A5071227620- Pregnancy and preeclampsia studies
- Advanced Glycation End Products research
- Mesenchymal stem cell research
- Sperm and Testicular Function
- Paraoxonase enzyme and polymorphisms
- Nitric Oxide and Endothelin Effects
- Reproductive Biology and Fertility
- Birth, Development, and Health
- Bone Tissue Engineering Materials
- Chemotherapy-induced cardiotoxicity and mitigation
- Tissue Engineering and Regenerative Medicine
- Lipid Membrane Structure and Behavior
- Pancreatic function and diabetes
- Salivary Gland Disorders and Functions
- Dental Implant Techniques and Outcomes
- Chemotherapy-induced organ toxicity mitigation
- PARP inhibition in cancer therapy
- Ovarian function and disorders
- Polyomavirus and related diseases
- Ion Transport and Channel Regulation
- Alzheimer's disease research and treatments
- Bone and Dental Protein Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Eating Disorders and Behaviors
- Telomeres, Telomerase, and Senescence
Marche Polytechnic University
2015-2025
Ospedali Riuniti di Ancona
1994-2003
Ospedali Riuniti Umberto I
2002
Istituto Nazionale di Riposo e Cura per Anziani
1997-1999
University of Milan
1997
Research Institute of Human Morphology
1995-1996
University of Bologna
1995
Istituto di Ematologia di Bologna
1995
Istituti di Ricovero e Cura a Carattere Scientifico
1994
Tissue engineered scaffolds must have an organized and repeatable microstructure which enables cells to assemble in ordered matrix that allows adequate nutriental perfusion. In this work, evaluate the reciprocal cell interactions of endothelial osteoblast-like cells, human (MG63) Human Umbilical Vein Endothelial Cells (HUVEC) were co-seeded onto 3D geometrically controlled porous poly(ε-caprolactone) (PCL) cultured by means a rotary culture system (RCCS-4DQ). our dynamic co-culture system,...
The expression of inducible nitric oxide synthase (iNOS) and vascular endothelial growth factor (VEGF) the level total oxyradical scavenging capacity have been evaluated extensively in cutaneous cells patients with psoriasis. As yet, no indications are available about undifferentiated cells, mesenchymal stem (MSCs), isolated from skin.To isolate MSCs psoriasis to compare them those obtained atopic healthy subjects, order analyse whether show some typical psoriatic profiles understand...
Purpose – The purpose of this study is to show how selective laser sintering (SLS) manufacturing bioresorbable scaffolds used for applications in bone tissue engineering. Design/methodology/approach Polycaprolactone (PCL) were computationally designed and then fabricated via SLS cartilage repair. Findings Preliminary biocompatibility data acquired using human mesenchymal stem cells (hMSCs) assuring a satisfactory scaffold colonization by hMSCs. Originality/value A promising procedure...
Melanoma represents the most aggressive skin cancer, being responsible for majority of deaths related with these neoplasms. Despite chemotherapy a frontline approach management advanced stages disease, it displayed poor response rates and short-term efficacy due to melanoma cell resistance. Therefore, discovery molecules that can be used effective targeted therapy is crucial. In this study, we evaluated impact paraoxonase-2 (PON2) silencing on proliferation, viability, resistance treatment...
Melanoma accounts for less than 5% of all cutaneous neoplasms but is responsible the greater part skin cancer-related deaths. Therefore, identification molecules that could serve as therapeutic target urgent. This study focused on enzyme nicotinamide N-methyltransferase (NNMT). The effect NNMT knockdown cell proliferation and migration A375 melanoma cells was evaluated by MTT wound healing assays, respectively. Viability downregulating also explored under treatment with dacarbazine, a...
Oral squamous cell carcinoma represents the most aggressive and frequent form of head neck cancer. Due to drug resistance, 5-year survival rate patients with advanced disease is less than 50%. In order identify molecular targets for effective oral cancer treatment, we focused on paraoxonase-2 enzyme. Indeed, based data previously obtained from preliminary immunohistochemistry Western blot analyses performed tissue specimens, enzyme was found be upregulated in tumor compared normal mucosa....
Objective To assess human unstimulated whole saliva components during pregnancy, to determine the relation, if any, between pregnancy and oral health, particularly total protein concentration, α‐amylase activity, sialic acid content calcium phosphate concentrations were evaluated. Design Cross‐sectional study. Participants Forty‐five healthy primigravid women; 15 nonpregnant women acted as controls. Results 1. A higher at 10 21 weeks of gestation with respect controls pregnant 40 weeks; 2. a...
The interaction between low density lipoproteins (LDL) and platelets might play a central role in the development of atherosclerosis diabetes. aim present study was to investigate whether glycation LDL is associated with modifications their physico-chemical functional properties action glycated (glycLDL) on platelets. were isolated from 15 healthy subjects. content thiobarbituric acid-reactive substances generalized polarization fluorescent probe Laurdan determined vitro. Platelets incubated...
Cutaneous neoplasms include melanoma and non-melanoma skin cancers (NMSCs). Among NMSCs, basal cell carcinoma (BCC) represents the most common lesion. On contrary, although accounting for less than 5% of all cancers, is responsible cutaneous malignancy-related deaths. Paraoxonase-2 (PON2) an intracellular enzyme exerting a protective role against production reactive oxygen species within mitochondrial respiratory chain. Recently, growing attention has been focused on exploring PON2 in...
Paraoxonase-2 (PON2) is a ubiquitously expressed intracellular protein that localized in the perinuclear region, endoplasmic reticulum (ER), and mitochondria, also associated with plasma membrane. PON2 functions as an antioxidant enzyme by reducing levels of reactive oxygen species (ROS) mitochondria ER through different mechanisms, thus having anti-apoptotic effect preventing formation atherosclerotic lesions. While antiatherogenic role played this has been extensively explored within...
Nowadays, custom-made subperiosteal implants are emerging as a solution in all those cases where there is lack of healthy bone tissue to support endosseous implants. The development innovative techniques has allowed the production grids that precisely match patient’s anatomy. Elucidating impact laser-melted Ti6Al4V on both hard and soft tissues with which they come into contact is, therefore, mandatory. In this study, we analyzed effects five different surface treatments human...
Abstract The cancer stem cell theory states that a subset of tumor cells, termed cells (CSCs), has the ability to self‐renew and differentiate within tumors. According this theory, CSCs would be mainly responsible for initiation, progression, resistance therapy, recurrence, metastasis. In study, culture system was setup enrich from bladder (T24), lung (A549), colorectal (CaCo‐2), osteosarcoma (MG63) lines, through sphere formation. Magnetic‐activated sorting also used further increase CSC...
Abstract Background Osteosarcoma (OS) is a primary bone malignancy that mostly affects young people, characterized by high metastatic potential, and marked chemoresistance responsible for disease relapse in most patients. Therefore, it necessary to identify novel molecules setup targeted strategies improve the clinical outcome. The enzyme nicotinamide N‐methyltransferase (NNMT) catalyses N‐methylation of other analogs, playing crucial role biotransformation drugs xenobiotics. NNMT...
Abstract Merkel cell carcinoma (MCC) is an aggressive skin cancer, with a propensity for early metastasis. Therefore, diagnosis and the identification of novel targets become fundamental. The enzyme nicotinamide N -methyltransferase (NNMT) catalyzes reaction -methylation other analogous compounds. Although NNMT overexpression was reported in many malignancies, significance its dysregulation cancer phenotype partly clarified. Several works demonstrated that promotes proliferation, migration,...