A5062569366- Gut microbiota and health
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods in Clinical Trials
- Cervical Cancer and HPV Research
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Biomedical Ethics and Regulation
- Genetic factors in colorectal cancer
- Reproductive tract infections research
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Mycobacterium research and diagnosis
- Epigenetics and DNA Methylation
- Economic and Financial Impacts of Cancer
- Immunotherapy and Immune Responses
- Bone health and treatments
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Cancer survivorship and care
- Urinary Tract Infections Management
- Cancer Immunotherapy and Biomarkers
- Palliative Care and End-of-Life Issues
The University of Texas MD Anderson Cancer Center
2020-2024
The University of Texas Health Science Center at Houston
2022
ORCID
2021
Background Since the beginning of coronavirus disease 2019 (COVID-19) epidemic, misinformation has been spreading uninhibited over traditional and social media at a rapid pace. We sought to analyze magnitude that is being spread on Twitter (Twitter, Inc., San Francisco, CA) regarding epidemic. Materials methods conducted search using 14 different trending hashtags keywords related COVID-19 then summarized assessed individual tweets for in comparison verified peer-reviewed resources....
Tumor microbiota can produce active metabolites that affect cancer and immune cell signaling, metabolism, proliferation. Here, we explore tumor gut microbiome features chemoradiation response in patients with cervical using a combined approach of deep sequencing, targeted bacterial culture, vitro assays. We identify an obligate L-lactate-producing lactic acid bacterium found tumors, Lactobacillus iners, is associated decreased survival patients, induces chemotherapy radiation resistance...
Abstract Diversity of the gut microbiome is associated with higher response rates for cancer patients receiving immunotherapy but has not been investigated in radiation therapy. Additionally, current studies investigating and outcomes may have adjusted established risk factors. Here, we sought to determine if diversity composition was independently survival cervical chemoradiation. Our study demonstrates that microbiota a favorable compositional variation among correlated short term...
Background Squamous cell carcinoma of the anus (SCCA) is a rare gastrointestinal cancer. Factors associated with progression HPV infection to anal dysplasia and cancer are unclear screening guidelines approaches for less clear than cervical dysplasia. One potential contributing factor anorectal microbiome. In this study, we aimed identify differences in microbiome composition settings infection, dysplasia, disease. Methods Patients were enrolled two prospective studies. part cross-sectional...
Although high-risk human papillomavirus infection is a well-established risk factor for cervical cancer, other co-factors within the local microenvironment may play an important role in development of cancer. The current study aimed to characterize cervicovaginal microbiota women with premalignant dysplasia or invasive cancer compared that healthy women. comprised 120 Ethiopian (60 patients who had not received any treatment, 25 dysplasia, and 35 women). Cervicovaginal specimens were...
Survival analyses of novel agents with long-term responders often exhibit differential hazard rates over time. Such proportional hazards violations (PHV) may reduce the power log-rank test and lead to misinterpretation trial results. We aimed characterize incidence study attributes associated PHVs in phase III oncology trials assess utility restricted mean survival time maximum combination as additional analyses.
Statistical significance currently defines superiority in phase III oncology trials. However, this practice is increasingly questioned. Here, we estimated the fragility of Using Kaplan-Meier curves for primary endpoints 230 two-arm trials, reconstructed data individual patients. We survival-inferred index (SIFI) by iteratively flipping best responder from experimental arm to control (SIFI B ) until interpretation was changed according threshold each trial. Severe defined SIFI ≤ 1%. This...
Background A diverse and abundant gut microbiome can improve cancer patients’ treatment response; however, the effect of pelvic chemoradiotherapy (CRT) on diversity composition is unclear. The purpose this prospective study was to identify changes in during after CRT. Materials methods Rectal swabs from 58 women with cervical, vaginal, or vulvar two institutions were prospectively analyzed before CRT (baseline), (weeks 1, 3, 5), at first follow-up (week 12) using 16Sv4 rRNA gene sequencing...
Patients with localized squamous cell carcinoma of the anus (SCCA) who experience treatment toxicity or recurrences have few therapeutic options. Investigation into microbiome's influence on and its potential use as a predictive biomarker could improve these patients' outcomes. Our study presents first longitudinal characterization SCCA tumor microbiome associations treatment-related toxicities.This prospective cohort included patients nonmetastatic receiving standard-of-care chemoradiation...
This economic evaluation estimates the out-of-pocket cost savings patients could achieve if generic drugs were purchased directly from Mark Cuban Cost Plus Drug Company rather than using their health insurance.
Gut microbiome community composition differs between cervical cancer (CC) patients and healthy controls, increased gut diversity is associated with improved outcomes after treatment. We proposed that functions of specific microbial species adjoining the mucus layer may directly impact biology CC.Metagenomes rectal swabs in 41 CC were examined by whole-genome shotgun sequencing to link taxonomic structures, molecular functions, metabolic pathway patient's clinical characteristics.Significant...
Abstract Differential censoring, which refers to censoring imbalance between treatment arms, may bias the interpretation of survival outcomes in clinical trials. In 146 phase III oncology trials with statistically significant time-to-event surrogate primary endpoints, we evaluated association differential control arm adequacy, and subsequent statistical significance overall results. Twenty-four (16%) exhibited that favored arm, whereas 15 (10%) experimental arm. Positive was more common...
Among patients with anal cancer, chemoradiotherapy is often associated toxicities that diminish quality of life. We describe the GI-related patient-reported outcomes (PROs) cancer receiving to improve patient-physician communication.We prospectively followed nonmetastatic squamous cell carcinoma canal who received definitive chemoradiotherapy. Patients completed bowel subdomain Expanded Prostate Cancer Index Composite (EPIC) questionnaire before treatment and at 4 subsequent timepoints. used...
We evaluated the association of disease outcome with T cell immune-related characteristics and receptor (TCR) repertoire in malignant ascites from patients high-grade epithelial ovarian cancer. Ascitic fluid samples were collected 47 cancer analyzed using flow cytometry TCR sequencing to characterize complementarity determining region 3 β-chain. functions McPAS-TCR VDJ databases. clustering was implemented Grouping Lymphocyte Interactions by Paratope Hotspots software. Patients poor...
Introduction We characterized the cervical 16S rDNA microbiome of patients in Botswana with high-grade dysplasia and locally advanced cancer. Methods This prospective study included 31 patients: 21 10 The Shannon diversity index was used to evaluate alpha (intra-sample) diversity, while UniFrac (weighted unweighted) Bray–Curtis distances were employed beta (inter-sample) diversity. relative abundance microbial taxa compared among samples using linear discriminant analysis effect size....
1561 Background: Hazard ratio (HR)-based analyses used in oncology trials rely on the assumption of proportional hazards, i.e. a HR that is constant over time. Proportional hazards violations (PHVs) may lead to misinterpretation trial results. Restricted mean survival time (RMST) valid with non-proportional and has received recent attention specifically for immunotherapy (IO) but not been routinely adopted design as whole. We aimed comprehensively characterize incidence factors associated...
Objectives This study investigates retreatment rates in single-fraction radiation therapy (SFRT) for painful bone metastasis patients with limited life expectancy. We compared retreatment-free survival (RFS) from a rapid access metastases clinic (RABC) and non-RABC patients, identifying factors associated retreatment. Methods In this observational study, we analysed RABC who received SFRT between April 2018 November 2019, using as comparison group. Patients prior or perioperative (RT) were...
Abstract Objective Cervical cancer is a leading cause of cancer-related deaths in women worldwide, to over 340,000 2022. The majority cervical cancers are caused by the persistent infection high-risk human papillomavirus (HPV). In United States, Hispanic at increased risk development and more likely die disease certain geographical locations. Furthermore, prior research implicated an association between vaginal microbiota HPV dysplasia. This descriptive study aims explore microbiome profiles...