A5037764707- Inhalation and Respiratory Drug Delivery
- Advanced Drug Delivery Systems
- Wound Healing and Treatments
- Polymer Surface Interaction Studies
- Silk-based biomaterials and applications
- Proteoglycans and glycosaminoglycans research
- Advanced biosensing and bioanalysis techniques
- Drug Solubulity and Delivery Systems
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Analytical Chemistry and Chromatography
- Advancements in Transdermal Drug Delivery
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Sperm and Testicular Function
- Protein purification and stability
- Lipid Membrane Structure and Behavior
- Osteoarthritis Treatment and Mechanisms
- Surfactants and Colloidal Systems
- 3D Printing in Biomedical Research
- Microbial infections and disease research
- Collagen: Extraction and Characterization
- Cell Adhesion Molecules Research
- Herpesvirus Infections and Treatments
University of Parma
2016-2025
Drug delivery to the brain represents a challenge, especially in therapy of central nervous system malignancies. Simvastatin (SVT), as with other statins, has shown potential anticancer properties that are difficult exploit (CNS). In present work physico–chemical, mucoadhesive, and permeability-enhancing simvastatin-loaded poly-ε-caprolactone nanocapsules coated chitosan for nose-to-brain administration were investigated. Lipid-core (LNCchit) different molecular weight (MW) prepared by novel...
The augmented demand for medical devices devoted to tissue regeneration and possessing a controlled micro-architecture means there is need industrial scale-up in the production of hydrogels. A new 3D printing technique was applied automation freeze-gelation method preparation chitosan scaffolds with porosity. For this aim, dedicated printer built in-house: preliminary effort has been necessary explore parameter space optimize results terms geometry, tolerances mechanical properties product....
The growing demand for personalized medicine requires innovation in drug manufacturing to combine versatility with automation. Here, three-dimensional (3D) printing was explored the production of chitosan (CH)/alginate (ALG)-based hydrogels intended as active dressings wound healing. ALG were loaded 0.75% w/v silver sulfadiazine (SSD), selected a model commonly used therapeutic treatment infected burn wounds, and four different 3D CH/ALG architectures designed modulate release this compound....
Abstract 3D biomaterial manufacturing strategies show an extraordinary driving force for the development of innovative therapies in tissue engineering field. Here, behaviour printed chitosan (CH)-based scaffolds was explored as a function post-printing gelation process. To this purpose, gel forming properties different media were tested on their capability to retain structure, water content, mechanical resistance and surface/internal porosity. Three (i.e. KOH 1.5 M, Na 2 CO 3 ammonia...
TPGS (D-α-tocopheryl polyethylene glycol 1000 succinate) polymeric micelles show interesting properties for ocular administration thanks to their solubilization capability, nanometric size and tissue penetration ability. However, formulations are generally characterized by low viscosity, poor adhesion very short retention time at the site. Therefore, idea behind this work is preparation characterization of a crosslinked film based on xanthan gum that contains capable controlling release. The...
The nasal cavity has become a focal point for drug delivery research. Beyond its use in treating local diseases, the route is appealing due ability to deliver systemically potent drugs with low oral bioavailability. Recent interest vaccination driven significant pre-clinical and clinical advancements. Further R&D holds promise expanding medications, offering innovative healthcare solutions. This review explores strategies using polysaccharides enhance of hydrophilic drugs, peptides,...
This paper provides an analytical characterization of chitosan scaffolds obtained by freeze-gelation toward the uptake and controlled release chondroitin sulphate (CS), as cartilage repair agent, under different pH conditions. Scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), liquid chromatography-UV spectrophotometry (LC-UV) techniques were exploited to obtain qualitative quantitative descriptions polymer drug behaviour in...
Drug delivery to the brain represents a challenge especially in therapy of central nervous system malignancies. Simvastatin (SVT), as other statins, has shown potential anticancer properties that are difficult exploit CNS. In present work physico-chemical, mucoadhesive and permeability enhancing simvastatin-loaded poly-ε-caprolactone nanocapsules coated with chitosan for nose-to-brain administration were investigated. Lipid-core different molecular weight (MW) chitosans (LNCchit)...
Imiquimod (IMQ) has been successfully formulated to date mainly as semi-solid lipophilic formulations for topical application. In this study, we investigated the solubility of IMQ in solvents suitable developing innovative form powder obtained, instance, by spray drying; thus, water, ethanol, methanol, acetone, acetonitrile, and dimethyl sulfoxide were tested at different temperatures. Temperature variations, stirring intensity, contact time between solvent greatly affected evaluation...
Dry powder inhalers (DPIs) have gained increasing clinical acceptance in the local treatment of lung diseases due to their ability meet evolving needs patients while avoiding environmental concerns. However, some formulations for DPIs still encounter performance limitations terms aerodynamic properties and achievement therapeutic doses. Innovative aerogel processed using combined supercritical CO2 (scCO2)-based technologies can overcome these limitations, especially case poorly water-soluble...
Nasal vaccination has been shown to provide optimal protection against respiratory pathogens. However, mucosal requires the implementation of specific immunization strategies improve its effectiveness. Nanotechnology appears a key approach effectiveness vaccines, since several nanomaterials mucoadhesion, enhance permeability, control antigen release and possess adjuvant properties. Mycoplasma hyopneumoniae is main causative agent enzootic pneumonia in pigs, disease responsible for...
The aim of the project was to develop and characterise powders containing a probiotic (Lactiplantibacillus plantarum [Lpb. plantarum], Lacticaseibacillus rhamnosus, or Lactobacillus acidophilus) be administered lung for containment pathogen growth in patients with infections.
The aim of the present study was to investigate whether chitosan-based scaffolds modified with D-(+) raffinose and enriched thiol-modified gelatin could selectively improve osteoblast adhesion proliferation.
The search for best performing carriers dry powder inhalers is getting a great deal of interest to overcome the limitations posed by lactose. aerosolization adhesive mixtures between carrier and micronized drug strongly influenced solid-state properties. This work aimed at crystallizing kinetically stable D-mannitol polymorphs investigating their performance when used in with two model drugs (salbutamol sulphate, SS, budesonide, BUD) using median median/high resistance inhaler. A further...
Active dressings acting on multiple fronts are requested in the field of care for chronic skin ulcers order to ameliorate patient compliance and tissue restoration. Currently, three-dimensional polymeric hydrogels widely investigated; however, no prototypes aiming control oxidative stress bacterial proliferation wound bed have been developed up until now. The present work describes formulation a novel chitosan-based printable material containing α-tocopherol at stable dosages obtain...
A decisive step in cell-biomaterial interaction is represented by the adsorption of proteins at interface, whose fine control may be useful to trigger proper cell response. To this purpose, we can selectively protein on biomaterials means aptamers. Aptamers selected recognize fibronectin dramatically enhance chitosan ability promote proliferation and adhesion, but underlying biological mechanism remains unknown. We supposed that aptamers contributed ameliorate an advantageous geometrical...