A5055760084- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Computational Drug Discovery Methods
- Vagus Nerve Stimulation Research
- Wnt/β-catenin signaling in development and cancer
- Estrogen and related hormone effects
- Cancer, Stress, Anesthesia, and Immune Response
- Medicinal Plants and Neuroprotection
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Histone Deacetylase Inhibitors Research
- Mosquito-borne diseases and control
- Protease and Inhibitor Mechanisms
- Biochemical Analysis and Sensing Techniques
- Cannabis and Cannabinoid Research
- Sleep and Wakefulness Research
- Phytochemicals and Medicinal Plants
- Nanoparticle-Based Drug Delivery
- Nuclear Receptors and Signaling
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Pain Management and Treatment
- Advanced Drug Delivery Systems
- Adenosine and Purinergic Signaling
- S100 Proteins and Annexins
Vignan's Foundation for Science, Technology & Research
2025
JSS Academy of Higher Education and Research
2021-2024
Triple-negative breast cancer (TNBC) lacks the expression of oestrogen receptor (ER), progesterone (PR), and human epidermal growth factor 2 (HER2), rendering it unresponsive to endocrine therapy HER2 targeted treatments. Though certain chemotherapeutics targeting cell cycle have shown efficacy a extent, presence chemotherapy-resistant stem cells (CSCs) presents significant challenge in tackling TNBC. Multiple lines evidence suggest upregulation neuropeptide Substance P (SP), its NK-1 (NK1R)...
ABSTRACT A novel ultraperformance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometric (UPLC‐Q‐ToF/MS) method for quantifying soy‐derived bioactive peptide lunasin in rabbit plasma was developed using design of experiments (DoE) methodology. Lunasin and Neuropeptide Y as an internal standard (IS) were separated on a BEH‐C18 column (50 mm × 2.1 mm, 1.7 μm particle size) 0.1% formic acid solution acetonitrile mobile phase delivered 9 min at constant flow rate 0.4...
Background: Diabetic wound (DW) is the most devastating complication resulting in significant mortality and morbidity diabetic patients. The objective of current study was to formulate Epidermal Growth Factor loaded Chitosan nanoparticle impregnated with thermos-responsive injectable hydrogel protease inhibitor. EGF, shown all stages healing from inflammation proliferation remodelling, combined Doxycycline, a well-known anti-inflammatory anti-bacterial drug, could be better strategy healing....
Abstract Alzheimer’s disease (AD) has no Food and Drug Administration (FDA) approved drugs that can halt neurodegeneration. To neurodegeneration, targeting the major pathways underlying in AD might be potential strategy. One such are Amyloid-β (Aβ) tau which majorly regulated by β- amyloid precursor protein cleaving enzyme 1 (BACE1) Glycogen synthase kinase (GSK-3β) respectively. BACE1 is a crucial involved Aβ formation & generation GSK-3β one of kinases responsible for...
Alzheimer's disease (AD) is one of the most concerned neurodegenerative disorders across world characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFTs), leading to cognitive decline memory loss. Targeting key pathways involved in AD like Aβ NFT pathways, are crucial for development effective therapeutic strategies. In this study, we aimed identify establish promising dual inhibitors targeting BACE1 GSK-3β, two proteins implicated formation respectively.