a previous study, we demonstrated that Aurora kinase A (AURKA, A) lead to apoptosis human HPV-positive cells...
<p>Supplementary Figure S4. Gating strategy for flow cytometry analysis of PBMC.</p>
<p>Supplementary Figure S3. Kaplan-Meier curves for progression-free survival (PFS) and overall (OS) in phase 2 patients, stratified by PD-L1 CPS score.</p>
<p>Supplementary Figure S8. Changes in absolute lymphocyte count (ALC) from baseline to 6 weeks of therapy.</p>
<p>Supplementary Figure S7. Flow cytometry analyses of circulating lymphocyte subsets in patients with acquired resistance (AR, <i>n</i>=8) or <i>de novo</i> (DR, n=4) to prior anti-PD1 immunotherapy.</p>
<p>Supplementary Figure S5. Flow cytometric analysis of PBMCs isolated from blood samples collected at baseline the patients with PD or SD.</p>