A5073188827- Bone Tissue Engineering Materials
- Calcium Carbonate Crystallization and Inhibition
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Physics of Superconductivity and Magnetism
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Dental materials and restorations
- Collagen: Extraction and Characterization
- biodegradable polymer synthesis and properties
- Tissue Engineering and Regenerative Medicine
- Superconductivity in MgB2 and Alloys
- Additive Manufacturing and 3D Printing Technologies
- Superconducting Materials and Applications
- Nanoparticle-Based Drug Delivery
- Bone and Dental Protein Studies
- Periodontal Regeneration and Treatments
- Bone health and osteoporosis research
- Osteoarthritis Treatment and Mechanisms
- Advanced ceramic materials synthesis
- Facial Trauma and Fracture Management
- Titanium Alloys Microstructure and Properties
- Advanced materials and composites
- Bone health and treatments
Institute of Science and Technology for Ceramics
2016-2025
National Research Council
2016-2025
Institute of Nanostructured Materials
2021
Ospedale per gli Infermi
2014-2019
National Academies of Sciences, Engineering, and Medicine
2003-2019
Finceramica (Italy)
2019
Houston Methodist
2009-2018
Istituto Ortopedico Rizzoli
2013-2018
Smith College
2018
Syracuse University
2018
Replacement of bone tissue by graft materials and products engineering having composition, structure, biological features that mimic natural is a goal to be pursued. A biomimetic synthesis was performed prepare new bone-like composites constituted hydroxyapatite nanocrystals self-assembled type I collagen fibers. We used inspired approach proved the systems stored processed information at molecular level. Two different methodologies were used: dispersion synthetic in telopeptides free...
In biomedicine, magnetic nanoparticles provide some attractive possibilities because they possess peculiar physical properties that permit their use in a wide range of applications. The concept guidance basically spans from drug delivery and hyperthermia treatment tumours, to tissue engineering, such as magneto-mechanical stimulation/activation cell constructs mechanosensitive ion channels, cell-seeding procedures, controlled proliferation differentiation. Accordingly, the aim this study was...
Inhalation delivers drug-loaded nanoparticles to the heart, improving cardiac function in murine and porcine models.
Augmentation of regenerative osteogenesis represents a premier clinical need, as hundreds thousands patients are left with insufficient healing bony defects related to host insults ranging from congenital abnormalities traumatic injury surgically-induced deficits. A synthetic material that closely mimics the composition and structure human osteogenic niche great potential successfully address this high demand. In study, magnesium-doped hydroxyapatite/type I collagen scaffold was fabricated...
Hydroxyapatite (HA) bone scaffolds characterized by highly organized hierarchical structures have been obtained chemically transforming native woods through a sequence of thermal and hydrothermal processes. The whole chemical conversion has carried out five steps from wood to porous hydroxyapatite: 1) pyrolysis ligneous raw materials produce carbon templates the natural complex anisotropic pore structure; 2) carburization process vapour or liquid calcium permeation yield carbide; 3)...
Superparamagnetic nanoparticles (MNPs) have been progressively explored for their potential in biomedical applications and particular as a contrast agent diagnostic imaging, magnetic drug delivery more recently tissue engineering applications. Considering the importance of having safe MNPs such applications, essential role iron bone remodelling, this study developed analysed novel biocompatible bioreabsorbable superparamagnetic nanoparticles, that avoid use poorly tolerated magnetite based...
A bioinspired mineralization process was applied to develop biomimetic hybrid scaffolds made of (Fe2+/Fe3+)-doped hydroxyapatite nanocrystals nucleated on self-assembling collagen fibers and endowed with super-paramagnetic properties, minimizing the formation potentially cytotoxic magnetic phases such as magnetite or other iron oxide phases. Magnetic composites were prepared at different temperatures, effect this parameter reaction yield in terms degree, morphology, degradation,...
In the past few years, researchers have focused on design and development of three-dimensional (3D) advanced scaffolds, which offer significant advantages in terms cell performance. The introduction magnetic features into scaffold technology could innovative opportunities to control populations within 3D microenvironments, with potential enhance their use tissue regeneration or cell-based analysis. present study, fully biodegradable nanocomposite scaffolds for bone engineering, consisting a...
The incorporation of foreign ions, such as Mg2+, exhibiting a biological activity for bone regeneration is presently considered promising route increasing the bioactivity bone-engineering scaffolds. In this work, morphology, structure, and surface hydration biomimetic nanocrystalline apatites were investigated before after exchange with Mg2+ by combining chemical alterations (ion exchange, H2O−D2O exchanges) physical examinations (Fourier transform infrared spectroscopy (FTIR)...
In case of degenerative disease or lesion, bone tissue replacement and regeneration is an important clinical goal. particular, nowadays, critical size defects rely on the engineering scaffolds that are 3D structural supports, allowing cellular infiltration subsequent integration with native tissue. Several ceramic hydroxyapatite (HA) high porosity good osteointegration have been developed in past few decades but they not solved completely problems related to defects. present study we a novel...
Abstract Demineralization of dental hard tissue is a widespread problem and the main responsible for caries dentin hypersensitivity. The most promising strategies to induce precipitation new mineral phase are application materials releasing gradually Ca 2+ PO 4 3− ions or mimicking host tissue. However, design formulations covering both processes so far challenge in preventive dentistry. In this work, we have synthesized innovative biomimetic amorphous calcium phosphate (ACP), which has...