A5065537299- Science Education and Pedagogy
- SARS-CoV-2 and COVID-19 Research
- Immune cells in cancer
- Experimental Learning in Engineering
- Mitochondrial Function and Pathology
- Innovative Teaching Methods
- COVID-19 Clinical Research Studies
- Education, Achievement, and Giftedness
- Neuroinflammation and Neurodegeneration Mechanisms
- Distributed and Parallel Computing Systems
- Immunotherapy and Immune Responses
- Mosquito-borne diseases and control
- Immune Response and Inflammation
- Mathematics Education and Teaching Techniques
- Lipid Membrane Structure and Behavior
- Solar and Space Plasma Dynamics
- Video Analysis and Summarization
- Gas Dynamics and Kinetic Theory
- Statistics Education and Methodologies
- Cellular Mechanics and Interactions
- Laser Design and Applications
- Infection Control and Ventilation
- Astrophysical Phenomena and Observations
- Essential Oils and Antimicrobial Activity
- Simulation-Based Education in Healthcare
Texas Biomedical Research Institute
2018-2024
University of Kansas
2019-2024
University of Chicago
2024
Cohen Children's Medical Center
2017
With continued expansion of the coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), both antiviral drugs as well effective vaccines are desperately needed to treat patients at high risk life-threatening disease. Here, we present in vitro evidence for significant inhibition SARS-CoV-2 oleandrin and a defined extract N. oleander (designated PBI-06150). Using Vero cells, found that prophylactic (pre-infection) (as either pure compound or active...
We used student surveys to assess changes in proficiency with integral calculus, calculus self-efficacy, and physics self-efficacy a second semester course of introductory focused on electricity magnetism. In addition tracking the fraction quantitative problems solved correctly survey, we also principal component analysis factor data collected using all three evaluate attitude. These analyses indicate that while students demonstrated an increase including integration context physics, women...
Abstract Mitochondrial dysfunction alters cellular metabolism, increases tissue oxidative stress, and may be principal to the dysregulated signaling function of CD4 + T lymphocytes in elderly. In this proof principle study, it is investigated whether transfer functional mitochondria into cells that are isolated from old mice (aged cells), can abrogate aging‐associated mitochondrial dysfunction, improve aged cell functionality. The results show delivery exogenous non‐activated led significant...
The innate immune system initiates early response to infection by sensing molecular patterns of through pattern-recognition receptors (PRRs). Previous work on PRR stimulation macrophages revealed significant heterogeneity in single cell responses, suggesting the importance individual macrophage stimulation. Current methods either isolate or stimulate a whole culture and measure readouts. We probed NF-κB responses localized stimuli within naïve with Fluidic Force Microscopy (FluidFM)....
Here we demonstrate the benefits of a new curriculum for introductory calculus-based physics that motivates classical mechanics using modified version Hamiltonian mechanics. This shifts initial focus instruction away from forces and associated vector mathematics, which are known to be problematic students, scalar quantity energy, is more closely aligned with their previously established intuition, differential integral calculus. We show implementation this calculus-enhanced "energy-first"...
Despite several vaccines that are currently approved for human use to control the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is an urgent medical need therapeutic and prophylactic options. SARS-CoV-2 binding entry in cells involves interactions of its spike (S) protein with host cell surface factors, including heparan sulfate proteoglycans (HSPGs), transmembrane protease serine (TMPRSS2), angiotensin-converting enzyme (ACE2). In this paper we...
Abstract Although the efficacy of vaccines targeting SARS-CoV-2 is apparent now that approved mRNA and adenovirus vector are in widespread use, longevity protective immune response its against emerging variants remains to be determined. We have therefore designed a DNA vaccine encoding both spike receptorbinding domain (‘RBD’) nucleocapsid proteins, latter which highly conserved amongst beta coronaviruses. The elicits strong pro-inflammatory CD4 + Th1 CD8 T-cell responses proteins mice rats,...
Here, we present a protocol to deliver nanoliter volumes of Toll-like receptor (TLR) agonist onto culture nuclear factor κB (NF-κB) reporter macrophages using fluidic force microscopy and micron-scale probe. We describe steps for quantifying the dose by modeling their diffusion with experimental inputs. then detail procedures categorizing macrophage responses individual varied doses combining concentration response analyze NF-κB localized TLR stimulation. For complete details on use...
Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation Jennifer Delgado; Less content is more in introductory astronomy. Phys. Teach. 1 January 2024; 62 (1): 70–71. https://doi.org/10.1119/5.0180883 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Dropdown Menu input auto suggest filter...
We assessed changes in calculus proficiency and self-efficacy a second semester course of introductory physics focused on electricity magnetism. While all students demonstrated an increase proficiency, including possible improvement transfer to physics, women displayed larger gains than men. Conversely, men showed self-efficacy. When combined, these data suggest that student identity modulates the correlation between student's abilities their perception or self-evaluation those abilities....
Understanding the protective principles that lead to a safe, effective vaccine against HIV in nonhuman primate (NHP) models requires test viruses allow evaluation of anti-HIV envelope responses. Reduced acquisition risk RV144 has been linked nonneutralizing IgG antibodies with range effector activities. Definitive experiments decipher mechanisms partial protection observed require passive-immunization studies NHPs relevant virus. We have generated such virus by inserting env from an placebo...
Nationally, social work students face limited access to clinical education that examines the intersection of older adults, chronic disease, and mental health. This is critical due a rapidly aging population shortage geriatrics trained workers. Scant data exists on effectiveness simulations prepare in health specialties. In this study, 118 MSW completed simulation through Standardized Patient (SP) Program consisting gerontology course, patient interview, debriefings, self-efficacy counseling...
We present a model for competency-based grading calculus-based introductory physics that encourages students to obtain proficiency with all course content. By allowing continually improve their skills and content throughout the semester, this formative system is designed create more flexible learning environment better accommodates varying schedules needs of students. While show improvement in performance following implementation system, largest gains were found women first generation...
Abstract Mitochondrial dysfunction alters cellular metabolism, increases tissue oxidative stress, and may be principal to the dysregulated signaling function of CD4 + T lymphocytes in elderly. In this proof principle study, we investigated whether transfer functional mitochondria into cells that were isolated from old mice (aged cells), could abrogate aging-associated mitochondrial dysfunction, improve aged cell functionality. Our results show delivery exogenous non-activated led significant...
We present our initial work to develop an assessment of calculus proficiency in the context introductory physics (i.e., transfer physics), including a comparison ability with self-efficacy and how these attributes intersect student gender. Although students demonstrated improvement their ability, most nevertheless displayed decrease self-efficacy. Similarly, while women consistently exhibited lower than men, larger gains physics. also discuss future better evaluate interdependence...