A5056401353- Oral Health Pathology and Treatment
- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Head and Neck Cancer Studies
- Oral health in cancer treatment
- Oral and Maxillofacial Pathology
- Oral microbiology and periodontitis research
- Skin and Cellular Biology Research
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Oral and gingival health research
- Salivary Gland Tumors Diagnosis and Treatment
- Salivary Gland Disorders and Functions
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Olfactory and Sensory Function Studies
- Antifungal resistance and susceptibility
- Platelet Disorders and Treatments
- Telomeres, Telomerase, and Senescence
- Advancements in Transdermal Drug Delivery
- Hormonal Regulation and Hypertension
- Biochemical Analysis and Sensing Techniques
- Dental Radiography and Imaging
The University of Melbourne
2016-2025
University of Jordan
2023-2024
Faculty (United Kingdom)
2023
Royal Dental Hospital of Melbourne
2019-2023
University of Naples Federico II
2006-2022
University of Campania "Luigi Vanvitelli"
2006-2022
Cooperative Research Centre for Mental Health
2016-2019
Melbourne Health
2013-2018
Institute for Research on Innovation and Services for Development
2014-2017
University Of Bristol Dental Hospital
2007-2013
Previous studies have demonstrated that senescent cancer-associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), unlike non-senescent CAFs stable (GS-OSCC), promoted keratinocyte invasion in vitro a paracrine manner. The mechanism by which this occurs is unclear. work to characterise the senescent-associated secretory phenotype (SASP) has used antibody arrays, technology limited availability of suitable antibodies. To extend an unbiased...
Adverse events associated with vaccine administration can manifest in the oral cavity and orofacial region. Hence, aim of this study was to compare adverse effects two recently authorised COVID-19 vaccines, namely BNT162b2 mRNA-1273.Publicly available data on mRNA-1273 vaccines were accessed from relevant regulatory authorities United States, Canada, European Union Kingdom. Both patient/recipient information healthcare professional fact sheets for each these drugs manually searched find...
The bioavailability of circulating and/or endogenous hydrocortisone (cortisol) in epidermal cells is a key determinant inflammatory disease and chronic wounds. It not known, however, whether can regulate tissue cortisol they are capable producing glucocorticoids. In the present study, we show by microarray analysis that express mRNAs to all major enzymes involved metabolic chain from cholesterol cortisol, including cytocrome P450 chain, 11β-hydroxysteroid dehydrogenases (HSD11Bs),...
Keratinocyte senescence acts as a barrier to tumor progression but appears be lost in late pre-malignancy yield genetically unstable oral squamous cell carcinomas (GU-OSCC); subset of OSCC possessing wild-type p53 and are stable (GS-OSCC). In this study, fibroblasts from GU-OSCC were senescent relative GS-OSCC, epithelial dysplastic tissues or normal mucosa, demonstrated by increased senescence-associated β-galactosidase (SA β-Gal) activity overexpression p16 INK4A . Keratinocytes produced...
Abstract Oral cancer is a highly aggressive malignancy with poor prognosis. This study examined the behaviour of fibroblast strains from normal oral mucosa, dysplastic epithelial tissue, and genetically stable (minimal copy number alterations—CNA; minimal loss heterozygosity—LOH; wild‐type p53; p16 $^{{\rm INK4A}}$ ) unstable (extensive CNA LOH; inactivation p53 squamous cell carcinoma (OSCC). Fibroblasts OSCC relative to other subtypes grew more slowly stimulated invasion non‐tumourigenic...
Abstract Background In patients with squamous cell carcinoma of the oral tongue (OTSCC), current tumor node metastasis staging system fails to identify at‐risk associated early relapse and poor prognosis despite complete surgical resection. Given importance tumor‐infiltrating lymphocytes (TILs) in development cancers, here we investigated prognostic significance immune phenotype OTSCC. Methods Hematoxylin‐eosin stained sections OTSCCs from 211 were evaluated. Cancers classified as (a)...
Mutations of the tumour-suppressor gene TP53 are most frequent somatic genomic alterations in head and neck squamous cell carcinoma (HNSCC). However, it is not yet clear whether specific mutations bear distinct clinical pathophysiological significance different HNSCC subgroups.A systematic bioinformatics appraisal was performed on 415 cases available The Cancer Genome Atlas (TCGA). following features were analysed correlated with known clinicopathological variables: mutational profile TP53,...
Abstract Detection of subjects with oral potentially malignant disorders in a population is key to early detection cancer (OC) consequent reduction cancer-related morbidity and mortality. Our aim was investigate the prevalence associated risk factors for OPMD representative provinces Indonesia. This cross-sectional study undertaken five Indonesian provinces: West Java (WJ), Jakarta (JKT), Papua (WP), Kalimantan (WK) Banda Aceh (BA). Respondents answered previously validated questionnaire...