A5049465474- 3D Printing in Biomedical Research
- Wound Healing and Treatments
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticles: synthesis and applications
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Additive Manufacturing and 3D Printing Technologies
- Alzheimer's disease research and treatments
- Graphene and Nanomaterials Applications
- Tissue Engineering and Regenerative Medicine
- Nanoparticle-Based Drug Delivery
- Lipoproteins and Cardiovascular Health
- Bone Tissue Engineering Materials
- Pressure Ulcer Prevention and Management
- Metabolism, Diabetes, and Cancer
- Advanced Sensor and Energy Harvesting Materials
- Skin Protection and Aging
- Skin and Cellular Biology Research
- Dental Implant Techniques and Outcomes
- Tryptophan and brain disorders
- Lipid Membrane Structure and Behavior
- Cholesterol and Lipid Metabolism
- Computational Drug Discovery Methods
- Fibroblast Growth Factor Research
University of Parma
2020-2023
Recent advances in 3D printing technologies and materials have enabled rapid development of innovative sensors for applications different aspects human life. Various been adopted to fabricate biosensors or some their components thanks the advantages these methodologies over traditional ones, such as end-user customization prototyping. In this review, works published last two years on 3D-printed are considered grouped basis applied fields application, highlighting main analytical parameters....
The growing demand for personalized medicine requires innovation in drug manufacturing to combine versatility with automation. Here, three-dimensional (3D) printing was explored the production of chitosan (CH)/alginate (ALG)-based hydrogels intended as active dressings wound healing. ALG were loaded 0.75% w/v silver sulfadiazine (SSD), selected a model commonly used therapeutic treatment infected burn wounds, and four different 3D CH/ALG architectures designed modulate release this compound....
Here, a formulation of silver nanoparticles (AgNPs) and two natural polymers such as alginate (ALG) nanocrystalline cellulose (CNC) was developed for the 3D printing scaffolds with large surface area, improved mechanical resistance sustained capabilities to promote antimicrobial cytotoxic effects. Mechanical resistance, water content, morphological characterization distribution were provided. As applications, comparable potency against S. aureus P. aeruginosa demonstrated by in vitro tests...
Increasing evidence highlights the importance of novel players in Alzheimer's disease (AD) pathophysiology, including alterations lipid metabolism and neuroinflammation. Indeed, a potential involvement Proprotein convertase subtilisin/kexin type 9 (PCSK9) AD has been recently postulated. Here, we first investigated effects PCSK9 on neuroinflammation vitro. Then, examined impact genetic ablation cognitive performance severe mouse model AD. Finally, same animals evaluated effect loss Aβ...
Derivatives [i.e. proteins and exopolysaccharides (EPS)] from Lactobacillus delbrueckii subsp. bulgaricus (LB) were extracted, characterized, for the first time used in production of novel self-crosslinking 3D printed alginate/hyaluronic acid (ALG/HA) hydrogels, as high-value functional biomaterials with therapeutic potentials regenerative medicine applications. coming two different LB strains, LB1865 LB1932, tested in-vitro compared their cytotoxicity effect on proliferation migration human...
3D-printed hydrogels are particularly advantageous as drug-delivery platforms but their loading with water-soluble active compounds remains a challenge requiring the development of innovative inks. Here, we propose new 3D extrusion-based approach that, by exploiting internal gelation alginate, avoids post-printing crosslinking process and allows epirubicin-HCl (EPI). The critical combinations calcium carbonate d-glucono-δ-lactone (GDL) combined scaffold production parameters (extrusion time,...
Two antimicrobial agents such as silver nanoparticles (AgNPs) and titanium dioxide (TiO2) have been formulated with natural polysaccharides (chitosan or alginate) to develop innovative inks for the rapid, customizable, extremely accurate manufacturing of 3D-printed scaffolds useful dressings in treatment infected skin wounds. Suitable chemical-physical properties applicability these devices were demonstrated through evaluation water content (88-93%), mechanical strength (Young's modulus...
Active dressings acting on multiple fronts are requested in the field of care for chronic skin ulcers order to ameliorate patient compliance and tissue restoration. Currently, three-dimensional polymeric hydrogels widely investigated; however, no prototypes aiming control oxidative stress bacterial proliferation wound bed have been developed up until now. The present work describes formulation a novel chitosan-based printable material containing α-tocopherol at stable dosages obtain...
Abstract We engineered an in vitro model of bioartificial 3D bone organoid consistent with anatomical and vascular microenvironment common to mammalian flat short bones. To achieve this, we chose the decellularized–decalcified matrix adult male rat scapula, implemented reconstruction its intrinsic vessels, obtained through original intravascular perfusion polylevolactic (PLLA), followed by coating PLLA‐fabricated vascularization tail collagen. As a result, geometry native cortical cancellous...
Collagens, elastin, fibrillin, decorin, and laminin are key constituents of the extracellular matrix basement membrane mammalian organs. Thus, changes in their quantities may influence mechanochemical regulation resident cells. Since maintenance a native stromal composition is requirement for three-dimensional (3D) matrix-based recellularization techniques tissue engineering, we studied decellularization detergents on these proteins porcine kidney, liver, pancreas, skin. Using quick...
Disordered and hypomineralized woven bone formation by dysfunctional mesenchymal stromal cells (MSCs) characterize delayed fracture healing endocrine -metabolic disorders like fibrous dysplasia Paget disease of bone. To shed light on molecular players in osteoblast differentiation, formation, mineralization MSCs we looked at the intermediate filament desmin (DES) during skeletogenic commitment rat marrow (rBMSCs), where its bone-related action remains elusive.
Two antimicrobial agents such as silver nanoparticles (AgNPs) and titanium dioxide (TiO2) have been formulated with natural polysaccharides (chitosan or alginate) to develop innovative inks for the rapid, customizable, extremely accurate manufacturing of 3D printed scaffolds useful dressings in treatment infected skin wounds. Suitable chemical-physical properties applicability these devices were demonstrated through evaluation water content (88-93%), mechanical strength (Young’s modulus...
A simple and reliable targeted liquid chromatography-electrospray-tandem mass spectrometry (LC-MS/MS) method was developed validated through the selection of two biomarker peptides for identification determination bovine insulin like growth factor-1 (IGF-1) in milk samples. Two urea-based sample extraction procedures were tested. The validation results provided detection limits at 1-5 ng IGF-1/mL level as a function matrix, precision ranged from 3 to 8% accuracy different matrices assured....