A5015514216- Synthesis and biological activity
- Computational Drug Discovery Methods
- Cancer therapeutics and mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- PARP inhibition in cancer therapy
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Bioactive Compounds and Antitumor Agents
- Diverse Scientific Research Studies
- SARS-CoV-2 and COVID-19 Research
- Analytical Methods in Pharmaceuticals
- Essential Oils and Antimicrobial Activity
- Antibiotics Pharmacokinetics and Efficacy
- Synthesis of β-Lactam Compounds
- Natural Antidiabetic Agents Studies
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Click Chemistry and Applications
- Synthesis and Reactions of Organic Compounds
- Estrogen and related hormone effects
- Piperaceae Chemical and Biological Studies
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactive Compounds
- Advanced Chemical Sensor Technologies
- Advances in Cucurbitaceae Research
JSS Academy of Higher Education and Research
2015-2025
Pharmaceutical Biotechnology (Czechia)
2024
Nilai University
2013-2021
Deccan School of Hospital Management
2021
KPJ Healthcare University
2013-2020
Anand Agricultural University
2016
La Trobe University
2012
In early 2020, many scientists are rushing to discover novel drugs and vaccines against the coronavirus, treatments for COVID-19, because coronavirus disease 2019 (COVID-19), a life-threatening viral disease, affected first in China quickly spread throughout world. this article, silico studies have been performed explore binding modes of chemical constituents natural remedies like Curcuma longa (turmeric) Andrographis paniculata COVID-19 (PDB ID 5R82) targeting using Schrodinger suit 2019-4....
BACKGROUND: In early 2020, many scientists are rushing to discover novel drugs and vaccines against the coronavirus, treatments for coronavirus disease 2019 (COVID-19), because, which was named as COVID-19, a life-threatening viral affected first in china quickly spread throughout world.OBJECTIVE: present article, silico studies have been performed explore binding modes of chemical constituents natural remedies such pepper, ginger, garlic COVID-19 (PDB id-5R82) targeting using Schrodinger...
Human Epidermal development factor Receptor-2 (HER2) is a membrane tyrosine kinase which overexpressed and gene amplified in human breast cancers. HER2 amplification overexpression have been linked to important tumor cell proliferation survival pathways for 20% of instances cancer. 9-aminoacridines are significant DNA-intercalating agents because their antiproliferative properties.Some novel isoxazole substituted 9-anilinoacridines(1a-z) were designed by in-silico technique inhibitory...
Coronavirus disease (COVID-19), a life-threatening disease, is caused by SARS-CoV-2. The targeted therapeutics of small molecules helps the scientific community to fight against In this article, some oxazine substituted 9-anilinoacridines (A1-A48) was designed docking, MM-GBSA and molecular dynamics (MD) simulation studies for their COVID-19 inhibitory activity. docking ligands A1-A48 SARS-CoV-2 (PDB ID: 5R82) are performed using Glide module, in silico ADMET screening QikProp binding energy...
Cancer is a condition marked by abnormal cell proliferation that has the potential to invade or indicate other health issues. Human beings are affected more than 100 different types of cancer. Some cancer promotes rapid proliferation, whereas others cause cells divide and develop slowly. cancers, such as leukemia, produce visible tumors, while others, breast cancer, do not. In this work, in silico investigations were carried out investigate binding mechanisms four major analogs, which marine...
The antidiarrhoeal effect of the water extract Melastoma malabathricum Linn. (Melastomataceae) leaves were investigated by employing four experimental models diarrhea in Swiss mice. treated mice showed significant reduction fecal output and protected them from castor oil-induced diarrhoea. also reduced intestinal fluid secretion induced magnesium sulphate gastrointestinal motility after charcoal meal administration No mortality visible signs general weakness was observed following test up to...
Abstract: Introduction: In general, 9-aminoacridine derivatives are inhibiting DNA topoisomerase II (topoII) because of their strong activity due to the ability acridine nucleus intercalate into base pair. To get insight intermolecular interactions, molecular docking studies performed at active site II. Aim: this study, an attempt is made for identification potential ligands from oxazine substituted 9-anilino acridines targeted against topoisomerase-II (1ZXM) using modelling and by...
A convenient synthesis of novel isoxazole-substituted 9-anilinoacridine derivatives 5a–j was reported. The compounds were confirmed by physical and analytical data screened for in vitro antioxidant activity DPPH method, reducing power assay total capacity method. cytotoxic the also studied HEp-2 cell line. docking studies synthesized performed towards key nucleoside dsDNA using AutoDock vina 4.0 programme. All have significant activities.
Cancer manifests as uncontrolled cell proliferation. Tankyrase, a poly(ADP-ribose) polymerase member, is vital in Wnt signal transmission, making it promising cancer therapy target. The Wnt/β-catenin pathway regulates critical biological processes like genomic stability, gene expression, energy utilization, and apoptosis. Its dysregulation contributes to development. Targeting tankyrase within this holds the potential for inhibiting aberrant growth promoting programmed death, offering avenue...
Abstract: Deoxyribonucleic acid (DNA) is the crucial molecule that stores and transmits genetic information in living organisms. DNA can incur damage from various sources, ne-cessitating efficient repair mechanisms to maintain genomic stability. Cells employ multiple pathways, including single-strand double-strand break repair, each involving specific proteins enzymes. PARPs play a fundamental role of detect facilitate process. PARPi are drugs inhib-it PARP activity, leading accumulation...
This article focuses on the synthesis of new series pyrazole‐substituted 9‐anilinoacridine derivatives 5a – m and 6a l . The compounds were confirmed by physical analytical data. synthesized when screened for in vitro antioxidant activity showed promising many compounds. selected cytotoxic inhibition HEp‐2 cell line 6c , 6e 6f