A5062473863- Bone Tissue Engineering Materials
- Additive Manufacturing and 3D Printing Technologies
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- 3D Printing in Biomedical Research
- Dental materials and restorations
- Orthopaedic implants and arthroplasty
- Spine and Intervertebral Disc Pathology
- Dental Implant Techniques and Outcomes
- Musculoskeletal pain and rehabilitation
- Graphene and Nanomaterials Applications
- Additive Manufacturing Materials and Processes
- Tissue Engineering and Regenerative Medicine
- Endodontics and Root Canal Treatments
- Silk-based biomaterials and applications
- Photopolymerization techniques and applications
- Hydrogels: synthesis, properties, applications
- Manufacturing Process and Optimization
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Knee injuries and reconstruction techniques
- Breast Implant and Reconstruction
- Augmented Reality Applications
- Cellular and Composite Structures
- Supramolecular Self-Assembly in Materials
University of Naples Federico II
2006-2025
National Research Council
2014-2023
Institute of Polymers, Composites and Biomaterials
2014-2023
University of Chinese Academy of Sciences
2023
Case Western Reserve University
2019
Cornell University
2019
Sahlgrenska University Hospital
2019
National Academies of Sciences, Engineering, and Medicine
2010-2017
University of Campania "Luigi Vanvitelli"
2016
Institute of Molecular and Cell Biology
2011
In recent years, a great effort has been devoted to developing new generation of materials for aeronautic applications. The driving force behind this is the reduction costs, by extending service life aircraft parts (structural and engine components) increasing fuel efficiency, load capacity flight range. present paper examines most important classes metallic including Al alloys, Ti Mg steels, Ni superalloys metal matrix composites (MMC), with scope provide an overview advancements highlight...
In biomedicine, magnetic nanoparticles provide some attractive possibilities because they possess peculiar physical properties that permit their use in a wide range of applications. The concept guidance basically spans from drug delivery and hyperthermia treatment tumours, to tissue engineering, such as magneto-mechanical stimulation/activation cell constructs mechanosensitive ion channels, cell-seeding procedures, controlled proliferation differentiation. Accordingly, the aim this study was...
This paper investigates the use of PCL and PCL/PLA scaffolds produced using a novel additive biomanufacturing system called BioCell Printing. blends were prepared melt blend solvent casting techniques. Scaffolds with 0/90° architecture 350 μm pore size morphologically evaluated scanning electron microscopy atomic force microscopy. Biological tests, osteosarcoma cell line G-63, performed Alamar Blue Assay Alkaline Phosphatase Activity. Results show that Printing produces regular reproducible...
Purpose This paper aims to report a detailed study regarding the influence of process parameters on morphological/mechanical properties poly(ε‐caprolactone) (PCL) scaffolds manufactured by using novel extrusion‐based system that is called BioExtruder. Design/methodology/approach In this authors focused investigations four parameters, namely liquefier temperature (LT), screw rotation velocity (SRV), deposition (DV) and slice thickness (ST). Scaffolds were fabricated employing three different...
In the past few years, researchers have focused on design and development of three-dimensional (3D) advanced scaffolds, which offer significant advantages in terms cell performance. The introduction magnetic features into scaffold technology could innovative opportunities to control populations within 3D microenvironments, with potential enhance their use tissue regeneration or cell-based analysis. present study, fully biodegradable nanocomposite scaffolds for bone engineering, consisting a...
Novel additive manufacturing processes are increasingly recognized as ideal techniques to produce 3D biodegradable structures with optimal pore size and spatial distribution, providing an adequate mechanical support for tissue regeneration while shaping in-growing tissues. With regard the biological performances of scaffolds, geometry play a crucial role. In this study, novel integrated automated system production in vitro culture constructs, known BioCell Printing, was used only manufacture...
The current research was focused on a further insight into the mechanical properties of 3D parts printed with virgin and recycled polylactic acid (PLA). A first set specimens PLA filament mechanically tested. Such were then ground up re-extruded using homemade extruder. employed to manufacture new which also analysed. Three recycling processes performed assess effect properties. obtained results suggested that printing may be viable option.
Purpose – The main purpose of this research work is to study the effect poly lactic acid (PLA) addition into (e-caprolactone) (PCL) matrices, as well influence mixing process on morphological, thermal, chemical, mechanical and biological performance 3D constructs produced with a novel biomanufacturing device (BioCell Printing). Design/methodology/approach Two processes are used prepare PCL/PLA blends, namely melt blending solvent casting. PCL scaffolds via BioCell Printing using 300-μm...
Chitosan (Ch) is a nontoxic and biocompatible polysaccharide extensively used in biomedical applications. Ch, as polycation, can be combined with anionic polymers by layer-by-layer (LbL) self-assembly, giving rise to multilayered complexed architectures. These structures tissue engineering strategies, drug delivery systems, or artificial matrices mimicking the extracellular microenvironment. In this work, Ch was poly(γ-glutamic acid) (γ-PGA). γ-PGA polyanion, which microbially produced,...
A three dimensional magnetic patterning of two cell types was realised in vitro inside an additive manufactured scaffold, as a conceptual precursor for the vascularised tissue. The realisation separate arrangements vascular and osteoprogenitor cells, labelled with biocompatible nanoparticles, established on opposite sides scaffold fibres under effect non-homogeneous gradients loading configuration. magnetisation amplified guiding effects by additional trapping cells due to short range...
Bone tissue engineering is strongly dependent on the use of three-dimensional scaffolds that can act as templates to accommodate cells and support ingrowth. Despite its wide application in research, polycaprolactone presents a very limited ability induce adhesion, proliferation osteogenic cell differentiation. To overcome some these limitations, different calcium phosphates, such hydroxyapatite tricalcium phosphate, have been employed with relative success. This work investigates influence...
Over the past few years, influence of static or dynamic magnetic fields on biological systems has become a topic considerable interest. Magnetism recently been implicated to play significant roles in regulation cell responses and, for this reason, it is revolutionizing many aspects healthcare, also suggesting new opportunities tissue engineering. The aim present study was analyze effect application mode time-dependent field behavior human mesenchymal stem cells (hMSCs) seeded 3D...
In total knee arthroplasty (TKA) and hip replacement (THR) the restoration of normal joint function represents a fundamental feature. A prosthetic must be able to provide motions transmit functional loads. As reported in literature, stress distribution may altered bones after implantation prosthesis. Some scientific works have also correlated uncemented TKA progressive decrease bone density below tibial component. Antibiotic-loaded cements are commonly employed conjunction with systemic...
Tissue engineered scaffolds must have an organized and repeatable microstructure which enables cells to assemble in ordered matrix that allows adequate nutriental perfusion. In this work, evaluate the reciprocal cell interactions of endothelial osteoblast-like cells, human (MG63) Human Umbilical Vein Endothelial Cells (HUVEC) were co-seeded onto 3D geometrically controlled porous poly(ε-caprolactone) (PCL) cultured by means a rotary culture system (RCCS-4DQ). our dynamic co-culture system,...
Abstract Magnetic scaffolds for bone tissue engineering based on a poly(ε‐caprolactone) (PCL) matrix and iron oxide (Fe 3 O 4 ) magnetic nanoparticles were designed developed through three‐dimensional (3D) fiber‐deposition technique. PCL/Fe characterized by 90/10 w/w composition. Tensile measurements carried out, nondestructive 3D imaging was performed microcomputed tomography (Micro‐CT). Furthermore, confocal analysis undertaken to investigate human mesenchymal stem cell adhesion spreading...
Synthetic scaffolds for tissue engineering coupled to stem cells represent a promising approach aiming promote the regeneration of large defects damaged tissues or organs. Magnetic nanocomposites formed by biodegradable poly(caprolactone) (PCL) matrix and superparamagnetic iron doped hydroxyapatite (FeHA) nanoparticles at different PCL/FeHA compositions have been successfully prototyped, layer on layer, through 3D bioplotting. measurements, mechanical testing, imaging were carried out...
The requirement of a multifunctional scaffold for tissue engineering capable to offer at the same time tunable structural properties and bioactive interface is still unpaired. Here we present three-dimensional (3D) biodegradable polymeric (PCL) scaffolds with controlled morphology, macro-, micro-, nano-mechanical performances endowed moieties (RGD peptides) surface. Such result was obtained by combination rapid prototyping (e.g., 3D fiber deposition) surface treatment approach (aminolysis...
The inability of the avascular region meniscus to regenerate has led use tissue engineering treat meniscal injuries. aim this study was evaluate ability fibrochondrocytes preseeded on PLDLA/PCL-T [poly(L-co-D,L-lactic acid)/poly(caprolactone-triol)] scaffolds stimulate regeneration whole meniscus. Porous (90/10) were obtained by solvent casting and particulate leaching. Compressive modulus 9.5±1.0 MPa maximum stress 4.7±0.9 evaluated. Fibrochondrocytes from rabbit menisci isolated, seeded...
Tissue engineered hydrogels hold great potential as nucleus pulposus substitutes (NP), they promote intervertebral disc (IVD) regeneration and re‐establish its original function. But, the key to their success in future clinical applications greatly depends on ability replicate native 3D micro‐environment circumvent limitation terms of mechanical performance. In present study, we investigated rheological/mechanical properties both ionic‐ (iGG‐MA) photo‐crosslinked methacrylated gellan gum...