A5013068093- Viral-associated cancers and disorders
- Head and Neck Cancer Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Oral Health Pathology and Treatment
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Lymphoma Diagnosis and Treatment
- Hippo pathway signaling and YAP/TAZ
- Respiratory viral infections research
- Immunotherapy and Immune Responses
- Oral and Maxillofacial Pathology
- Cancer-related Molecular Pathways
- Virus-based gene therapy research
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- RNA Research and Splicing
- Cancer Diagnosis and Treatment
- Animal Genetics and Reproduction
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
University of Malaya
2016-2025
Cancer Research Malaysia
2016-2025
Subang Jaya Medical Centre
2007-2019
Walsall Healthcare NHS Trust
2017
In-Q-Tel
2016
Faculty (United Kingdom)
2014
Hospital Kuala Lumpur
2007
Tengku Ampuan Rahimah Hospital
2007
St George's, University of London
2006
World Heart Federation
1977
Cellular senescence, the irreversible proliferative arrest seen in somatic cells after a limited number of divisions, is considered crucial barrier to cancer, but direct evidence for this vivo was lacking until recently. The best-known form human cell senescence attributed telomere shortening and DNA-damage response through p53 p21. There also more rapid dependent on p16-retinoblastoma pathway. p16 (CDKN2A) known melanoma susceptibility gene. Here, we use retrovirally mediated gene transfer...
Oral cancer is a major global health issue accounting for 177,384 deaths in 2018 and it most prevalent low- middle-income countries. Enabling automation the identification of potentially malignant lesions oral cavity would lead to low-cost early diagnosis disease. Building large library well-annotated key. As part MeMoSA <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> (Mobile Mouth Screening Anywhere) project, images are currently...
Multiplexed biomarker protein detection holds unrealized promise for clinical cancer diagnostics due to lack of suitable measurement devices and rigorously validated panels. Here we report an ultrasensitive electrochemical microfluidic array optimized measure a four-protein panel proteins, validate the accurate oral diagnostics. Unprecedented ultralow into 5–50 fg·mL–1 range was achieved simultaneous proteins interleukin 6 (IL-6), IL-8, vascular endothelial growth factor (VEGF), VEGF-C in...
Abstract Dysregulation of the Hippo signaling pathway and consequent YAP1 activation is a frequent event in human malignancies, yet underlying molecular mechanisms are still poorly understood. A pancancer analysis core kinases their candidate regulating molecules revealed few alterations canonical pathway, but very genetic FAT family atypical cadherins. By focusing on head neck squamous cell carcinoma (HNSCC), which displays FAT1 (29.8%), we provide evidence that functional loss results...
Abstract Oral cancer is a highly aggressive malignancy with poor prognosis. This study examined the behaviour of fibroblast strains from normal oral mucosa, dysplastic epithelial tissue, and genetically stable (minimal copy number alterations—CNA; minimal loss heterozygosity—LOH; wild‐type p53; p16 $^{{\rm INK4A}}$ ) unstable (extensive CNA LOH; inactivation p53 squamous cell carcinoma (OSCC). Fibroblasts OSCC relative to other subtypes grew more slowly stimulated invasion non‐tumourigenic...
Introduction:This study examined the concordance in clinical diagnosis of high-risk lesions oral cavity and referral decisions between examination (COE) teledentistry.Materials Methods:Sixteen individuals with a range potentially malignant disorders (OPMD) normal mucosa were included. Five areas photographed by three dentists using mobile phone cameras 5 MP-13 MP resolutions. On same day, patients given COE two medicine specialists (OMS) 3 weeks later, they reviewed images taken phone, was...
Objectives: To document the burden of oral cancer in South East Asia (SEA) and to examine gaps acquiring accurate data within these countries. Methods: Epidemiological on from countries SEA were obtained reviewed public population-based databases. Descriptions incidence mortality based GLOBOCAN 2012, prediction number cases deaths due also taken same database. The availability accessibility registry documented. Results: Five eleven have national registries, but reporting periods varied 2002...
The drug discovery and development pipeline is a long arduous process that inevitably hampers rapid development. Therefore, strategies to improve the efficiency of are urgently needed enable effective drugs enter clinic. Precision medicine has demonstrated genetic features cancer cells can be used for predicting response, emerging evidence suggest gene-drug connections could predicted more accurately by exploring cumulative effects many genes simultaneously.We developed DeSigN, web-based...
Background: Up to 86% of oral cancer (OC) patients present at the late stage where survival is dismal. Limited access specialist diagnosis a significant factor for presentation. The increasing use smartphones presents an opportunity digital technology facilitate early detection OC. Aim: To evaluate feasibility using Mobile Mouth Screening Anywhere (MeMoSA®) Methods: A mobile phone app named MeMoSA was developed and integrating this documentation lesions, communication between dentists...
The survival rate for patients with head and neck cancer (HNC) diagnosed cervical lymph node (cLN) or distant metastasis is low. Genomic alterations in the HRAS oncogene are associated advanced tumor stage HNC. Elucidation of molecular mechanisms by which mutated (HRASmut) facilitates HNC could lead to improved treatment options patients. Here, we examined driven mutant vitro vivo using HRASmut human cell lines, patient-derived xenografts, a novel syngeneic model. Genetic pharmacological...
Regulatory T cells (Tregs), a subset of CD4+ plays pivotal role in regulating the immune system. An increase Treg numbers enables cancer progression by dampening system and allowing tumor to evade detection destruction. expression inhibitory cytokines including TGF-β IL-10 are mechanisms which Tregs exert their suppressive function. However, presence oral patients is still unclear. In this study, circulating 39 24 healthy donors was examined studying CD4+CD25hiCD127low cell population...
Background: Dentists are typically the first professionals who approached to treat ailments within oral cavity. Therefore they should be well-equipped in detecting suspicious lesions during routine clinical practice. This study determined levels of knowledge on early signs and risk factors associated with cancer identified which influenced dentist participation prevention detection cancer. Materials Methods: A survey dentists' their practices was conducted using a 26-item self-administered...
Emerging biological and translational insights from large sequencing efforts underscore the need for genetically-relevant cell lines to study relationships between genomic alterations of tumors, therapeutic dependencies. Here, we report a detailed characterization novel panel clinically annotated oral squamous carcinoma (OSCC) lines, derived patients with diverse ethnicity risk habits. Molecular analysis by RNAseq copy number (CNA) identified that harbour CNA have been previously reported in...
New therapeutic targets for oral squamous cell carcinoma (OSCC) are urgently needed. We conducted genome-wide CRISPR-Cas9 screens in 21 OSCC lines, primarily derived from Asians, to identify genetic vulnerabilities that can be explored as targets. known and novel fitness genes demonstrate many previously identified OSCC-related cancer non-essential could have limited value, while other warrant further investigation their potential validate a distinctive dependency on YAP1 WWTR1 of the Hippo...
Background and Aim: Less than 50% of oral cancer cases are diagnosed at early stages the disease this is in part due to poor awareness lack knowledge on signs symptoms cancer. This study sought measure baseline Malaysia aimed increase public using a mass media campaign. Methods: Baseline impact campaign was measured self-administered questionnaires sent via email individuals. The aired two national television channels reach monitored through an independent programme monitoring system....
Integration of Epstein Barr virus (EBV) DNA into the human genome is a critical event in nasopharyngeal carcinogenesis. Here, we comprehensively characterize large-scale virus-human integration events four EBV positive carcinoma (NPC) cell lines and tumors using Nanopore long-read sequencing technology. We identified distinct types, with Type I being particularly notable, characterized by continuous long reads covering nearly entire genome. Our findings reveal involvement multiple inducing...
We identified ADAR1 as one of the top essential genes for oral squamous cell carcinoma (OSCC) survival from our genome-wide CRISPR/Cas9 screen in OSCC lines. In this study, we confirm that ADAR1-knockout (KO) inhibits viability and colony forming ability, induces apoptosis. report IFN-β treatment sensitizes less-dependent lines to KO-induced lethality. Overexpression ADAR1-p150, but not ADAR1-p110, rescued lethality upon KO, confirming IFN-inducible p150 is responsible survival. Using a...