A5101971095- Oral and Maxillofacial Pathology
- Oral Health Pathology and Treatment
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Head and Neck Surgical Oncology
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Tumors and Oncological Cases
- Bone health and treatments
- Salivary Gland Disorders and Functions
- Cell death mechanisms and regulation
- Dental Implant Techniques and Outcomes
- Oral microbiology and periodontitis research
- Oral and gingival health research
- Bone and Joint Diseases
- Biochemical and Molecular Research
- Autoimmune Bullous Skin Diseases
- Cancer Immunotherapy and Biomarkers
- Hedgehog Signaling Pathway Studies
- Cancer and Skin Lesions
- Peptidase Inhibition and Analysis
- PARP inhibition in cancer therapy
- Cancer Diagnosis and Treatment
- Bone Tissue Engineering Materials
Marche Polytechnic University
2016-2025
Istituto Nazionale di Riposo e Cura per Anziani
2014-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
GTx (United States)
2018
Pirelli (Italy)
2018
Ospedali Riuniti di Ancona
2013-2014
I.R.C.C.S. Oasi Maria SS
2013-2014
University of Foggia
2004-2012
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2011
ASL Roma
2011
A single flexible sigmoidoscopy at around the age of 60 years has been proposed as an effective strategy for colorectal cancer (CRC) screening.We conducted a randomized controlled trial to evaluate effect screening on CRC incidence and mortality. questionnaire assess eligibility interest in was mailed 236,568 men women, aged 55-64 years, who were randomly selected from six centers Italy. Of 56,532 respondents, interested eligible subjects assigned intervention group (invitation...
The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role great rising importance, not only on the Quality Life (QoL) patients, but also decision-making by majority dentists oral surgeons involved in MRONJ (primary secondary). present paper reports update conclusions from Consensus Conference—held at Symposium Italian Society Oral Pathology Medicine (SIPMO) (20 October 2018, Ancona, Italy)—after newest recommendations (2020) were published two...
Background/Aims: Head and neck squamous cell carcinoma (HNSCC) ranks sixth worldwide for tumor-related mortality. A subpopulation of tumor cells, termed cancer stem cells (CSCs), has the ability to support growth. Therefore, profiling CSC-enriched populations could be a reliable tool study biology. Methods: We performed phenotypic characterization 7 HNSCC lines evaluated presence CSCs. CSCs from Hep-2 line primary cultures were enriched through sphere formation sphere-forming have been...
Abstract Background In patients with squamous cell carcinoma of the oral tongue (OTSCC), current tumor node metastasis staging system fails to identify at‐risk associated early relapse and poor prognosis despite complete surgical resection. Given importance tumor‐infiltrating lymphocytes (TILs) in development cancers, here we investigated prognostic significance immune phenotype OTSCC. Methods Hematoxylin‐eosin stained sections OTSCCs from 211 were evaluated. Cancers classified as (a)...
Aims One of the objectives current research is to customise treatment cancer patients. The achievement this objective requires stratification patients based on most significant prognostic factors. aims study were evaluate value tumour–stroma ratio (TSR), defined as proportion tumour cells relative surrounding stroma, in with oral tongue squamous cell carcinoma (OTSCC), and develop a nomogram clinicopathological features. Methods results Clinicopathological data 211 treated at ‘Ospedali...
Survival rate for oral tongue squamous cell carcinoma (OTSCC) is still poor and, despite Tumor-Node-Metastasis staging system has been recently updated, patients included under the same stage show difference in prognosis. Perineural invasion (PNI) emerged to be an indicator of tumor aggressive behavior and unfortunate events. In this study, we investigate clinic prognostic value PNI a cohort OTSCC patients.About 200 with were retrospectively evaluated presence PNI. was furtherly descripted...
We investigated expression levels of Nicotinamide N-Methyltransferase (NNMT), an enzyme Involved In the biotransformation many drugs and xenobiotic compounds, in oral squamous cell carcinoma (OSCC). Measurements were performed by semiquantitative RT-PCR quantitative real-time PCR tumor matched adjacent healthy tissue. Interestingly, NNMT was upregulated most favorable OSCCs, while no marked alterations between normal mucosa detected unfavorable OSCCs. Western blot immunohistochemical...
Oral squamous cell carcinoma represents the most aggressive and frequent form of head neck cancer. Due to drug resistance, 5-year survival rate patients with advanced disease is less than 50%. In order identify molecular targets for effective oral cancer treatment, we focused on paraoxonase-2 enzyme. Indeed, based data previously obtained from preliminary immunohistochemistry Western blot analyses performed tissue specimens, enzyme was found be upregulated in tumor compared normal mucosa....
Coeliac disease is characterized by oral manifestations, such as dental enamel defects and recurrent aphthae. In this study we compared the prevalence of aphthous stomatitis (RAS) between patients diagnosed with coeliac healthy controls.A total 72 were studied together 162 normal subjects controls to individualize in disease.Dental found 14/70 (20%) 9/159 (5.6%) controls. particular, 13/53 (24.5%) mixed or permanent dentition 1/17 (5.8%) children deciduous had defects. Altogether, 9/145...
Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer. Despite progress in treatment OSCC, overall survival has not improved substantially last three decades. Therefore, identification reliable biomarkers becomes essential to develop effective anti-cancer therapy. In this study, we focused on enzyme Nicotinamide N-methyltransferase (NNMT), which plays a fundamental role biotransformation many xenobiotics. Although several tumors have been associated with abnormal NNMT...