A5015321100- Gut microbiota and health
- Cervical Cancer and HPV Research
- Algal biology and biofuel production
- Reproductive tract infections research
- Colorectal Cancer Screening and Detection
- Wastewater Treatment and Nitrogen Removal
- Anaerobic Digestion and Biogas Production
- Per- and polyfluoroalkyl substances research
- Odor and Emission Control Technologies
- Fluoride Effects and Removal
- Cancer survivorship and care
- Reproductive System and Pregnancy
- Mycobacterium research and diagnosis
- Microbial bioremediation and biosurfactants
- Toxic Organic Pollutants Impact
- Biofuel production and bioconversion
- Colorectal and Anal Carcinomas
- Pharmaceutical and Antibiotic Environmental Impacts
- Biodiesel Production and Applications
- Industrial Gas Emission Control
- Soil Carbon and Nitrogen Dynamics
- Urinary Tract Infections Management
- Wastewater Treatment and Reuse
- Microbial Fuel Cells and Bioremediation
- HIV Research and Treatment
Baylor College of Medicine
2019-2024
The University of Texas Health Science Center at Houston
2017
Universidade do Oeste de Santa Catarina
2015-2016
University of the West
2014-2016
University of Iowa
2004-2015
Universidade Federal de Santa Catarina
2011-2014
Agricultural Research Corporation
2013
Brazilian Agricultural Research Corporation
2013
Rice University
2006
University of Chemistry and Technology, Prague
2005
Murine studies showed that disruption of circadian clock rhythmicity could lead to cancer and metabolic syndrome. Time-restricted feeding can reset the disrupted rhythm, protect against Based on these observations, we hypothesized intermittent fasting for several consecutive days without calorie restriction in humans would induce an anticarcinogenic proteome key regulatory proteins glucose lipid metabolism. Fourteen healthy subjects fasted from dawn sunset over 14 h daily. Fasting duration...
Abstract Diversity of the gut microbiome is associated with higher response rates for cancer patients receiving immunotherapy but has not been investigated in radiation therapy. Additionally, current studies investigating and outcomes may have adjusted established risk factors. Here, we sought to determine if diversity composition was independently survival cervical chemoradiation. Our study demonstrates that microbiota a favorable compositional variation among correlated short term...
This work evaluated N dynamics that occurs over time within swine slurry composting piles. Real-time quantitative PCR (qPCR) analyzes were conducted to estimate concentrations of bacteria community harboring specific catabolic nitrifying-ammonium monooxygenase (amoA), and denitrifying nitrate- (narG), nitrite- (nirS nirG), nitric oxide- (norB) nitrous oxide reductases (nosZ) genes. NH3-N, N2O-N, N2-N emissions represented 15.4 ± 1.9%, 5.4 0.9%, 79.1 2.0% the total nitrogen losses,...
BACKGROUND Aerobic granular sludge (AGS) technology has been widely investigated for wastewater treatment. The morphological and structural characteristics of granules nitrogen pathways have not fully clarified using real domestic wastewater. To address this issue, microbial community distribution, diversity functional towards conversions in a sequencing batch reactor were investigated. RESULTS Granules (d ∼ 300 µm) formed with low-strength (COD influent < 200 mg CODsoluble L−1). COD...
Both the host microbiome and of built environment can have profound influences on human health. While prior studies suggested that variability introduced by DNA extraction method is less than typical biologic variation, most focused 16S rRNA amplicon sequencing or high biomass fecal samples. Shotgun metagenomic provides advantages over for surveying but a challenge to perform in lower microbial samples with content such as sputum vacuumed dust. Here we systematically evaluate impact four...
The environmental fate of per- and polyfluoroalkyl substances (PFAS) in aqueous film-forming foams (AFFFs) remains largely unknown, especially under the conditions representative natural subsurface systems. In this study, biotransformation 8:2 fluorotelomer alcohol (8:2 FTOH), a component new-generation AFFF formulations byproduct fluorotelomer-based AFFFs, was investigated nitrate-, iron-, sulfate-reducing microcosms prepared with AFFF-impacted soils. Liquid chromatography–tandem mass...
Microbial transformation of per- and polyfluoroalkyl substances (PFAS), including fluorotelomer-derived PFAS, by native microbial communities in the environment has been widely documented. However, few studies have identified key microorganisms their roles during PFAS biotransformation processes. This study was undertaken to gain more insight into structure function soil that are relevant biotransformation. We collected 16S rRNA gene sequencing data from 8:2 fluorotelomer alcohol 6:2...
Background Squamous cell carcinoma of the anus (SCCA) is a rare gastrointestinal cancer. Factors associated with progression HPV infection to anal dysplasia and cancer are unclear screening guidelines approaches for less clear than cervical dysplasia. One potential contributing factor anorectal microbiome. In this study, we aimed identify differences in microbiome composition settings infection, dysplasia, disease. Methods Patients were enrolled two prospective studies. part cross-sectional...
Although high-risk human papillomavirus infection is a well-established risk factor for cervical cancer, other co-factors within the local microenvironment may play an important role in development of cancer. The current study aimed to characterize cervicovaginal microbiota women with premalignant dysplasia or invasive cancer compared that healthy women. comprised 120 Ethiopian (60 patients who had not received any treatment, 25 dysplasia, and 35 women). Cervicovaginal specimens were...
Abstract Understanding the function of detoxifying enzymes in plants toward xenobiotics is major importance for phytoremediation applications. In this work, Arabidopsis (Arabidopsis thaliana; ecotype Columbia) seedlings were exposed to 0.6 mm acetochlor (AOC), 2 metolachlor (MOC), 2,4,6-trinitrotoluene (TNT), and 0.3 hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). vivo glutathione (GSH) conjugation reactions AOC, MOC, RDX, TNT studied root cells using a multiphoton microscope. situ labeling...
Background A diverse and abundant gut microbiome can improve cancer patients’ treatment response; however, the effect of pelvic chemoradiotherapy (CRT) on diversity composition is unclear. The purpose this prospective study was to identify changes in during after CRT. Materials methods Rectal swabs from 58 women with cervical, vaginal, or vulvar two institutions were prospectively analyzed before CRT (baseline), (weeks 1, 3, 5), at first follow-up (week 12) using 16Sv4 rRNA gene sequencing...
This study investigated the interactions between naturally occurring bacteria and microalgae Chlorella vulgaris within a lab scale photobioreactor treating ammonia-rich swine wastewater digestate effluent. Nitrification denitrification were assessed by targeting ammonia monoxygenases (amoA), nitrate (narG), nitrite (nirS), nitric oxide (norB) nitrous (nosZ) reductases genes. Oxygen produced from photosynthesis stimulated nitrification. Under limiting carbon availability (i.e., <1.44 for mg...
This study investigated the efficiency of an organic tannin polymer alone or amended with polyacrylamide to harvest Chlorella vulgaris biomass grown in a laboratory-scale photobioreactor treating swine wastewater digestate. The effect concentration, (TAN) dosages and changes pH were evaluated jar test experiments. Among TAN concentrations tested (11, 22, 44, 89, 178 mg L−1), 11 L−1 showed highest recovery (97%). coagulation/ flocculation efficiencies obtained at 5 7. Flocculation improved...
Patients with localized squamous cell carcinoma of the anus (SCCA) who experience treatment toxicity or recurrences have few therapeutic options. Investigation into microbiome's influence on and its potential use as a predictive biomarker could improve these patients' outcomes. Our study presents first longitudinal characterization SCCA tumor microbiome associations treatment-related toxicities.This prospective cohort included patients nonmetastatic receiving standard-of-care chemoradiation...