A5103153582- Cervical Cancer and HPV Research
- Gut microbiota and health
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Circadian rhythm and melatonin
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Neuroscience of respiration and sleep
- Colorectal Cancer Screening and Detection
- Sleep and Wakefulness Research
- Endometrial and Cervical Cancer Treatments
- Cancer survivorship and care
- Molecular Biology Techniques and Applications
- Neuroendocrine regulation and behavior
- Genetic factors in colorectal cancer
- Adipose Tissue and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Head and Neck Cancer Studies
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Mycobacterium research and diagnosis
- Craniofacial Disorders and Treatments
- Neural dynamics and brain function
- Ovarian cancer diagnosis and treatment
- Thermoregulation and physiological responses
The University of Texas MD Anderson Cancer Center
2019-2024
Kameda Medical Center
2023
Mie University
2005-2022
The University of Texas Health Science Center at Houston
2022
The University of Tokyo
2009-2016
RIKEN Center for Brain Science
2011-2016
Japan Community Healthcare Organization
2016
Beth Israel Deaconess Medical Center
2005-2015
Tokyo Dental College
1996-2015
Osaka University
1992-2013
Abstract Emotions, stress, hunger, and circadian rhythms all promote wakefulness behavioral arousal. Little is known about the pathways mediating these influences, but orexin‐producing neurons of hypothalamus may play an essential role. These cells heavily innervate many wake‐promoting brain regions, mice lacking orexin have narcolepsy fail to rouse in response hunger (Yamanaka et al. [ 2003 ] Neuron 38:701–713). To identify afferents neurons, we first injected a retrograde tracer into...
Tumor microbiota can produce active metabolites that affect cancer and immune cell signaling, metabolism, proliferation. Here, we explore tumor gut microbiome features chemoradiation response in patients with cervical using a combined approach of deep sequencing, targeted bacterial culture, vitro assays. We identify an obligate L-lactate-producing lactic acid bacterium found tumors, Lactobacillus iners, is associated decreased survival patients, induces chemotherapy radiation resistance...
Sympathetic premotor neurons in the rostral medullary raphe (RMR) regulate heat conservation by tail artery vasoconstriction and brown adipose tissue thermogenesis. These are a critical relay pathway that increases body temperature. However, origins of inputs activate RMR during cold exposure have not been definitively identified. We investigated afferents to were activated examining Fos expression retrogradely labeled after injection cholera toxin B subunit (CTb) RMR. experiments identified...
Abstract Diversity of the gut microbiome is associated with higher response rates for cancer patients receiving immunotherapy but has not been investigated in radiation therapy. Additionally, current studies investigating and outcomes may have adjusted established risk factors. Here, we sought to determine if diversity composition was independently survival cervical chemoradiation. Our study demonstrates that microbiota a favorable compositional variation among correlated short term...
Atypical neurodevelopment in autism spectrum disorder is a mystery, defying explanation despite increasing attention. We report on Japanese macaque that spontaneously exhibited autistic traits, namely, impaired social ability as well restricted and repetitive behaviors, along with our single-neuron genomic analyses. Its was measured turn-taking task, where two monkeys monitor each other's actions for adaptive behavioral planning. In its brain, the medial frontal neurons responding to others'...
Although high-risk human papillomavirus infection is a well-established risk factor for cervical cancer, other co-factors within the local microenvironment may play an important role in development of cancer. The current study aimed to characterize cervicovaginal microbiota women with premalignant dysplasia or invasive cancer compared that healthy women. comprised 120 Ethiopian (60 patients who had not received any treatment, 25 dysplasia, and 35 women). Cervicovaginal specimens were...
<p>Supplementary Figures and Tables</p>
<div>AbstractPurpose:<p>Human papillomavirus (HPV) is a significant cause of cervical cancer. We hypothesized that detecting viral cell-free HPV DNA (cfDNA) before, during, and after chemoradiation (chemoRT) could provide insights into disease extent, clinical staging, treatment response.</p>Experimental Design:<p>A total 66 patients with locally advanced cancer were enrolled between 2017 2023, 49 receiving standard-of-care 17 participating in trial combining...
<p>Supplementary Figures and Tables</p>
Abstract The major effector organ for thermogenesis during inflammation or experimental pyrogen‐induced fever in rodents is the brown adipose tissue (BAT). Prostaglandin E2 (PGE 2 ) microinjection into medial preoptic area (POA) of rats leads to hyperthermia through an increase BAT and induces pyrogenic signal transmission towards raphe pallidus nucleus (RPa), a brainstem known contain sympathetic premotor neurons control. POA has high expression prostaglandin E receptor subtype EP3 (EP3R)...
Background A diverse and abundant gut microbiome can improve cancer patients’ treatment response; however, the effect of pelvic chemoradiotherapy (CRT) on diversity composition is unclear. The purpose this prospective study was to identify changes in during after CRT. Materials methods Rectal swabs from 58 women with cervical, vaginal, or vulvar two institutions were prospectively analyzed before CRT (baseline), (weeks 1, 3, 5), at first follow-up (week 12) using 16Sv4 rRNA gene sequencing...
Homeothermic animals regulate body temperature (T b ) by using both autonomic and behavioral mechanisms. In the latter process, seek out cooler or warmer places when they are exposed to excessively hot cold environments. Thermoregulation is affected state of energy reserves in body. present study, we examine effects 4-day food deprivation on circadian changes T cold-escape heat-escape behaviors rats. Continuous measurement during indicated that peak amplitude was not different from baseline...
Abstract Ovarian cancer is associated with a high mortality rate due to diagnosis at advanced stages. Dissemination often occurs intraperitoneally within the ascites fluid. The microenvironment can support dissemination through several mechanisms. One potential factor which may mediate are EVs or extracellular vesicles that carry information in form of miRNAs, proteins, lipids, and act as mediators cellular communication. We present our observations on isolated from ascitic supernatants...
Due to the lack of correlation between symptom severity and electrophysiology or nerve function, 'container hypothesis' has emerged as a new concept in carpal tunnel syndrome (CTS). This proposes that symptoms relate connective tissue alteration rather than fibre pathology. study was conducted investigate pathology flexor tenosynovium its relationship with symptomatology. The subjects comprised 40 patients electrophysiologically proven CTS who underwent open release (age range: 31–79 years)....
Systemic inflammatory response syndrome is associated with either fever or hypothermia, but the mechanisms responsible for switching from one to other are unknown. In experimental animals, systemic inflammation often induced by bacterial lipopolysaccharide (LPS). To identify diencephalic and brainstem structures involved in fever-hypothermia switch, we studied expression of c-Fos protein, a marker neuronal activation, rats treated same high dose LPS (0.5 mg/kg, intravenously) thermoneutral...
Cytokeratins (CK) are abundant in keratinized cells, particularly CK14 and CK19, which expressed stratified squamous epithelial cells. In this study, expression of 19 was examined human dysplastic tissues. Surgical specimens from patients with clinically diagnosed oral leukoplakia or early cancer were stained hematoxylin eosin classified into normal, low grade dysplasia (LGD), high (HGD), cell carcinoma (SCC). The sections by immunostaining reverse transcription-polymerase chain reaction...