A5064287074- RNA regulation and disease
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Viral Infections and Immunology Research
- interferon and immune responses
- RNA and protein synthesis mechanisms
- Environmental DNA in Biodiversity Studies
- Identification and Quantification in Food
- Viral Infections and Outbreaks Research
- Virus-based gene therapy research
- Hydrogen's biological and therapeutic effects
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Vectors
- Rabies epidemiology and control
- Biochemical effects in animals
- Nanoparticle-Based Drug Delivery
- Molecular Biology Techniques and Applications
- Thermoregulation and physiological responses
- Cancer-related molecular mechanisms research
Universiti Sains Malaysia
2018-2025
Southern University of Science and Technology
2021
University of Cambridge
2013
Long double-stranded RNA may undergo hyper-editing by adenosine deaminases that act on (ADARs), where up to 50% of residues be converted inosine. However, although numerous RNAs hyper-editing, the role for inosine-containing hyper-edited in cells is poorly understood. Nevertheless, editing plays a critical mammalian cells, as highlighted analysis ADAR-null mutants. In particular, long form ADAR1 (ADAR1p150) essential viability. Moreover, number studies have implicated ADAR1p150 various...
We identified ADAR1 as one of the top essential genes for oral squamous cell carcinoma (OSCC) survival from our genome-wide CRISPR/Cas9 screen in OSCC lines. In this study, we confirm that ADAR1-knockout (KO) inhibits viability and colony forming ability, induces apoptosis. report IFN-β treatment sensitizes less-dependent lines to KO-induced lethality. Overexpression ADAR1-p150, but not ADAR1-p110, rescued lethality upon KO, confirming IFN-inducible p150 is responsible survival. Using a...
The aim of the present study is to analyze viability anti-EGFR anchored immunonanoparticle (INP) bearing Paclitaxel (PTX) specifically bind EGFR protein on TNBC cells. NP was prepared by nanoprecipitation and characterized particle size, charge, entrapment drug release it. integrity confirmed SDS-PAGE. Cytotoxicity NPs cellular uptake analyzed with MDA-MB-468 type cancer cells expression PCR, qualitatively quantitatively. in-vivo antitumor activity INP determined using athymic mice model...
There is emerging evidence that hydrogen-rich water (H2-water) has beneficial effects on the physiological responses to exercise. However, few studies investigate its ergogenic potential. This randomized controlled trial examined of H2-water ingestion and exercise performance during incremental treadmill running. In a double-blind crossover design, 14 endurance-trained male runners (age, 34 ± 4 years; body mass, 63.1 7.2 kg; height, 1.72 0.05 m) were randomly assigned ingest 2 doses 290-mL...
Abstract Treating oral squamous cell carcinoma (OSCC) remains challenging due to limited knowledge of the critical genes that could affect survival in OSCC. We have previously utilized genome-wide CRISPR-Cas9 knockout functional screens explore genetic vulnerabilities OSCC and identified Adenosine deaminase acting on RNA (ADAR1) as one top fitness genes. ADAR1 is an interferon-stimulated gene (ISG) catalyses adenosine-to-inosine (A-to-I) editing double-stranded (dsRNA), which suppresses...