A5082894547- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- RNA Interference and Gene Delivery
- Surfactants and Colloidal Systems
- Microencapsulation and Drying Processes
- Lipid Membrane Structure and Behavior
- Occupational and environmental lung diseases
- Respiratory and Cough-Related Research
- Cystic Fibrosis Research Advances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Curcumin's Biomedical Applications
- Asthma and respiratory diseases
- Ocular Surface and Contact Lens
- Bee Products Chemical Analysis
- Proteins in Food Systems
- Polysaccharides Composition and Applications
- Analytical Methods in Pharmaceuticals
- Pneumonia and Respiratory Infections
- 3D Printing in Biomedical Research
- Pharmaceutical studies and practices
- Protein purification and stability
- Nanoplatforms for cancer theranostics
University of Parma
2016-2025
University of Technology Sydney
2012-2020
GTx (United States)
2017
Institute of Biomedical Technologies
2016
University of Milan
2016
Centre National de la Recherche Scientifique
2005
Université Paris-Saclay
2005
Université Paris Cité
2005
Institut de Chimie de la Matière Condensée de Bordeaux
2005
New folate-conjugated superparamagnetic maghemite nanoparticles have been synthesized for the intracellular hyperthermia treatment of solid tumors. These ultradispersed nanosystems characterized their physicochemical properties and tumor cell targeting ability, facilitated by surface modification with folic acid. Preliminary experiments heating under influence an alternating magnetic field at 108 kHz also performed. The nanoparticle size, charge, colloidal stability assessed in various...
Drug delivery to the brain represents a challenge, especially in therapy of central nervous system malignancies. Simvastatin (SVT), as with other statins, has shown potential anticancer properties that are difficult exploit (CNS). In present work physico–chemical, mucoadhesive, and permeability-enhancing simvastatin-loaded poly-ε-caprolactone nanocapsules coated chitosan for nose-to-brain administration were investigated. Lipid-core (LNCchit) different molecular weight (MW) prepared by novel...
Nanoparticles are promising mediators to enable nasal systemic and brain delivery of active compounds. However, the possibility reaching therapeutically relevant levels exogenous molecules in body is strongly reliant on ability nanoparticles overcome biological barriers. In this work, three paradigmatic nanoformulations vehiculating poorly soluble model drug simvastatin were addressed: (i) hybrid lecithin/chitosan (LCNs), (ii) polymeric poly-ε-caprolactone nanocapsules stabilized with...
Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases. However, such are extremely elusive via the conventional oral administration. The purpose present study was prepare and characterize physicochemical properties in vivo biodistribution simvastatin-loaded lecithin/chitosan nanoparticles (SVT-LCNs) suitable for nasal administration view an improved delivery brain.Chitosan, lecithin, different...
Nasal administration has been proposed as a potential approach for the delivery of drugs to central nervous system. Ribavirin (RBV), an antiviral drug potentially useful treat viral infections both in humans and animals, previously demonstrated attain several brain compartments after nasal administration. Here, powder formulation form agglomerates comprising micronized RBV spray-dried microparticles containing excipients with absorption enhancing properties, i.e. mannitol, chitosan,...
Burns are serious traumas related to skin damage, causing extreme pain and possibly death. Natural drugs such as Aloe vera vitamin E have been demonstrated be beneficial in formulations for wound healing. The aim of this work is develop evaluate polymeric films containing treat wounds caused by burns. Polymeric different quantities sodium alginate polyvinyl alcohol (PVA) were characterized their mechanical properties drug release. films, which produced, thin, flexible, resistant, suitable...