A5034311771- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Cholinesterase and Neurodegenerative Diseases
- vaccines and immunoinformatics approaches
- Bacterial biofilms and quorum sensing
- Cancer, Lipids, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Gut microbiota and health
- Amino Acid Enzymes and Metabolism
- Nerve injury and regeneration
- Vibrio bacteria research studies
- Synthesis and biological activity
- Liver Disease Diagnosis and Treatment
- Mesenchymal stem cell research
- Piperaceae Chemical and Biological Studies
- Drug-Induced Hepatotoxicity and Protection
- Electrochemical Analysis and Applications
- Hydrogels: synthesis, properties, applications
- Hibiscus Plant Research Studies
- Nanoparticles: synthesis and applications
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Natural Antidiabetic Agents Studies
Queen's University Belfast
2018-2025
China Medical University
2017-2025
JSS Academy of Higher Education and Research
2021-2024
Pharmaceutical Biotechnology (Czechia)
2021
AIMST University
2013-2017
Manipal Academy of Higher Education
2012-2013
Oxidative stress is crucial in diabetic pathophysiology, hence the prerequisite of ingesting naturally derived antioxidants as a remedial target. This study investigates occurring antioxidant and antidiabetic potential Moringa oleifera ethanolic leaves extract.Moringa were macerated (MOLE) by using 70% ethanol. Physiochemical phytochemical examinations MOLE was assayed standard methods. The activity analyzed DPPH (1, 1-diphenyl-2-picrylhydrazil) radical scavenging assay. In vitro pancreatic...
The aim of the present study is to analyze viability anti-EGFR anchored immunonanoparticle (INP) bearing Paclitaxel (PTX) specifically bind EGFR protein on TNBC cells. NP was prepared by nanoprecipitation and characterized particle size, charge, entrapment drug release it. integrity confirmed SDS-PAGE. Cytotoxicity NPs cellular uptake analyzed with MDA-MB-468 type cancer cells expression PCR, qualitatively quantitatively. in-vivo antitumor activity INP determined using athymic mice model...
Parkinson's disease (PD) is a neurodegenerative disorder defined by progressive deterioration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Dental pulp stem cells (DPSCs) have been proposed to replace degenerated due its inherent neurogenic and regenerative potential. However, effective delivery homing DPSCs within lesioned brain has one many obstacles faced cell-based therapy disorders. We hypothesized that DPSCs, delivered intranasally, could circumvent these...
Overexpression of anti-apoptotic Bcl-2 is often observed in a wide variety human cancers. It prevents the induction apoptosis neoplastic cells and contributes to resistance chemotherapy. RNA interference has emerged as an efficient selective technique for gene silencing. The potential use small interfering (siRNA) therapeutic agent treatment cancer elicited great deal interest. However, insufficient cellular uptake poor stability have limited its applications. purpose this study was prepare...
Background: Diabetic wound (DW) is the most devastating complication resulting in significant mortality and morbidity diabetic patients. The objective of current study was to formulate Epidermal Growth Factor loaded Chitosan nanoparticle impregnated with thermos-responsive injectable hydrogel protease inhibitor. EGF, shown all stages healing from inflammation proliferation remodelling, combined Doxycycline, a well-known anti-inflammatory anti-bacterial drug, could be better strategy healing....
Jagani, Hitesh Vitthalbhai; Josyula, Venkata Rao; Hariharapura, Raghu Chandrashekar; Palanimuthu, Vasanth Raj; Gang, Sagar Shanti Mal
Background: Triple-Negative Breast Cancer is an aggressive type of breast cancer, which not treatable by chemotherapy drugs, due to the lack Estrogen Receptor (ER), Progesterone (PR) expression and Human Epidermal Growth Factor 2 (HER2) on cell surface. Objective: The aim this study was compare effect paclitaxel loaded PLGA nanoparticle (PTX-NPs) cytotoxicity apoptosis different MDA-MB lines. Method: PTX-NPs were prepared nanoprecipitation method characterized earlier. evaluated MTT LDH...
Several anticancer drugs are getting resisted by the cancer cell and treatment like chemotherapy, radiation causes serious side effects. In immunomodulatory efficiency is less CAR-T cells, CAR-NK cells require enormous time to get adopt in vitro may cause seizures, dilemma, concussion prolonged use against cancer. Even production of NK tedious process. To overcome this situation, peptides can be used, as they don’t have any drug resistance highly potent, with good penetration. The advantages...
The aim of the study was to green synthesis and evaluate antiepileptic activity herbal nanoparticles <i>Mimusops elengi</i> (ME) on electrochemical convulsion models in mice. ME (MEHNPs) were synthesized characterized. particles size zeta potential MEHNPs found be 24 nm 29.5 mV respectively. FTIR revealed that minor shifts peaks may due capping, reduction stabilization MEHNPs. Electro convulsions (ECs) induced using electro-convulsiometer ear-clip electrodes with alternating current 45 mA...
Abstract: Background: Endophytes, markedly receiving interest and has been detected to be remarkable sources of bioactive metabolites. which are also called as endosymbionts have pulled into consideration in the discovery for novel compounds that can utilized new medications. In current study, endophyte isolated from Durio zibethinus leaves. 16s rRNA partial genome sequencing was used identify selected obtained bacterial endophytic crude extract (DZLM) subjected antioxidant antidiabetic...
Neurodegenerative diseases, including Alzheimer's, Huntington's, Parkinson&rsquo;s, and Amyotrophic Lateral Sclerosis, involve neuron degeneration linked to the misfolding of amyloidogenic proteins, resulting in &beta;-sheet-enriched aggregates. This phenomenon disrupts normal folding proteins critical for cellular function. Genetic mutations, proteolytic cleavage, oxidative stress, aging contribute misfolding. Parkinson's disease (PD) is closely tied alpha-synuclein (&alpha;S)...
This study aims to investigate the modulation of ER-β by phytoestrogens (isoflavones) in target diabetic wound healing using computational tools and vitro studies. One primary limitations associated with delayed is inhibiting antioxidant pathways mediated estrogen receptor-β (ER-β). In this study, we screened 50 isoflavones against active pocket (5TOA.pdb). Through XP docking score, evaluated binding pattern dynamic changes top 5 having highest scores, energy, interactions ER-β. Further,...
Butter is one of the widely used fats present in diet. However, there no satisfactory study available that evaluates effect a high-fat diet containing butter as principal fat on development non-alcoholic fatty liver disease (NAFLD).In study, was for steatosis Chang cells an vitro and Swiss albino mice vivo study. In established, compared with oleic acid using oil red O (ORO)-based colorimetric assay. butter-rich special fed 15 weeks to mice, who showed significant change body weight. The...
Biofilms are organized communities of micro-organisms buried firmly on an extra polymeric matrix attached to the living surface. The which is formed surrounding bacteria makes them tolerant harsh environmental conditions as well resistant antibacterial treatment. development biofilms in clinical or hospital settings major reason for several infections. They have a negative impact when they medical devices it difficult eradicate using disinfectants antibiotics available. Several vitro models...
Genetic polymorphism is defined as the presence of a heterozygous deoxyribose nucleic acid (DNA) variant in greater than 1% population. integrates genetic information clinical decision-making. High organic cation transporters (OCT) transport genes may represent significant portion variation pharmacokinetics and pharmacodynamics substrate drugs transported by OCT1. The scarcity research difference effect variability rs628031 various groups provide compelling reasons to perform study. purpose...