A5072515512- Wound Healing and Treatments
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Lipid Membrane Structure and Behavior
- Drug Solubulity and Delivery Systems
- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- RNA Interference and Gene Delivery
- Computational Drug Discovery Methods
- Diabetic Foot Ulcer Assessment and Management
- Periodontal Regeneration and Treatments
- Pharmaceutical studies and practices
- Alzheimer's disease research and treatments
- Bee Products Chemical Analysis
- Silk-based biomaterials and applications
- Curcumin's Biomedical Applications
- Cancer Research and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Antimicrobial Peptides and Activities
- Dermatology and Skin Diseases
- Hydrogels: synthesis, properties, applications
- Protease and Inhibitor Mechanisms
- Pesticide Residue Analysis and Safety
JSS Academy of Higher Education and Research
2016-2025
Kansas City University
2025
Pharmaceutical Biotechnology (Czechia)
2024
GSL Medical College & General Hospital
2020
St George's Hospital
2008
Many of the therapeutics used for treatment brain disorders are not effective and delivered to due complex structure its barriers. In recent years, many advanced approaches have emerged drug delivery. Intranasal delivery is one non-invasive approach has gained interest because direct transport drugs circumventing barriers through olfactory trigeminal nerve pathways. Eventhough these pathways access brain, main limitations this only limited absorption, nasal permeability. To overcome issues...
Breast cancer is the second leading cancer-related disease as most common non-cutaneous malignancy among women. Curative options for breast are limited, therapeutically substantial and associated with toxicities. Emerging nanotechnologies exhibited possibility to treat or target cancer. Among nanoparticles, various lipid nanoparticles namely, liposomes, solid nanostructured carriers polymer hybrid have been developed over years therapy evidences documented. Concepts confined in lab scale,...
Pancreatic cancer poses a significant challenge within the field of oncology due to its aggressive behaviour, limited treatment choices, and unfavourable outlook. With mere 10% survival rate at 5-year mark, finding effective interventions becomes even more pressing. The intricate relationship between desmoplasia hypoxia in tumor microenvironment further complicates matters by promoting resistance chemotherapy impeding efficacy. dense extracellular matrix cancer-associated fibroblasts...
Drug delivery to the brain is challenging because of low permeability blood-brain barrier, and therefore, optimum concentration chemotherapeutics in target area specifically for glioblastoma, an aggressive tumor, opens a new path research. To achieve goal, oral alkylating agent temozolomide was incorporated into niosomes, surface modified with chlorotoxin, small 36 amino acid peptide discovered from venom scorpion
Diabetic wound (DW) is the most devastating complication resulting in significant mortality and morbidity diabetic patients. The standard treatment of DW care fails to address prerequisites treating owing its multifactorial pathophysiology. Henceforth, developing a single strategy handle all loopholes may effectively manage DW. objective current study was formulate Human beta defensin-2 (HBD-2) loaded Poly (lactic-co-glycolic acid) (PLGA) nanoparticle impregnated collagen/chitosan (COL-CS)...
Abstract: Deoxyribonucleic acid (DNA) is the crucial molecule that stores and transmits genetic information in living organisms. DNA can incur damage from various sources, ne-cessitating efficient repair mechanisms to maintain genomic stability. Cells employ multiple pathways, including single-strand double-strand break repair, each involving specific proteins enzymes. PARPs play a fundamental role of detect facilitate process. PARPi are drugs inhib-it PARP activity, leading accumulation...
Diabetic wound is a major problem that often needs amputation of the concerned organ in patients suffering from diabetes. In diabetes, prolonged phase inflammation obstructs further phases healing which, turn, lead to improper wounds Pioglitazone (Pio) hydrochloride an antidiabetic drug with reported anti-inflammatory properties. The aim this study was develop Pio-nanostructured lipid carrier (Pio-NLC)-loaded collagen/chitosan (COL-CS) scaffold and evaluate its ability diabetic wounds....
Nelfinavir mesylate (NFV) is an anti-viral drug, used in the treatment of Acquired Immunodeficiency Syndrome (AIDS). Poor oral bioavailability and shorter half-life (3.5-5 h) remain a major clinical limitation NFV leading to unpredictable drug frequent dosing. In this context, objective present study was formulate loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs), which can increase solubility along with sustained release drug. PLGA-NPs were prepared by nanoprecipitation...
: On the row of various cancers in world, Lung cancer falls to number two both female and male. Various surgical non-surgical therapeutic approaches including chemotherapy, photodynamic therapy, radiotherapy are employed treatment lung cancer. However, most these techniques costly, complex lacks patient compliance. In case it is associated with lack specific tumour targeting, limited drug solubility leads insufficient amount reaches a tumor site. To overcome demerits types nanoparticles...
The current work was carried out by the principles of quality-by-design approach to develop an optimized solid lipid nanoparticles (SLNs) formulation diallyl disulfide (DADS) through systematic statistical study. And its antitumor activity DADS also evaluated on breast cancer cell lines. To understand effect variables (critical parameters) responses quality attributes) SLN, a 3-factor, 3-level Box-Behnken design, explored predict such as particle size (Y1) and % entrapment efficiency (EE)...
Abstract This study aims to develop, characterize, and evaluate the best statin‐loaded Collagen Silver nanoparticle‐coated polycaprolactone nanofibers by electrospinning technique. The characterization evaluation results reveal that had shown an aligned distribution of fibers aliment collagen silver nanoparticle coating material on surface nanofibers. Furthermore, electrospun have no interaction between drug PCL polymeric demonstrated controlled release for 360 h significant degradation 60...
Chloroquine was once the most widely used antimalarial for nearly eight decades its safety, efficiency, stability, low cost and finally less toxic nature. But use efficacy got slowly decreased with increase of chloroquine resistant strains Plasmodium species throughout world. Lipid based nanodrug delivery systems have been very popular in recent times as they are toxic, drug targeting capabilities also reduces dosing frequency by increasing drug. In present research work, response surface...