A5031878942- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Drug Solubulity and Delivery Systems
- Microbial Metabolites in Food Biotechnology
- Nanoparticles: synthesis and applications
- Lung Cancer Research Studies
- Inhalation and Respiratory Drug Delivery
- Diet and metabolism studies
- Advancements in Transdermal Drug Delivery
- Antimicrobial agents and applications
- Polymer Nanocomposite Synthesis and Irradiation
- MicroRNA in disease regulation
- Fullerene Chemistry and Applications
- Crystallization and Solubility Studies
- Peptidase Inhibition and Analysis
- Skin Protection and Aging
- Sirtuins and Resveratrol in Medicine
- Carbon Nanotubes in Composites
- Food composition and properties
- Analytical Methods in Pharmaceuticals
Universidade Federal do Rio Grande do Sul
2012-2020
Instituto de Ciências Farmacêuticas
2014
Universidade Federal de Santa Maria
2007-2012
Drug delivery to the brain represents a challenge, especially in therapy of central nervous system malignancies. Simvastatin (SVT), as with other statins, has shown potential anticancer properties that are difficult exploit (CNS). In present work physico–chemical, mucoadhesive, and permeability-enhancing simvastatin-loaded poly-ε-caprolactone nanocapsules coated chitosan for nose-to-brain administration were investigated. Lipid-core (LNCchit) different molecular weight (MW) prepared by novel...
It is desirable and challenging to prevent E-resveratrol (E-RSV) from photoisomerizing its Z-configuration preserve biological pharmacological activities. The aim of this research was evaluate the photostability E-RSV-loaded supramolecular structures skin penetration profile chemically physically stable nanoestructured formulations. Different were developed act as carriers for E-RSV, that is, liposomes, polymeric lipid-core nanocapsules nanospheres solid lipid nanoparticles. degrees these...
Drug delivery to the brain represents a challenge especially in therapy of central nervous system malignancies. Simvastatin (SVT), as other statins, has shown potential anticancer properties that are difficult exploit CNS. In present work physico-chemical, mucoadhesive and permeability enhancing simvastatin-loaded poly-ε-caprolactone nanocapsules coated with chitosan for nose-to-brain administration were investigated. Lipid-core different molecular weight (MW) chitosans (LNCchit)...
Aim: To characterize a method to isolate glioma-derived extracellular vesicles (GEVs) and understand their role in immune system modulation glioma progression. Materials & methods: GEVs were isolated by differential centrifugation from C6 cell supernatant characterized size expression of CD9, HSP70, CD39 CD73. The model was performed injecting cells into the right striatum Wistar rats following groups: controls (C6 alone), coinjection + GEVs) intranasal administration followed cells, tumor...
<b><i>Aim:</i></b> The purpose of this study was to characterise C<sub>60</sub>-poly(vinylpyrrolidone) (PVP) dispersions, analyse the cutaneous absorption fullerenes as well evaluate whether UVA radiation (UVA-R) could modify its permeation profile. <b><i>Methods:</i></b> Dispersions were characterised according their pH, particle size, zeta potential, and morphology. Skin studies performed using porcine or human skin under sham...
The effect of formulation parameters on the in vitro release profile a poorly soluble drug was investigated using rimonabant as model drug.A dissolution test developed to evaluate from both 20mg film-coated tablet and capsule dosage forms.The applied compare profiles different forms drug.Four commercially available products were evaluated, results obtained show very distinct rates extent among them.The type excipients used significantly influenced rate formulations studied.