A5101630152- Mosquito-borne diseases and control
- Malaria Research and Control
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- HIV, Drug Use, Sexual Risk
- Viral-associated cancers and disorders
- Hepatitis B Virus Studies
- Archaeological and Historical Studies
- Liver Disease Diagnosis and Treatment
- Venomous Animal Envenomation and Studies
- HIV Research and Treatment
- Vector-borne infectious diseases
- Herpesvirus Infections and Treatments
- Vector-Borne Animal Diseases
- Trypanosoma species research and implications
- Viral Infections and Outbreaks Research
- SARS-CoV-2 detection and testing
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- Parasitic infections in humans and animals
- Health Promotion and Cardiovascular Prevention
The University of Texas Medical Branch at Galveston
2020-2025
Universidad de Antioquia
2011-2024
Sir Charles Gairdner Hospital
2024
Maastricht University
2023
Primary Health Care
2019-2020
United States Army Medical Research Institute of Infectious Diseases
2020
University of Pittsburgh
2020
National Institute of Allergy and Infectious Diseases
2020
National Institutes of Health
2020
Tulane University
2020
We aerosolized severe acute respiratory syndrome coronavirus 2 and determined that its dynamic aerosol efficiency surpassed those of Middle East syndrome. Although we performed experiment only once across several laboratories, our findings suggest retained infectivity virion integrity for up to 16 hours in respirable-sized aerosols.
Brazil is a unique and understudied setting for malaria, with complex foci of transmission associated human environmental conditions. An understanding the population genomic diversity
Despite the high burden of Plasmodium vivax malaria in South Asian countries, genetic diversity circulating parasite populations is not well described. Determinants antimalarial drug susceptibility for P. region have been characterised. Our genomic analysis global (n = 558) establishes isolates 92) as a distinct subpopulation, which shares ancestry with some East African and parasites. Signals positive selection are linked to resistance-associated loci including pvkelch10, pvmrp1, pvdhfr...
With continued expansion of the coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), both antiviral drugs as well effective vaccines are desperately needed to treat patients at high risk life-threatening disease. Here, we present in vitro evidence for significant inhibition SARS-CoV-2 oleandrin and a defined extract N. oleander (designated PBI-06150). Using Vero cells, found that prophylactic (pre-infection) (as either pure compound or active...
Background: The tick-borne pathogens, Bourbon virus (BRBV) and Heartland (HRTV) are the cause of febrile illnesses that may progress to severe fatal diseases. Materials Methods: As a preliminary effort determine if these viruses were enzootic in Texas, ticks blood samples collected from feral swine (Sus scrofa) white-tailed deer (Odocoileus virginianus) (WTD) killed by gunning as part an abatement program during 2019-2021 Travis County, Texas. Ticks animals hand obtained cardiac puncture...
There is a scarcity of information about patients with mild or moderate symptoms during the coronavirus disease 2019 (COVID-19). This especially true for those who attended and were followed up at primary care settings.
ABSTRACT With continued expansion of the COVID-19 pandemic, antiviral drugs are desperately needed to treat patients at high risk life-threatening disease and even limit spread if administered early during infection. Typically, fastest route identifying licensing a safe effective drug is test those already shown in clinical trials for other infections or diseases. Here, we tested vitro oleandrin, derived from Nerium oleander plant previously have inhibitory activity against several viruses....
ABSTRACT Background During the coronavirus disease 2019 (COVID-19) pandemic little information has been available about patients with mild or moderate symptoms attended and followed in primary care setting, most of whom had an unknown status for severe acute respiratory syndrome 2 (SARS-CoV-2) infection. Objectives We aim to measure seroprevalence antibodies against SARS-CoV-2 infection a community sample asymptomatic individuals among symptomatic (without confirmed diagnosis) setting. As...
Several arboviruses have emerged or reemerged into the New World during past several decades, causing outbreaks of significant proportion. In particular, Dengue virus (DENV), Zika virus, and Chikungunya (CHIKV) been explosive unpredictable, led to adverse health effects. These viruses are considered leading cause acute undifferentiated febrile illnesses in Colombia. However, Venezuelan equine encephalitis (VEEV) is endemic Colombia, such as Mayaro (MAYV) Oropouche (OROV) neighboring...
Introducción. La malaria representa un problema de salud pública en la región Urabá, donde se registran tasas superiores a las del departamento Antioquia; carga por Plasmodium vivax es 78,7 % y poco ha explorado su perfil región.Objetivos. Con el presente estudio pretende conocer características clínicas laboratorio los pacientes hospitalizados P. Apartadó.Materiales métodos. Se revisaron historias con que requirieron manejo hospitalario Hospital “Antonio Roldán Betancur”, Empresa Social...
Malaria is a public health problem in the Urabá region recording rates of infection above those Antioquia department. The burden vivax malaria 78.7% and profile this has scarcely been studied.To analyze clinical laboratory characteristics patients hospitalized for Apartadó.We reviewed medical records with Antonio Roldán Betancur hospital from 2004-2007. Results. Of 359 who required hospitalization, 23.1% (83/359 patients) had following complications: severe anemia, 51.8% (43/83);...
Rickettsiae are obligate intracellular Gram-negative bacteria that the causative agent of rickettsioses and spread to vertebrate hosts by arthropods. There no previous reports isolation Rickettsia amblyommatis for Colombia.A convenience sampling was executed in three departments Colombia direct collection adult ticks on domestic animals or over vegetation. Ticks were screened presence spp. real-time polymerase chain reaction (qPCR) amplifying citrate synthase gene (gltA), positive sample...
ABSTRACT. On August 30, 2017, one of five bontebok in a mixed-species exhibit at the Nashville Zoo Grassmere exhibited acute hind-limb ataxia and altered demeanor. Pathological examination demonstrated meningoencephalitis spinal myelitis. Coinfection West Nile virus (WNV) epizootic hemorrhagic disease (EHDV) was revealed by quantitative real-time traditional reverse transcription–polymerase chain reaction assays isolation/whole genome sequencing from brain tissue, respectively. Whole...
ABSTRACT The in vitro susceptibilities of 30 isolates Plasmodium vivax to a number antimalarials (chloroquine [CQ], mefloquine, amodiaquine, quinine, and artesunate [AS]) were evaluated. came from the region Urabá Colombia, which malaria is endemic, evaluated by schizont maturation test. 50% inhibitory concentration (IC 50 ) was 0.6 nM (95% confidence interval [CI], 0.3 1.0 nM) for artesunate, 8.5 CI, 5.6 13.0 23.3 12.4 44.1 chloroquine, 55.6 36.8 84.1 115.3 57.7 230.5 quinine. classified...
The first articulated remains of ophiuroids for the Mesozoic South America are described from Lower Cretaceous Neuquén Basin, Argentina. taxonomic analysis allows assignment material herein to extinct genus Ophiopetra. specimens belong a new species, but considering poor preservation, name is not introduced, as it would be based on an incomplete diagnosis. Certain characteristics (e.g., diameter disc, width/height ratio vertebrae) suggest that these paedomorphic specimens. In light latest...
ABSTRACT. Mayaro virus (MAYV) is an arthropod-borne (arbovirus) belonging to the family Togaviridae , genus Alphavirus . In recent years, geographic distribution of MAYV may have expanded north from South and Central America into Caribbean Islands. Although Haemagogus janthinomys considered main vector for MAYV, has also been isolated other mosquitoes, including Aedes aegypti a widespread species that serves as highly epidemic viruses. Given possible expansion outbreaks in Latin America, it...
The aim of this study was to evaluate the presence mutations and polymorphisms associated with drug resistance among HIV-1-infected patients in proviral DNA viral RNA extracted from PBMCs plasma, respectively, 34 (11 naive 23 receiving HAART). Additional were found only one compartment 14 treated patients. Mutations conferring an additional plasma 7 A greater number differences strains infected for at least more than 9 years, compared whom time since first diagnosis lower (p < 0.02). This...
Background . In order to prevent the spread of hepatitis C virus (HCV) amongst Hispanic injection drug users (IDUs), we developed, validated, and implemented a multimedia educational intervention program. Methods A pre-post study design was used evaluate long-lasting knowledge behavior changes in group 88 low-income HIV-infected IDUs. Pre-intervention data compared with measured six months after intervention. Results significant increase awareness regarding HCV clinical manifestations, risky...